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- Newsgroups: sci.bio
- Path: sparky!uunet!noc.near.net!mv!world!eb3
- From: eb3@world.std.com (Edwin Barkdoll)
- Subject: Re: MRNA
- Message-ID: <C17DA4.FwJ@world.std.com>
- Organization: The World Public Access UNIX, Brookline, MA
- References: <105875@netnews.upenn.edu> <1993Jan21.041055.24779@organpipe.uug.arizona.edu>
- Date: Thu, 21 Jan 1993 11:58:52 GMT
- Lines: 46
-
- In article <1993Jan21.041055.24779@organpipe.uug.arizona.edu> sfm@manduca.neurobio.arizona.edu (Stephen Matheson) writes:
- >From article <105875@netnews.upenn.edu>,
- >by barkdoll@lepomis.psych.upenn.edu (spacesareforthefeebleminded):
- >> In article <1759@tdat.teradata.COM> swf@tools3teradata.com
- >> (Stan Friesen) writes:
- >>>In article <104941@netnews.upenn.edu>,
- >>>rowe@pender.ee.upenn.edu (Mickey Rowe) writes:
- >
- >>>|> >The brain statement is based on the fact that neurons have less
- >>>|> >DNA per unit weight than other kinds of cells (eggs-cluding eggs
- >>>|> >and who knows what other special cases).
- >
- >>>|> I suspect that this is generally untrue.
- >
- >>>Ah, but it is in fact exactly literally true! All cells in a single
- >>>body have the *same* amount of DNA (with a few wierd exception like
- >>>the polytene chromosomes in the salivary glands of Drosophila).
- >
- >> Ah, but it is in fact exactly literally false! Class
- >> switching of B cells, antigen specificity selection of immunoglobulins
- >> and T cell receptor specifity all involve deletion and recombination
- >> of DNA. Then of course most ("most" is just to hedge my bets) mature
- >> mammalian red blood cells have NO nuclear DNA.
- >
- >First of all, I would argue that both your examples might be classified
- >as "weird exceptions".
-
- Given that the number of neurons claimed to be in the human
- brain is ~10^11 and the number of RBC's in the average male is about
- 10^13, together with the fact that marsupials, monotremes and
- eutherian mammals have anucleate RBC's, I suggest that you have an odd
- sense of what is a "weird exceptino". Ditto for B and T cells.
- Although the numbers in a normal individual are lower - say a
- mere 10^10 - they are ubiquitous in mammals, birds and possibly
- reptiles, amphibians and fish (not sure about the last three).
-
- >More importantly, I am skeptical that the
- >DNA rearrangements you refer to could have any measureable effect on
- >the rather crude DNA-per-unit-weight measurement.
-
- Obviously. That was not my point regarding B and T cells,
- rather I took exception to Stanley's strong statement above.
-
- --
- Edwin Barkdoll
- eb3@world.std.com
-