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- From: Billi Goldberg <bigoldberg@igc.apc.org>
- Subject: Estrogen Article in SF Sentinel
- Message-ID: <1992Dec24.145929.9198@cs.ucla.edu>
- Note: Copyright 1992, Dan R. Greening. Non-commercial reproduction allowed.
- Sender: usenet@cs.ucla.edu (Mr Usenet)
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- Archive-Number: 6673
- Organization: unspecified
- Date: Wed, 23 Dec 92 20:40:02 PST
- Approved: phil@wubios.wustl.edu (J. Philip Miller)
- Lines: 40
-
- The following article was printed in the San Francisco Sentinel on
- Thursday, December 24, 1992. It is being posted with the permission of
- the author, Charles R. Caulfield.
- ************************************************************************
- Female Hormones Show Immune Modulation
- by Charles R. Caulfield
-
- Some interesting new data documented in the medical literature has
- demonstrated that taking the female hormone estrogen may in some way
- stimulate the immune system, and have some activity against HIV in the
- body.
-
- According to the Encyclopedia of Immunology, Academic Press, 1992,
- estrogen exhibits a profound effect on the macrophage, an important
- immunological white blood cell, in laboratory animals. According to the
- text, "Estrogen treatment of male rats increases macrophage
- numbers...and modulate macrophage activity." It goes on to state that
- "Macrophages from estrogen treated animals show increased lysis
- (destruction) of tumors, and inhibit the growth of tumor cells.
- Estrogens stimulate the production of IL-1 by macrophages." IL-1 or
- Interleukin 1 is an immunologic protein produced by macrophages which
- signals the proliferation of T-lymphocytes.
-
- Three recently published papers in the medical literature have
- described the activity in humans of estrogen against HIV in certain
- blood cells. The results reported in the abstract of one of the articles
- suggests that in vivo low doses of female steroids may display specific
- antiviral activity in peripheral blood mononuclear cells.
-
- Another published article has reported that the female hormone
- estradiol demonstrated an inhibitory effect against the
- immunosuppressive effects of cyclosporine A, an anti-inflammatory
- steroid known to profoundly suppress the immune system, demonstrating an
- immunostimulant effect of this female hormone.
-
- Although this data has received little mention in the popular press, it
- may hold out profound significance for the treatment of HIV disease.
- Certainly, the demonstrated antiviral and immune modulating properties
- of these hormones warrants further investigation in the search for
- effective AIDS treatments.
-