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- From: lamontg@stein.u.washington.edu (Lamont Granquist)
- Subject: Re: post-Prozac reactions
- Message-ID: <1992Dec21.150104.2296@u.washington.edu>
- Sender: news@u.washington.edu (USENET News System)
- Organization: 'Operation: Mindcrime'
- References: <1992Dec14.133117.20486@u.washington.edu> <1992Dec15.172745.27468@newstand.syr.edu> <1go0liINNt66@agate.berkeley.edu> <1992Dec20.133028.10836@newstand.syr.edu>
- Date: Mon, 21 Dec 1992 15:01:04 GMT
- Lines: 56
-
- mdkline@rodan.acs.syr.edu (Mark D. Kline) writes:
- >Results of large scale reviews - involving thousands of cases - suggests
- >that the risk of suicidal or violent behavior is not different between
- >patients taking Prozac and patients taking other antidepressant medications.
-
- You see this isn't sufficient, however, to rule out a small population of
- patients that have an honest-to-god biochemical reaction to Prozac which
- causes either suicidal ideation or fits of rage. What it *does* mean is
- that Prozac is a relatively quite safe anti-depressant. However, I got
- effects off of Prozac which felt quite out-of-character, quite "detatched"
- from my psychology, and felt like a drug reaction.
-
- The thing is that I seem to have a hellishly screwed up biochemistry when
- it comes to these drugs. After three days on desipramine, I started to
- develop something which looked like it was progressing into amphetamine
- psychosis (I was definitely paranoid -- the faint mumbling voices were
- getting a little louder each day...). Nortryptyline and Wellbutrin just
- had sedation and no were no particular help. Prozac had the weirdness that
- I posted about. And phenelzine at 75mg/day 5 times/day knocked me into a
- really, really, really bad bout of depressive ideation -- I kept on having
- depressed thoughts feel like they zipped around my head, built up momentum
- and slammed into me... completely incapacitating and about an order of
- magnitude worse than any dysphoric mood I ever encountered before (since I
- normally don't have that bad of a problem with a dysphoric mood). 45mg of
- phenelzine later I was asleep and the next day was completely sane -- other
- than being in a bit of shock and scared shitless... switched doses from
- 15mg x 5times/day to 75mg once/day and that problem has never come back...
-
- Someone out there is probably now sloughing this off as "pffft... its all
- in his head...". All, I can say, is you should really fuck around with
- these drugs as much as I have... eventually, I'll bet you'll find a magic
- combination that gives you some really unusual psychiatric side effects...
-
- However, I seem to have some exceptionally weird-ass side effects. But,
- since a person can't predict in advance if they will have typical or atypical
- reactions to a drug, they should just be a little cautious and take note of
- their mental state while on the drug.
-
- And, the only other thing that bugs me is doctors who seem to have an amazing
- amount of skepticism for biochemically produced phenominon. If a patient
- is genuinely experiencing a biochemical reaction of rage, depression, etc,
- they well probably be told that "its just a normal symptom of depression and
- not the drug." How can the doctor actually tell though? what questions can
- be asked to tell the difference between a biochemical state due to a drug and
- a nearly identical psychological state? It seems like they're assuming a
- psychological cause even though they know damn well that the patient has
- a poorly-understood psychotropic drug in their system... Strange, because its
- like the opposite of the "blame the drug" phenominon WRT illegal drugs -- in
- this case its the "blame the patient" phenominon... It'd be nice to get a
- little recognition that those studies cannot rule out possibilities of
- unusual side effects in a small percentage of patients...
-
- --
- Lamont Granquist lamontg@u.washington.edu
- "When dogma enters the brain, all intellectual activity ceases."
- -- Robert Anton Wilson
-