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- Xref: sparky sci.med:21220 alt.support.diet:2833
- Newsgroups: sci.med,alt.support.diet
- Path: sparky!uunet!think.com!spdcc!dyer
- From: dyer@spdcc.com (Steve Dyer)
- Subject: Re: lipase inhibitors
- Message-ID: <1992Nov19.054406.11322@spdcc.com>
- Organization: S.P. Dyer Computer Consulting, Cambridge MA
- References: <1992Nov17.193224.15949@spdcc.com> <Bxxq2H.8HK@dale.cts.com>
- Date: Thu, 19 Nov 1992 05:44:06 GMT
- Lines: 29
-
- In article <Bxxq2H.8HK@dale.cts.com> npm@dale.cts.com (Nancy Milligan) writes:
- >Hey, this is cool! Fat inhibitors... I like that. Now if only there
- >were a pill, maybe there is, that'd turn off the juices secreted by
- >my thighs and rear that says "deposit all fat here".
-
- Well, fat distribution is under hormonal control, and the particular
- fat distribution most women have (on the hips, rear and thighs,
- classically described as "gynoid") is facilitated in large part by
- estrogen. Of course, compounds with some degree of activity as
- anti-estrogens are available (Tamoxifen, Clomid), but I think
- taking something like this that would be a little extreme, given
- that this is only "abnormal" culturally. I also don't know whether
- such drugs would have any effect on fat distribution, for a number
- of reasons.
-
- There was a study done by George Bray at UCLA, a well-known obesity
- researcher, which looked at the effect of topical creams containing a
- mixture of adrenergic agents (essentially adrenalin-analogues and
- theophylline, a caffeine-like substance) on local fat distribution.
- Believe it or not, the cream appeared to work! Women who were their
- own controls showed reductions in circumference on the treated thigh
- compared to the untreated thighs. But I've never seen any followup on
- this work. I don't know if it turned out that the study was bogus,
- couldn't be replicated, or whether this was just too wacky or National-
- Enquirer-like an idea to pursue any further.
-
- --
- Steve Dyer
- dyer@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer
-