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- Path: sparky!uunet!zaphod.mps.ohio-state.edu!usc!usc!not-for-mail
- From: jdevlin@pollux.usc.edu (Joseph T. Devlin)
- Newsgroups: bionet.neuroscience
- Subject: Alzheimer's disease
- Date: 22 Nov 1992 14:18:53 -0800
- Organization: University of Southern California, Los Angeles, CA
- Lines: 28
- Distribution: world
- Message-ID: <1ep10eINNlaf@pollux.usc.edu>
- NNTP-Posting-Host: pollux.usc.edu
- Summary: Effect of neurofibrillary tangles and amyloid plaque
-
- In Alzheimer's disease two of the neuropathological conditions
- mentioned most frquently are the presence of neurofibrillary
- tangles and overproduction of beta-amyloid leading to plaque
- formation. As often as I see this information, however, I never
- have seen any suggestions as to how these affect the normal
- processing characteristics of a neuron. Presumably since both
- are pathological they have some affects which might very well differ
- between cell types or even among cell types but I haven't come
- across this information if that is so.
- For tangles I would assume this might affect process lengths
- if only because they damage cytoskeletal elements. I have
- no idea what effect plaques might have.
- Can anyone answer any of these questions or perhaps point me
- towards appropriate references? In the event these are still
- unanswered questions would anyone care to speculate on the
- effects?
- Thank you all in advance.
-
- - Joe
-
- *************************************************************************
- Joseph Devlin * email: jdevlin@pollux.usc.edu
- University of Southern California *
- Department of Computer Science * "The axon doesn't think.
- Los Angeles, CA 90089 * It just ax." George Bishop
- *************************************************************************
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