If you hold Shift while inserting a linebreak (either from the toolbar or with the Crtl+Enter shortcut), the tag will be added to the end of the current line. This works with multiple lines selected as well.
The Bold and Italics buttons work with any currently selected text. For example, you can highlight a few words, then click the Bold button to place the tags around them.
You can easily comment out sections of HTML with the Comment button. Any text which is selected when you click comment will be commented out. Likewise, by highlighting a comment and clicking the button, the text will be un-commented.
If you highlight some text, then click the Insert Link button, the selected text will be copied into the Text field of the Insert Link window. Now simply type the URL and click Insert to make a link out of the text that was selected.
When adding tags from the Insert Table window, you don't need to click where the tag needs to be inserted each time. For example, after inserting <table> you don't need to click between the "e" and the ">" and add a space before clicking the button to insert the "width" paramater. The program will automatically do this for you. At this point you could then type in the width's value and click the "height" button, without having to move the entry point.
You can use "../" in a path (to an image, webpage,etc.) to reference the parent directory of the current file. For example, <img src="../header.gif">
The default font when the program is installed is Courier New, because it is a fixed-width font, meaning each character is the same width. Fixed-width fonts make reading HTML easier (in my opinion). Other fixed-width fonts include Terminal and Fixedsys.