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- Path: sparky!uunet!cs.utexas.edu!asuvax!ncar!noao!amethyst!organpipe.uug.arizona.edu!news
- From: sfm@manduca.neurobio.arizona.edu (Stephen Matheson)
- Newsgroups: talk.abortion
- Subject: Re: Spoken Like a True ProLifer
- Message-ID: <1993Jan22.012528.8372@organpipe.uug.arizona.edu>
- Date: 22 Jan 93 01:25:28 GMT
- References: <JBATES.93Jan21025010@pinocchio.encore.com>
- Sender: news@organpipe.uug.arizona.edu
- Organization: University of Arizona UNIX Users Group
- Lines: 51
-
- From article <JBATES.93Jan21025010@pinocchio.encore.com>,
- by jbates@encore.com (John W. Bates):
-
- [Deleted discussion in which John and I finally agree that demyelination
- leads to conduction block and renders comparison with unmyelinated
- fetal fibers nearly useless.]
-
- > Here's another question: do the internodal regions develop before or
- > after myelination occurs? If before, then one *can* compare demyelinated
- > humans to unmyelinated fetuses, at least on an axon to axon level.
-
- If I understand your first question, the answer is yes, I believe
- that most fibers are excitable *before* myelination due to the
- presence of sodium channels in the internodal membrane. After
- myelination, the sodium channels become concentrated at the
- nodes and may be completely absent in between. Since the sodium
- channels redistribute themselves after chronic demyelination
- (I don't know the time course), then you're right: one could
- compare chronically demyelinated fibers to unmyelinated ones, on
- an axon by axon basis. Unfortunately, it is quite difficult to
- study vertebrate behavior (much less human cognition) on an
- axon by axon basis.
-
- [Deletia. Multiple sclerosis is a mystery to all of us.]
-
- >>> If my hypothesis is correct (that the cognitive abilities of adult
- >>> humans are dependent upon synchronized activities within the
- >>> brain), then cognition (in the commonly accepted fashion) is
- >>> dependent upon myelin. Testable hypothesis, and I'll try to find
- >>> evidence to back it up. Now, this implies that an unmyelinated
- >>> fetus is either not cognitive, or is cognitive in some radically
- >>> different fashion.
-
- >> Your hypothesis also requires the assumption that myelin is
- >> necessary for synchronized activity.
-
- > That's a very reasonable assumption, if and only if a synchronized
- > activity occurs involving both myelinated and unmyelinated portions.
- > I've been trying to find references to such processes, but I've been
- > unsuccessful thus far. Mostly 'cause I can't get to the library until
- > next week. My own references tend to gloss over descriptions of the
- > physical aspects of any one section of the brain, and describe the
- > serial aspects instead.
-
- Take your time, John. I have a few experiments to do myself, and
- I need a breather. :-)
-
- --
-
- Steve Matheson Program in Neuroscience University of Arizona
- sfm@neurobio.arizona.edu
-