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- Path: sparky!uunet!ogicse!das-news.harvard.edu!husc-news.harvard.edu!husc.harvard.edu!robison1
- From: robison1@husc10.harvard.edu (Keith Robison)
- Newsgroups: sci.bio
- Subject: Re: rRNA (was Re: MRNA)
- Message-ID: <robison1.727971444@husc.harvard.edu>
- Date: 25 Jan 93 14:17:24 GMT
- Article-I.D.: husc.robison1.727971444
- References: <106214@netnews.upenn.edu> <C1CEo4.LuB@iat.holonet.net> <106376@netnews.upenn.edu>
- Lines: 55
- Nntp-Posting-Host: husc10.harvard.edu
-
- rowe@pender.ee.upenn.edu (Mickey Rowe) writes:
-
-
- >Does anybody know if all of these copies are *really* identical?
- >Given that (in my understanding anyways) new genes arise largely from
- >copies of previously existing genes, how is it that the sequences of
- >the copies of the rRNA genes in _X. laevis_ don't mutate
- >independently? (I'm still close to the beginning of Futuyma's book,
- >so please feel free to respond by telling me to keep reading :-)
-
- >Mickey Rowe (rowe@pender.ee.upenn.edu)
-
-
- It's called concerted evolution. Mechanistically, it occurs
- through gene conversion.
-
- Here's how it goes. When chromatids pair during meiosis, recombination
- normally occurs by an _exchange_ of part of the paired region. So,
- if you have:
-
-
- a-b-c-d paired with
- e-f-g-h
-
- you might get something out like:
-
- a-f-g-d and
- e-b-c-h
-
- But sometimes, instead of an exchange the information on one strand
- displaces the information on the other (by mechanism which are still
- under argument, I believe [corrections welcome]). Thus, you
- could end up with:
-
- a-b-c-d and
- e-b-c-h
-
-
- Because rRNA's are generally present as long tandem arrays, they
- have many chances to recombine/convert, because pairing can occur
- between ANY two members of the array. Since this multiplies the
- number of opportunities for conversion, conversion is observed
- at a high frequency and, viola!*, all the rRNA's of a species
- appear to evolve "in concert".
-
-
- Keith Robison
- Harvard University
- Department of Cellular & Developmental Biology
- Department of Genetics / HHMI
-
- robison@biosun.harvard.edu
-
-
- * - pun not originally intended. Too bad!
-