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- Newsgroups: sci.med.aids
- Path: sparky!uunet!usc!ucla-cs!usenet
- From: Billi Goldberg <bigoldberg@igc.apc.org>
- Subject: AZT Resistance
- Message-ID: <1993Jan1.173311.3334@cs.ucla.edu>
- Note: Copyright 1992, Dan R. Greening. Non-commercial reproduction allowed.
- Sender: usenet@cs.ucla.edu (Mr Usenet)
- Nntp-Posting-Host: sole.cs.ucla.edu
- Archive-Number: 6702
- Organization: unspecified
- Date: Fri, 1 Jan 93 09:07:31 PST
- Approved: phil@wubios.wustl.edu (J. Philip Miller)
- Lines: 53
-
- The following has been summarized and excerpted from the San Francisco
- Chronicle, Friday, January 1, 1993.
-
- It makes very interesting reading. I am very curious how the AZT "spin
- doctors" will handle the reality that AZT is not working. Considering
- the number of deaths of people who have used AZT, I have doubts that it
- ever did anything more than suppress the immune system. A new research
- focus at NIH is using AZT as soon as possible after an individual sero-
- converts. Then they checked the lymph nodes to see how effective the AZT
- treatment was. Believe it or not, the AZT treatment was totally
- ineffective. Big surprise!
-
- I wonder what will happen to AIDS research when the money from Burroughs
- Wellcome dries up? Most of the antiviral research and trials in this
- country involves the combination of AZT with everything but the kitchen
- sink. There will be quite a few doctors, scientists, and researchers out
- of work.
-
- ------------------------------------------------------------------------
-
- MORE AIDS PATIENTS SHOW RESISTANCE TO AZT
-
- More AIDS patients are showing early resistance to AZT, the drug most
- commonly used against the disease, and researchers say there is an
- urgent need to develop new drugs to combat the epidemic.
-
- Dr. Wendell T.W. Ching of the School of Medicine at the University of
- California at Los Angeles said blood tests are turning up increasing
- numbers of AIDS-infected patients who have never taken AZT and are sick
- with a virus that is naturally resistant to the drug.
-
- "Some of the patients may have gotten the virus from other patients who
- had been taking AZT and who are now transmitting the resistant virus,"
- Ching said. A report on the blood test study appears today in the
- Proceedings of the National Academy of Sciences.
-
- Ching said earlier studies had attributed AZT resistance to long-term
- use of the drug. The new study shows the resistance may occur naturally
- in patients who have never taken AZT, or that the resistant virus can
- spread from a patient who has taken the drug to one who had been
- disease-free.
-
- AZT is the common name for zidovudine, the first anti-viral drug
- approved for use against the AIDS virus. There now are two other drugs,
- called ddI and ddC, but AZT remains the primary drug.
-
- Resistance to drugs is a common phenomenon in medicine, Ching said.
-
- Researchers said their studies suggest that "with widespread use of
- AZT," the modest beneficial effect of the drug may diminish in time.
-
- "This concern emphasizes the urgent need to quickly develop other anti-
- HIV drugs for clinical use," the study said.
-