home *** CD-ROM | disk | FTP | other *** search
- Newsgroups: sci.med.aids
- Path: sparky!uunet!news.claremont.edu!ucivax!ucla-cs!usenet
- From: Neon@cup.portal.com
- Subject: Re: CMV
- Message-ID: <1992Dec23.131624.26046@cs.ucla.edu>
- Note: Copyright 1992, Dan R. Greening. Non-commercial reproduction allowed.
- Sender: usenet@cs.ucla.edu (Mr Usenet)
- Nntp-Posting-Host: sole.cs.ucla.edu
- Archive-Number: 6669
- Organization: unspecified
- Date: Tue, 22 Dec 92 23:35:13 PST
- Approved: phil@wubios.wustl.edu (J. Philip Miller)
- Lines: 42
-
- In an article 12/20/92 11:12 page@writer.yorku.ca (Page Westcott) writes:
-
- >A friend of mine who has been taking foscarnet for almost a year for
- >CMV Retinitis has recently been asked to take part in a study which
- >involves injecting gancyclovir directly into the eyeball and reducing
- >the amount of foscarnet taken daily. I believe he is taking 350ml of
- >foscarnet daily, 5 days a week and will reduce this frequency to only
- >twice a week.
- >
- >Has anyone heard of this treatment and if so the success rate? His
- >sight has not deteriorated very much in the past 12 months, and it
- >seems to me it would be better to leave well enough alone at this
- >point in his treatment.
- >
- >Thanks, P.
- Well since no one else has taken you up on this, I'll put my 2 cents in.
-
- Standard therapy for CMV retinitis is IV infusions of either foscarnet or
- gancyclovir. 12 months seems like a long time to be on foscarnet or even
- gancylovir, though treatment is lifelong.
-
- Both drugs have serious side effects and the attempt to reduce systemic
- levels of foscarnet while still protecting the retina are probably
- worthwhile. Orthodox treatment of eye infections in HIV negative patients
- sometimes includes injecting antibiotics directly into the eye.
-
- The experimental treatment that I have heard about in reference to CMV
- retinitis involves implanting a capsule into the eye which gradually
- releases gancyclovir into the occular fluid and hopefully would be active
- in preventing or retarding further damage to the retina for weeks or months
- at a time. The standard procedures would require injections frequently and
- would, of course, not be acceptable to most patients as the procedure would
- have to done indefinitely. It might be tolerated in infections affecting
- people with normal immune systems because only a limited number of
- injections would be needed.
-
- PLEASE NOTE: I am neither a doctor nor a medical researcher but simply a
- PWA who has tried to keep up with current medical practice and research as
- best I can. If anyone has more accurate or more detailed information,
- please correct me if I've erred.
-
- Tony Bruder - neon@cup.portal.com
-