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- Newsgroups: sci.med
- Path: sparky!uunet!psinntp!newstand.syr.edu!rodan.acs.syr.edu!mdkline
- From: mdkline@rodan.acs.syr.edu (Mark D. Kline)
- Subject: Re: post-Prozac reactions
- Message-ID: <1992Dec22.173756.28838@newstand.syr.edu>
- Organization: Syracuse University, Syracuse, NY
- References: <1go0liINNt66@agate.berkeley.edu> <1992Dec20.133028.10836@newstand.syr.edu> <1992Dec21.150104.2296@u.washington.edu>
- Date: Tue, 22 Dec 92 17:37:56 EST
- Lines: 34
-
- In article <1992Dec21.150104.2296@u.washington.edu> lamontg@stein.u.washington.edu (Lamont Granquist) writes:
- >mdkline@rodan.acs.syr.edu (Mark D. Kline) writes:
- >>Results of large scale reviews - involving thousands of cases - suggests
- >>that the risk of suicidal or violent behavior is not different between
- >>patients taking Prozac and patients taking other antidepressant medications.
- >
- >You see this isn't sufficient, however, to rule out a small population of
- >patients that have an honest-to-god biochemical reaction to Prozac which
- >causes either suicidal ideation or fits of rage. [ stuff deleted ]
-
- I'll admit that its possible. I haven't seen it in my own experience.
- What is important for people to know is that despite individual experiences
- reported here, Prozac is NOT more likely to induce a paradoxical increase
- in suicidality than other antidepressants. The risk of treatment emergent
- suicidality among patients on antidepressants has been estimated to run as
- high as 3%, which seems a very high estimate (too high) in my experience.
-
- >The thing is that I seem to have a hellishly screwed up biochemistry when
- >it comes to these drugs. After three days on desipramine, I started to
- >develop something which looked like it was progressing into amphetamine
- >psychosis
-
- Such reactions have been reported for desipramine and I've seen
- people get psychotic on tricyclics (I would have predicted such responses
- would be more common with Wellbutrin, but they don't seem to be).
-
- These medications are about quality of life, in my book. If they
- improve the quality of life, raise a person's level of functioning,
- they should be continued. If there is only questionable improvement,
- consideration of a trial of life without medication is definitely
- warranted.
-
-
-
-