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  1. Path: sparky!uunet!psgrain!puddle!f240.n353.z1.fidonet.org!JIM.DIXON
  2. From: JIM.DIXON@f240.n353.z1.fidonet.org (JIM DIXON)
  3. Sender: ufgate@puddle.fidonet.org (newsout1.26)
  4. Newsgroups: k12.ed.science
  5. Subject: TCDD2
  6. Message-ID: <32326.2B37BA9F@puddle.fidonet.org>
  7. Date: Sun, 20 Dec 92 11:56:00 PDT
  8. Organization: FidoNet node 1:353/240 - The Polish Connecti, Westbank BC
  9. Lines: 125
  10.  
  11. Sampling from IRPTC/UNEP using TCDD as search key. (I suggest you set your
  12. margins to 0 and 80.)
  13.                  IDENTIFIERS, PRODUCTION, PROCESSES AND WASTE
  14.                  IDENTIFIERS
  15.  ..................................................................
  16.  ISN=115
  17.  CHEMICAL NAME:  2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN
  18.  COMMON NAME:  TCDD
  19.  RTECS NUMBER: HP3500000 WISWESSER:
  20.  CAS NUMBER: 1746-01-6
  21.  MOLECULAR WEIGHT: 322
  22.  MOLECULAR FORMULA:  C12H4CL4O2
  23.  SYNONYMS: DIBENZO-P-DIOXIN, 2,3,7,8-TETRACHLORO DIOXIN NCI-C03714 TCDBD TCDD
  24.            2,3,7,8-TCDD 2,3,6,7-TETRACHLORODIBENZO-P-DIOXIN (GER)
  25.            2,3,7,8-TETRACHLORODIBENZO-1,4-DIOXIN
  26.  MELTING PT: 305-306C               BOILING PT:
  27.  VP:                                N-OCTOH:AQ:
  28.  AQSOL: 2E-7G/L                          STATE:
  29.  COLOUR: COLOURLESS                      ODOUR:
  30.  SURF TEN:                               TASTE:
  31.  FAT.SOL:
  32.  0.57G/L IN BENZENE; 0.04G/L IN LARD OIL
  33.  PARTICLE:EXTREMELY STABLE EVEN ON HEATING TO 700C
  34. =============================================================================
  35.                        CONCENTRATIONS
  36.                        CONCENTRATION DATABASE
  37. ISN=2001
  38.    RTECS-NO: HP3500000   SUBSTANCE: TCDD
  39. CAS NUMBER: 1746-01-6
  40. ...............TEST DESCRIPTION.........    ............TEST CONDITIONS.......
  41. ORGANISM: FISH                              STUDY TYPE:
  42.           CRUS
  43. LIFESTAGE, AGE:          GEOG. AREA: VNM
  44. SPECIFICATION: RIVER
  45. SEX:
  46. MEDIUM: AQ
  47. SAMPLE SIZE:
  48. TEST-SUB: -
  49. SPECIES-STRAIN-SYSTEM: FISH FROM THE DONG NAI RIVER AND PRAWNS FROM SAIGON RIVER
  50.                        3-4 MONTHS AFTER SPRAYING OF HERBICIDES WAS STOPPED IN
  51.                        VIETNAM
  52. TEST METHOD: GC-MS
  53. COMMENTS:    IN VIETNAM, LEVELS TENDED TO BE HIGHER IN FISH FROM INTERIOR RIVERS
  54.              THAN IN THOSE FROM SEACOAST LOCATIONS. FOR COMPARISON 3NG/KG WAS
  55.              FOUND IN FISH FROM A MARKET IN MASSACHUSETTS, (USA).
  56. EVALUATION APPRAISAL:
  57. UNPUB--EVALUATED....REFERENCE.VOLUME..........PAGE.PAGE.....YEAR.............
  58.          PRIMARY:  EVHPAZ    5                    27       1973
  59.          SECONDARY: IARMB8    15                   56       1977
  60.           PRIM. AUTHOR : BAUGHMAN,R.W. & MESELSON,M.
  61.           SECND. AUTHOR: IARC
  62. ..............................................................................
  63. ORGAN  CONC1      CONC2      UNIT   SPEC       MO1 YR1  MO2 YR2  COMMENTS
  64.        49         49         NG/KG-              0        0    IN PRAWNS
  65.        1020       1020       NG/KG  -              0        0    IN FISH
  66. ============================================================================
  67.                        CARCINOGENICITY
  68.                        CARCINOGENICITY DATABASE
  69. ISN=300
  70.    RTECS-NO: HP3500000   SUBSTANCE:  TCDD
  71.    CAS NUMBER: 1746-01-6
  72. ...............TEST DESCRIPTION.........    ............TEST CONDITIONS.......
  73.    ORGANISM: MOUSE                         STUDY TYPE: LAB
  74.    LIFESTAGE ,AGE:                    PURITY:
  75.    SEX/NUMBER EXPOSED:  F 50/DOSE
  76.                         M 50/DOSE
  77.    CONTROL:  125TOT 125TOT
  78.    EXPOSURE:TYPE: LONG
  79.             PERIOD:   LOW: 104       HIGH: 104        UNIT: WK
  80.             ROUTE:
  81.             DOSE:     LOW:0.01       HIGH:2           UNIT:UG/KG  SPEC:WK
  82.             FREQUENCY:LOW:2          HIGH:2           UNIT:D/WK
  83.    SPECIFICATION:
  84.    SPECIES-STRAIN-SYSTEM:     B6C3F1 MICE
  85.    EXPOSURE COMMENTS: MALES RECEIVED 0.01, 0.05 AND 0.5UG/KG/WK. FEMALES
  86.                       RECEIVED 0.04, 0.2, OR 2UG/KG/WK
  87.    IMPURITIES:
  88.    TEST-CONDITIONS:
  89.    TEST METHOD:  ALL SURVIVING ANIMALS KILLED AT 105-108WK
  90.    COMMENTS:
  91.    EVALUATION APPRAISAL:
  92.    VEHICLE SOLVENT: 9:1 CORN OIL-ACETONE
  93.    TEST SUBST/PARTICLE SIZE:
  94. ...EVALUATED........REFERENCE.VOLUME..........PART.PAGE.....YEAR.............
  95.            PRIMARY: DPNSDO    209                  13       1982
  96.         SECONDARY:
  97.           PRIM. AUTHOR :
  98.           SECND. AUTHOR:
  99. ...............EFFECT........................
  100.    ORGANEFFECT REV    ONSET  SEX-AFFECTED  CONTROL    COMMENTS ON RESULT.
  101.    .....  ...... ...    .....  ............  .......    .....................
  102.    LIVER  CAR                  M   18%       11%        HEPATOCELLULAR
  103.                CARCINOMAS IN MALES AT
  104.                                                         0.01UG/KG.
  105.    LIVER  CAR                  M   16%       11%        HEPATOCELLULAR
  106.                                                         CARCINOMAS IN MALES AT
  107.                                                         0.05UG/KG.
  108.    LIVER  CAR                  M   34%       11%        HEPATOCELLULAR
  109.                                                         CARCINOMAS IN MALES AT
  110.                                                         0.5UG/KG.
  111.    LIVER  CAR                  F   4%        1%         HEPATOCELLULAR
  112.                                                         CARCINOMAS IN FEMALES AT
  113.                                                         0.04 AND 0.2UG/KG.
  114.    LIVER  CAR                  F   13%       1%         HEPATOCELLULAR
  115.                                                         CARCINOMAS IN FEMALES AT
  116.                                                         2UG/KG.
  117.    ENDOC  NEO                  F   6%        0%         THYROID FOLLICULAR-CELL
  118.                                                         ADENOMAS IN FEMALES AT
  119.                                                         0.04UG/KG.
  120.    ENDOC  NEO                  F   11%       0%         THYROID FOLLICULAR-CELL
  121.                                                         ADENOMAS IN FEMALES AT
  122.                                                         2UG/KG.
  123.    LIVER  INFL                                          TOXIC HEPATITIS AT HIGH
  124.                                                         DOSE IN BOTH SEXES
  125. =============================================================================
  126. I hope this gives you an idea of the data available Olivia.  You, or your
  127. classmates should feel free to ask for any data.  If the resulting 'hits'
  128. are too large, I'll send them out as a text file on a 360k IBM compatible
  129. floppy. No charge.
  130. ___ Blue Wave/QWK v2.11
  131.                                                                                                                         
  132.  
  133. --  
  134. uucp: uunet!m2xenix!puddle!353!240!JIM.DIXON
  135. Internet: JIM.DIXON@f240.n353.z1.fidonet.org
  136.