home *** CD-ROM | disk | FTP | other *** search
- Newsgroups: bionet.info-theory
- Path: sparky!uunet!spool.mu.edu!agate!dog.ee.lbl.gov!hellgate.utah.edu!csn!boulder!boulder!eddy
- From: eddy@boulder.Colorado.EDU (Sean Eddy)
- Subject: Re: mRNA baud rate
- Message-ID: <eddy.725706161@beagle>
- Sender: news@colorado.edu (The Daily Planet)
- Nntp-Posting-Host: beagle.colorado.edu
- Organization: University of Colorado, Boulder
- References: <C01wvB.CK5@iat.holonet.net>
- Date: 30 Dec 92 09:02:41 GMT
- Lines: 39
-
- ken@iat.holonet.net (Ken Easlon) writes:
- >I'd like to find out the data transmission rate from the nucleus of a
- >typical eukaryotic cell via mRNA. My best guess at this point is
- >somewhere between 300 and 1200 baud.
- >If anyone has any guesses or information or references regarding the rate
- >of mRNA transcription (per cell), I would be very interested in hearing
- >from you.
-
- Alberts (_Molecular Biology of the Cell_, p. 412) cites 2 x 10^8
- nt/min as the average interphase total transcription rate per
- mammalian cell. 40% of that is tRNA/rRNA transcription; so call it
- 1x10^8 nt/min for precursor mRNA transcription.
-
- Now you need a number for how much precursor is spliced out before
- export from the nucleus; I think a reasonable guess in the human
- might be 95%.
-
- Call each nucleotide 2 bits of information, and you get a "data
- transmission rate" on the order of 200 kilobits/sec -- so it's
- closer to Ethernet than an obsolete modem :)
-
- On the other hand, mRNA export uses 3000-4000 lines (nuclear pore
- complexes) according to Alberts, so the rate per line is indeed pretty
- awful - 40 bps or so. The pores are handling a lot of protein traffic
- too though.
-
- - Sean Eddy
- - MRC Laboratory of Molecular Biology
- - sre@mrc-lmb.cam.ac.uk
- - "I'm not convinced we need bigger supercomputers in computational biology--
- last time I checked, the backs of envelopes weren't getting any
- bigger." - Barry Honig, speaking at a meeting on Grand Challenges
- in Computational Structural Biology
-
-
-
-
-
-
-