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- Newsgroups: sci.med
- Path: sparky!uunet!think.com!spdcc!dyer
- From: dyer@spdcc.com (Steve Dyer)
- Subject: Re: Deprenyl
- Message-ID: <1992Nov21.202529.18906@spdcc.com>
- Organization: S.P. Dyer Computer Consulting, Cambridge MA
- References: <1992Nov16.235730.2369@cnsvax.uwec.edu> <1992Nov17.181034.13282@spdcc.com> <1992Nov20.060539.0430184@locus.com>
- Date: Sat, 21 Nov 1992 20:25:29 GMT
- Lines: 20
-
- In article <1992Nov20.060539.0430184@locus.com> yazz@locus.com (Bob Yazz) writes:
- >| One issue with selegiline is that it is metabolized to l-methamphetamine
- >| and l-amphetamine, both of which achieve significant levels, and these
- >| both have effects on dopamine reuptake and release.
- >In 10mg/week doses, these "illegal metabolites" are significant only to
- >urine screeners and those affected by them.
-
- I was talking about their therapeutic actions in Parkinsonism.
-
- >By the way, what is the interaction between fluoxetine & deprenyl that
- >Gordon mentioned?
-
- I hadn't heard of any such interaction, though it wouldn't surprise me
- either. It may be the "serotonin syndrome" seen when other MAO inhibitors
- are combined with fluoxetine or meperidine. You get hyperpyrexia, con-
- vulsions, and other nasty, life threatening symptoms.
-
- --
- Steve Dyer
- dyer@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer
-