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- From: dyer@spdcc.com (Steve Dyer)
- Newsgroups: sci.med,alt.support.diet
- Subject: lipase inhibitors
- Message-ID: <1992Nov17.193224.15949@spdcc.com>
- Date: 17 Nov 92 19:32:24 GMT
- Article-I.D.: spdcc.1992Nov17.193224.15949
- References: <1992Nov13.185315.14960@ms.uky.edu> <1992Nov13.212600.21276@inmet.camb.inmet.com> <1992Nov14.052856.2865@spdcc.com>
- Organization: S.P. Dyer Computer Consulting, Cambridge MA
- Lines: 27
-
- >>BTW, anybody else hear about trials of a drug that interferes with fat
- >>digestion? I believe it's called Olistat, and it cause up to 30% of ingested
- >>fat to be excreted undigested. Of course, I read this in that
- >>highly-regarded medical journal Family Circle (or was it Women's Day :-).
-
- If you're in the Boston area, BU is doing a two-year study of this drug,
- a lipase inhibitor, and is recruiting volunteers. Call 617-638-5980 and
- ask about the volunteer study. I've been on a diet and have lost weight,
- so I'm not eligible. (When I called about an obesity study for a different
- drug, sibutramine, a few months ago, I was too heavy for their criteria!
- I just can't win.)
-
- >Like mineral oil and Olestra (sucrose polyester), I wonder if this might
- >cause an, er, cosmetic problem.
-
- In fact, it does cause steatorrhea (fat in the stool), occasionally
- clinically significant. The study will be looking at the drug's
- effects on the levels of fat-soluble vitamins, and other laboratory values.
-
- I don't know anything more about this particular drug, other than
- it may have a generic name "lipostatin" (or something which sounds
- a lot like this--the few published studies refer to tetrahydrolipstatin),
- and that it's being investigated by Hoffmann-La Roche.
-
- --
- Steve Dyer
- dyer@ursa-major.spdcc.com aka {ima,harvard,rayssd,linus,m2c}!spdcc!dyer
-