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|00000590| 00 00 00 00 b7 af 05 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 33 31 30 30 7d |que_ID{Y|RB03100}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 46 61 63 74 6f 72 20 |..$Title|{Factor |
|000005c0| 56 49 49 49 20 52 65 6c | 61 74 65 64 20 41 6e 74 |VIII Rel|ated Ant|
|000005d0| 69 67 65 6e 20 61 6e 64 | 20 43 68 69 6c 64 68 6f |igen and| Childho|
|000005e0| 6f 64 20 52 68 65 75 6d | 61 74 69 63 20 44 69 73 |od Rheum|atic Dis|
|000005f0| 65 61 73 65 73 7d 0d 0a | 24 41 75 74 68 6f 72 7b |eases}..|$Author{|
|00000600| 0d 0a 42 6f 77 79 65 72 | 2c 20 53 4c 0d 0a 52 61 |..Bowyer|, SL..Ra|
|00000610| 67 73 64 61 6c 65 2c 20 | 43 47 0d 0a 53 75 6c 6c |gsdale, |CG..Sull|
|00000620| 69 76 61 6e 2c 20 44 42 | 7d 0d 0a 24 41 66 66 69 |ivan, DB|}..$Affi|
|00000630| 6c 69 61 74 69 6f 6e 7b | 43 68 69 6c 64 72 65 6e |liation{|Children|
|00000640| 27 73 20 48 6f 73 70 20 | 6f 66 20 4c 6f 73 20 41 |'s Hosp |of Los A|
|00000650| 6e 67 65 6c 65 73 3b 20 | 55 6e 69 76 20 6f 66 20 |ngeles; |Univ of |
|00000660| 4d 69 63 68 69 67 61 6e | 7d 0d 0a 24 4a 6f 75 72 |Michigan|}..$Jour|
|00000670| 6e 61 6c 7b 4a 20 52 68 | 65 75 6d 61 74 6f 6c 7d |nal{J Rh|eumatol}|
|00000680| 0d 0a 24 56 6f 6c 75 6d | 65 7b 31 36 7d 0d 0a 24 |..$Volum|e{16}..$|
|00000690| 50 61 67 65 7b 31 30 39 | 33 2d 31 30 39 37 7d 0d |Page{109|3-1097}.|
|000006a0| 0a 24 44 61 74 65 7b 31 | 39 38 39 7d 0d 0a 24 59 |.$Date{1|989}..$Y|
|000006b0| 42 56 6f 6c 7b 31 39 39 | 31 20 59 65 61 72 20 42 |BVol{199|1 Year B|
|000006c0| 6f 6f 6b 20 6f 66 20 50 | 65 64 69 61 74 72 69 63 |ook of P|ediatric|
|000006d0| 73 3a 7d 0d 0a 24 43 68 | 61 70 74 65 72 7b 31 38 |s:}..$Ch|apter{18|
|000006e0| 2d 33 7d 0d 0a 24 59 42 | 45 64 69 74 6f 72 7b 44 |-3}..$YB|Editor{D|
|000006f0| 72 73 2e 20 4f 73 6b 69 | 20 61 6e 64 20 53 74 6f |rs. Oski| and Sto|
|00000700| 63 6b 6d 61 6e 7d 0d 0a | 24 54 61 62 6c 65 7b 54 |ckman}..|$Table{T|
|00000710| 61 62 6c 65 20 4f 6d 69 | 74 74 65 64 7d 0d 0a 24 |able Omi|tted}..$|
|00000720| 43 6f 6d 6d 65 6e 74 61 | 74 6f 72 7b 4a 2e 41 2e |Commenta|tor{J.A.|
|00000730| 20 53 74 6f 63 6b 6d 61 | 6e 2c 20 49 49 49 2c 20 | Stockma|n, III, |
|00000740| 4d 2e 44 2e 7d 0d 0a 0d | 0a 43 6f 70 79 72 69 67 |M.D.}...|.Copyrig|
|00000750| 68 74 20 28 43 29 20 59 | 65 61 72 20 42 6f 6f 6b |ht (C) Y|ear Book|
|00000760| 20 4d 65 64 69 63 61 6c | 20 50 75 62 6c 69 73 68 | Medical| Publish|
|00000770| 65 72 73 2c 20 49 6e 63 | 2e 20 31 39 39 31 0d 0a |ers, Inc|. 1991..|
|00000780| 0d 0a 31 39 39 31 20 59 | 65 61 72 20 42 6f 6f 6b |..1991 Y|ear Book|
|00000790| 20 6f 66 20 50 65 64 69 | 61 74 72 69 63 73 3a 0d | of Pedi|atrics:.|
|000007a0| 0a 0d 0a 43 68 61 70 74 | 65 72 20 31 38 20 2d 2d |...Chapt|er 18 --|
|000007b0| 20 54 68 65 20 4d 75 73 | 63 75 6c 6f 73 6b 65 6c | The Mus|culoskel|
|000007c0| 65 74 61 6c 20 53 79 73 | 74 65 6d 0d 0a 0d 0a 2d |etal Sys|tem....-|
|000007d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 46 |--------|-----..F|
|00000820| 61 63 74 6f 72 20 56 49 | 49 49 20 52 65 6c 61 74 |actor VI|II Relat|
|00000830| 65 64 20 41 6e 74 69 67 | 65 6e 20 61 6e 64 20 43 |ed Antig|en and C|
|00000840| 68 69 6c 64 68 6f 6f 64 | 20 52 68 65 75 6d 61 74 |hildhood| Rheumat|
|00000850| 69 63 20 44 69 73 65 61 | 73 65 73 0d 0a 0d 0a 42 |ic Disea|ses....B|
|00000860| 6f 77 79 65 72 20 53 4c | 3b 20 52 61 67 73 64 61 |owyer SL|; Ragsda|
|00000870| 6c 65 20 43 47 3b 20 53 | 75 6c 6c 69 76 61 6e 20 |le CG; S|ullivan |
|00000880| 44 42 0d 0a 28 43 68 69 | 6c 64 72 65 6e 27 73 20 |DB..(Chi|ldren's |
|00000890| 48 6f 73 70 20 6f 66 20 | 4c 6f 73 20 41 6e 67 65 |Hosp of |Los Ange|
|000008a0| 6c 65 73 3b 20 55 6e 69 | 76 20 6f 66 20 4d 69 63 |les; Uni|v of Mic|
|000008b0| 68 69 67 61 6e 29 0d 0a | 4a 20 52 68 65 75 6d 61 |higan)..|J Rheuma|
|000008c0| 74 6f 6c 20 31 36 3a 31 | 30 39 33 2d 31 30 39 37 |tol 16:1|093-1097|
|000008d0| 2c 20 31 39 38 39 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1989..|--------|
|000008e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000920| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00000930| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 48 69 67 68 20 |ct....  |   High |
|00000940| 6c 65 76 65 6c 73 20 6f | 66 20 66 61 63 74 6f 72 |levels o|f factor|
|00000950| 20 56 49 49 49 2d 72 65 | 6c 61 74 65 64 20 61 6e | VIII-re|lated an|
|00000960| 74 69 67 65 6e 20 28 46 | 56 49 49 49 52 41 67 29 |tigen (F|VIIIRAg)|
|00000970| 2c 20 61 6c 73 6f 20 6b | 6e 6f 77 6e 20 61 73 20 |, also k|nown as |
|00000980| 76 6f 6e 0d 0a 57 69 6c | 6c 65 62 72 61 6e 64 27 |von..Wil|lebrand'|
|00000990| 73 20 66 61 63 74 6f 72 | 2c 20 68 61 76 65 20 62 |s factor|, have b|
|000009a0| 65 65 6e 20 72 65 70 6f | 72 74 65 64 20 69 6e 20 |een repo|rted in |
|000009b0| 63 6f 6e 64 69 74 69 6f | 6e 73 20 74 68 61 74 20 |conditio|ns that |
|000009c0| 69 6e 76 6f 6c 76 65 20 | 69 6e 6a 75 72 79 20 74 |involve |injury t|
|000009d0| 6f 0d 0a 76 61 73 63 75 | 6c 61 72 20 65 6e 64 6f |o..vascu|lar endo|
|000009e0| 74 68 65 6c 69 75 6d 2e | 20 20 52 68 65 75 6d 61 |thelium.|  Rheuma|
|000009f0| 74 69 63 20 64 69 73 65 | 61 73 65 73 20 69 6e 20 |tic dise|ases in |
|00000a00| 63 68 69 6c 64 72 65 6e | 20 66 72 65 71 75 65 6e |children| frequen|
|00000a10| 74 6c 79 20 68 61 76 65 | 20 61 0d 0a 76 61 73 63 |tly have| a..vasc|
|00000a20| 75 6c 69 74 69 63 20 63 | 6f 6d 70 6f 6e 65 6e 74 |ulitic c|omponent|
|00000a30| 2c 20 61 6e 64 20 6d 65 | 61 73 75 72 65 6d 65 6e |, and me|asuremen|
|00000a40| 74 20 6f 66 20 74 68 65 | 20 46 56 49 49 49 52 41 |t of the| FVIIIRA|
|00000a50| 67 20 6c 65 76 65 6c 20 | 69 6e 20 74 68 65 20 62 |g level |in the b|
|00000a60| 6c 6f 6f 64 20 6d 61 79 | 0d 0a 62 65 20 75 73 65 |lood may|..be use|
|00000a70| 66 75 6c 20 69 6e 20 6d | 6f 6e 69 74 6f 72 69 6e |ful in m|onitorin|
|00000a80| 67 20 64 69 73 65 61 73 | 65 20 61 63 74 69 76 69 |g diseas|e activi|
|00000a90| 74 79 2e 20 20 46 61 63 | 74 6f 72 20 56 49 49 49 |ty.  Fac|tor VIII|
|00000aa0| 52 41 67 20 6c 65 76 65 | 6c 73 20 77 65 72 65 20 |RAg leve|ls were |
|00000ab0| 6d 65 61 73 75 72 65 64 | 0d 0a 69 6e 20 74 68 65 |measured|..in the|
|00000ac0| 20 70 6c 61 73 6d 61 20 | 6f 66 20 36 33 20 63 68 | plasma |of 63 ch|
|00000ad0| 69 6c 64 72 65 6e 20 77 | 69 74 68 20 76 61 72 69 |ildren w|ith vari|
|00000ae0| 6f 75 73 20 72 68 65 75 | 6d 61 74 69 63 20 64 69 |ous rheu|matic di|
|00000af0| 73 65 61 73 65 73 20 61 | 6e 64 20 69 6e 20 32 30 |seases a|nd in 20|
|00000b00| 0d 0a 63 6f 6e 74 72 6f | 6c 73 2e 20 20 54 68 65 |..contro|ls.  The|
|00000b10| 20 72 65 73 75 6c 74 73 | 20 77 65 72 65 20 63 6f | results| were co|
|00000b20| 6d 70 61 72 65 64 20 77 | 69 74 68 20 72 65 73 75 |mpared w|ith resu|
|00000b30| 6c 74 73 20 6f 66 20 6c | 61 62 6f 72 61 74 6f 72 |lts of l|aborator|
|00000b40| 79 20 74 65 73 74 73 0d | 0a 66 72 65 71 75 65 6e |y tests.|.frequen|
|00000b50| 74 6c 79 20 75 73 65 64 | 20 74 6f 20 6d 6f 6e 69 |tly used| to moni|
|00000b60| 74 6f 72 20 64 69 73 65 | 61 73 65 20 61 63 74 69 |tor dise|ase acti|
|00000b70| 76 69 74 79 20 69 6e 20 | 74 68 65 73 65 20 70 61 |vity in |these pa|
|00000b80| 74 69 65 6e 74 73 20 61 | 6e 64 20 74 6f 20 6c 65 |tients a|nd to le|
|00000b90| 76 65 6c 73 20 6f 66 0d | 0a 70 6c 61 74 65 6c 65 |vels of.|.platele|
|00000ba0| 74 73 20 61 6e 64 20 61 | 63 75 74 65 20 70 68 61 |ts and a|cute pha|
|00000bb0| 73 65 20 72 65 61 63 74 | 61 6e 74 73 2c 20 43 2d |se react|ants, C-|
|00000bc0| 72 65 61 63 74 69 76 65 | 20 70 72 6f 74 65 69 6e |reactive| protein|
|00000bd0| 2c 20 61 6e 64 20 66 69 | 62 72 69 6e 6f 67 65 6e |, and fi|brinogen|
|00000be0| 2e 0d 0a 20 20 20 20 20 | 48 69 67 68 20 6c 65 76 |...     |High lev|
|00000bf0| 65 6c 73 20 6f 66 20 46 | 56 49 49 49 52 41 67 20 |els of F|VIIIRAg |
|00000c00| 77 65 72 65 20 66 6f 75 | 6e 64 20 69 6e 20 70 61 |were fou|nd in pa|
|00000c10| 74 69 65 6e 74 73 20 77 | 69 74 68 20 73 79 73 74 |tients w|ith syst|
|00000c20| 65 6d 69 63 20 6a 75 76 | 65 6e 69 6c 65 0d 0a 61 |emic juv|enile..a|
|00000c30| 72 74 68 72 69 74 69 73 | 2c 20 73 79 73 74 65 6d |rthritis|, system|
|00000c40| 69 63 20 6c 75 70 75 73 | 20 65 72 79 74 68 65 6d |ic lupus| erythem|
|00000c50| 61 74 6f 73 75 73 2c 20 | 6a 75 76 65 6e 69 6c 65 |atosus, |juvenile|
|00000c60| 20 64 65 72 6d 61 74 6f | 6d 79 6f 73 69 74 69 73 | dermato|myositis|
|00000c70| 20 28 44 4d 29 2c 20 61 | 6e 64 0d 0a 73 79 73 74 | (DM), a|nd..syst|
|00000c80| 65 6d 69 63 20 76 61 73 | 63 75 6c 69 74 69 73 20 |emic vas|culitis |
|00000c90| 28 46 69 67 20 31 38 2d | 31 29 2e 20 20 54 68 65 |(Fig 18-|1).  The|
|00000ca0| 73 65 20 6c 65 76 65 6c | 73 20 64 69 66 66 65 72 |se level|s differ|
|00000cb0| 65 64 20 73 69 67 6e 69 | 66 69 63 61 6e 74 6c 79 |ed signi|ficantly|
|00000cc0| 20 66 72 6f 6d 0d 0a 74 | 68 6f 73 65 20 6f 66 20 | from..t|hose of |
|00000cd0| 63 6f 6e 74 72 6f 6c 20 | 70 61 74 69 65 6e 74 73 |control |patients|
|00000ce0| 2e 20 20 4c 65 76 65 6c | 73 20 6f 66 20 46 56 49 |.  Level|s of FVI|
|00000cf0| 49 49 52 41 67 20 64 69 | 64 20 6e 6f 74 20 63 6f |IIRAg di|d not co|
|00000d00| 72 72 65 6c 61 74 65 20 | 77 69 74 68 20 6c 65 76 |rrelate |with lev|
|00000d10| 65 6c 73 0d 0a 6f 66 20 | 65 72 79 74 68 72 6f 63 |els..of |erythroc|
|00000d20| 79 74 65 20 73 65 64 69 | 6d 65 6e 74 61 74 69 6f |yte sedi|mentatio|
|00000d30| 6e 20 72 61 74 65 2c 20 | 43 2d 72 65 61 63 74 69 |n rate, |C-reacti|
|00000d40| 76 65 20 70 72 6f 74 65 | 69 6e 2c 20 61 6e 64 20 |ve prote|in, and |
|00000d50| 66 69 62 72 69 6e 6f 67 | 65 6e 2c 0d 0a 73 75 67 |fibrinog|en,..sug|
|00000d60| 67 65 73 74 69 6e 67 20 | 74 68 61 74 20 46 56 49 |gesting |that FVI|
|00000d70| 49 49 52 41 67 20 77 61 | 73 20 6e 6f 74 20 6a 75 |IIRAg wa|s not ju|
|00000d80| 73 74 20 61 6e 6f 74 68 | 65 72 20 61 63 75 74 65 |st anoth|er acute|
|00000d90| 20 70 68 61 73 65 20 72 | 65 61 63 74 61 6e 74 2e | phase r|eactant.|
|00000da0| 0d 0a 20 20 20 20 20 4c | 65 76 65 6c 73 20 6f 66 |..     L|evels of|
|00000db0| 20 46 56 49 49 49 52 41 | 67 20 61 72 65 20 65 6c | FVIIIRA|g are el|
|00000dc0| 65 76 61 74 65 64 20 69 | 6e 20 70 61 74 69 65 6e |evated i|n patien|
|00000dd0| 74 73 20 77 69 74 68 20 | 63 68 69 6c 64 68 6f 6f |ts with |childhoo|
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|00002980| 68 6f 72 7b 0d 0a 4b 65 | 6c 6c 79 2c 20 4c 4a 0d |hor{..Ke|lly, LJ.|
|00002990| 0a 47 61 72 6c 61 6e 64 | 2c 20 4a 53 0d 0a 54 61 |.Garland|, JS..Ta|
|000029a0| 6e 67 2c 20 54 54 0d 0a | 53 68 75 67 2c 20 41 4c |ng, TT..|Shug, AL|
|000029b0| 0d 0a 43 68 75 73 69 64 | 2c 20 4d 4a 7d 0d 0a 24 |..Chusid|, MJ}..$|
|000029c0| 41 66 66 69 6c 69 61 74 | 69 6f 6e 7b 43 68 69 6c |Affiliat|ion{Chil|
|000029d0| 64 72 65 6e 27 73 20 48 | 6f 73 70 20 6f 66 20 57 |dren's H|osp of W|
|000029e0| 69 73 63 6f 6e 73 69 6e | 2c 20 4d 65 64 20 43 6f |isconsin|, Med Co|
|000029f0| 6c 6c 65 67 65 20 6f 66 | 20 57 69 73 63 6f 6e 73 |llege of| Wiscons|
|00002a00| 69 6e 2c 20 4d 69 6c 77 | 61 75 6b 65 65 7d 0d 0a |in, Milw|aukee}..|
|00002a10| 24 4a 6f 75 72 6e 61 6c | 7b 50 65 64 69 61 74 72 |$Journal|{Pediatr|
|00002a20| 69 63 73 7d 0d 0a 24 56 | 6f 6c 75 6d 65 7b 38 34 |ics}..$V|olume{84|
|00002a30| 7d 0d 0a 24 50 61 67 65 | 7b 33 31 32 2d 33 31 36 |}..$Page|{312-316|
|00002a40| 7d 0d 0a 24 44 61 74 65 | 7b 31 39 38 39 7d 0d 0a |}..$Date|{1989}..|
|00002a50| 24 59 42 56 6f 6c 7b 31 | 39 39 31 20 59 65 61 72 |$YBVol{1|991 Year|
|00002a60| 20 42 6f 6f 6b 20 6f 66 | 20 50 65 64 69 61 74 72 | Book of| Pediatr|
|00002a70| 69 63 73 3a 7d 0d 0a 24 | 43 68 61 70 74 65 72 7b |ics:}..$|Chapter{|
|00002a80| 31 38 2d 35 7d 0d 0a 24 | 59 42 45 64 69 74 6f 72 |18-5}..$|YBEditor|
|00002a90| 7b 44 72 73 2e 20 4f 73 | 6b 69 20 61 6e 64 20 53 |{Drs. Os|ki and S|
|00002aa0| 74 6f 63 6b 6d 61 6e 7d | 0d 0a 24 54 61 62 6c 65 |tockman}|..$Table|
|00002ab0| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|00002ac0| 7b 4a 2e 41 2e 20 53 74 | 6f 63 6b 6d 61 6e 2c 20 |{J.A. St|ockman, |
|00002ad0| 49 49 49 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |III, M.D|.}....Co|
|00002ae0| 70 79 72 69 67 68 74 20 | 28 43 29 20 59 65 61 72 |pyright |(C) Year|
|00002af0| 20 42 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 | Book Me|dical Pu|
|00002b00| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 20 31 |blishers|, Inc. 1|
|00002b10| 39 39 31 0d 0a 0d 0a 31 | 39 39 31 20 59 65 61 72 |991....1|991 Year|
|00002b20| 20 42 6f 6f 6b 20 6f 66 | 20 50 65 64 69 61 74 72 | Book of| Pediatr|
|00002b30| 69 63 73 3a 0d 0a 0d 0a | 43 68 61 70 74 65 72 20 |ics:....|Chapter |
|00002b40| 31 38 20 2d 2d 20 54 68 | 65 20 4d 75 73 63 75 6c |18 -- Th|e Muscul|
|00002b50| 6f 73 6b 65 6c 65 74 61 | 6c 20 53 79 73 74 65 6d |oskeleta|l System|
|00002b60| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|00002b70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002b90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ba0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002bb0| 2d 2d 0d 0a 46 61 74 61 | 6c 20 52 68 61 62 64 6f |--..Fata|l Rhabdo|
|00002bc0| 6d 79 6f 6c 79 73 69 73 | 20 46 6f 6c 6c 6f 77 69 |myolysis| Followi|
|00002bd0| 6e 67 20 49 6e 66 6c 75 | 65 6e 7a 61 20 49 6e 66 |ng Influ|enza Inf|
|00002be0| 65 63 74 69 6f 6e 20 69 | 6e 20 61 20 47 69 72 6c |ection i|n a Girl|
|00002bf0| 20 57 69 74 68 20 46 61 | 6d 69 6c 69 61 6c 0d 0a | With Fa|milial..|
|00002c00| 43 61 72 6e 69 74 69 6e | 65 20 50 61 6c 6d 69 74 |Carnitin|e Palmit|
|00002c10| 79 6c 20 54 72 61 6e 73 | 66 65 72 61 73 65 20 44 |yl Trans|ferase D|
|00002c20| 65 66 69 63 69 65 6e 63 | 79 0d 0a 0d 0a 4b 65 6c |eficienc|y....Kel|
|00002c30| 6c 79 20 4c 4a 3b 20 47 | 61 72 6c 61 6e 64 20 4a |ly LJ; G|arland J|
|00002c40| 53 3b 20 54 61 6e 67 20 | 54 54 3b 20 53 68 75 67 |S; Tang |TT; Shug|
|00002c50| 20 41 4c 3b 20 43 68 75 | 73 69 64 20 4d 4a 0d 0a | AL; Chu|sid MJ..|
|00002c60| 28 43 68 69 6c 64 72 65 | 6e 27 73 20 48 6f 73 70 |(Childre|n's Hosp|
|00002c70| 20 6f 66 20 57 69 73 63 | 6f 6e 73 69 6e 2c 20 4d | of Wisc|onsin, M|
|00002c80| 65 64 20 43 6f 6c 6c 65 | 67 65 20 6f 66 20 57 69 |ed Colle|ge of Wi|
|00002c90| 73 63 6f 6e 73 69 6e 2c | 20 4d 69 6c 77 61 75 6b |sconsin,| Milwauk|
|00002ca0| 65 65 29 0d 0a 50 65 64 | 69 61 74 72 69 63 73 20 |ee)..Ped|iatrics |
|00002cb0| 38 34 3a 33 31 32 2d 33 | 31 36 2c 20 31 39 38 39 |84:312-3|16, 1989|
|00002cc0| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|00002cd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ce0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002cf0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002d00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002d10| 0d 0a 0d 0a 41 62 73 74 | 72 61 63 74 0d 0a 0d 0a |....Abst|ract....|
|00002d20| 20 20 20 20 20 4d 79 6f | 67 6c 6f 62 69 6e 2d 69 |     Myo|globin-i|
|00002d30| 6e 64 75 63 65 64 20 72 | 65 6e 61 6c 20 66 61 69 |nduced r|enal fai|
|00002d40| 6c 75 72 65 20 6f 63 63 | 75 72 72 65 64 20 61 66 |lure occ|urred af|
|00002d50| 74 65 72 20 61 6e 20 69 | 6e 66 6c 75 65 6e 7a 61 |ter an i|nfluenza|
|00002d60| 20 69 6e 66 65 63 74 69 | 6f 6e 20 69 6e 0d 0a 61 | infecti|on in..a|
|00002d70| 20 70 72 65 76 69 6f 75 | 73 6c 79 20 68 65 61 6c | previou|sly heal|
|00002d80| 74 68 79 20 63 68 69 6c | 64 20 77 69 74 68 20 63 |thy chil|d with c|
|00002d90| 61 72 6e 69 74 69 6e 65 | 20 70 61 6c 6d 69 74 79 |arnitine| palmity|
|00002da0| 6c 20 74 72 61 6e 73 66 | 65 72 61 73 65 20 64 65 |l transf|erase de|
|00002db0| 66 69 63 69 65 6e 63 79 | 2e 0d 0a 0d 0a 20 20 20 |ficiency|.....   |
|00002dc0| 20 20 47 69 72 6c 2c 20 | 31 33 20 79 65 61 72 73 |  Girl, |13 years|
|00002dd0| 2c 20 68 61 64 20 73 65 | 76 65 72 65 20 72 68 61 |, had se|vere rha|
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|00002e20| 20 73 65 76 65 72 65 6c | 79 20 72 65 73 74 72 69 | severel|y restri|
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|00002e50| 20 54 68 65 0d 0a 63 6c | 69 6e 69 63 61 6c 20 63 | The..cl|inical c|
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|00002e70| 63 61 74 65 64 20 62 79 | 20 65 70 69 73 6f 64 65 |cated by| episode|
|00002e80| 73 20 6f 66 20 73 65 76 | 65 72 65 20 68 79 70 65 |s of sev|ere hype|
|00002e90| 72 6b 61 6c 65 6d 69 61 | 2c 0d 0a 68 79 70 6f 63 |rkalemia|,..hypoc|
|00002ea0| 61 6c 63 65 6d 69 61 2c | 20 68 79 70 65 72 70 68 |alcemia,| hyperph|
|00002eb0| 6f 73 70 68 61 74 65 6d | 69 61 2c 20 61 6e 64 20 |osphatem|ia, and |
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|00002ed0| 52 65 6e 61 6c 20 66 61 | 69 6c 75 72 65 2c 0d 0a |Renal fa|ilure,..|
|00002ee0| 68 79 70 65 72 74 65 6e | 73 69 6f 6e 2c 20 61 6e |hyperten|sion, an|
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|00002f10| 63 63 75 72 72 65 64 2c | 20 61 6e 64 20 74 68 65 |ccurred,| and the|
|00002f20| 20 70 61 74 69 65 6e 74 | 20 64 69 65 64 2e 0d 0a | patient| died...|
|00002f30| 4d 75 73 63 6c 65 20 62 | 69 6f 70 73 79 20 73 70 |Muscle b|iopsy sp|
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|00003080| 62 64 6f 6d 79 6f 6c 79 | 73 69 73 20 61 6e 64 0d |bdomyoly|sis and.|
|00003090| 0a 6d 79 6f 67 6c 6f 62 | 69 6e 75 72 69 61 20 6d |.myoglob|inuria m|
|000030a0| 61 79 20 66 6f 6c 6c 6f | 77 20 61 6e 79 20 69 6e |ay follo|w any in|
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|000030d0| 64 20 69 6e 74 61 6b 65 | 2e 0d 0a 52 65 6e 61 6c |d intake|...Renal|
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|00003160| 20 73 69 62 6c 69 6e 67 | 73 20 6f 66 0d 0a 70 72 | sibling|s of..pr|
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|00005370| 65 72 73 2c 20 49 6e 63 | 2e 20 31 39 39 31 0d 0a |ers, Inc|. 1991..|
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|000053d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000053f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005400| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005410| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 43 |--------|-----..C|
|00005420| 6f 6e 67 65 6e 69 74 61 | 6c 20 4d 75 73 63 75 6c |ongenita|l Muscul|
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|000054d0| 20 4f 74 6f 6c 61 72 79 | 6e 67 6f 6c 20 48 65 61 | Otolary|ngol Hea|
|000054e0| 64 20 4e 65 63 6b 20 53 | 75 72 67 20 31 31 36 3a |d Neck S|urg 116:|
|000054f0| 32 31 32 2d 32 31 36 2c | 20 31 39 39 30 0d 0a 2d |212-216,| 1990..-|
|00005500| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005510| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005520| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005530| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005540| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 0d |--------|-----...|
|00005550| 0a 41 62 73 74 72 61 63 | 74 0d 0a 0d 0a 20 20 20 |.Abstrac|t....   |
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|00006350| 7b 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |{1991 Ye|ar Book |
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+--------+-------------------------+-------------------------+--------+--------+