home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-05 | 406.9 KB |
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MacOS 8.1
|
Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
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|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000310| 10 72 03 00 95 0c 00 00 | 35 35 00 00 00 01 a5 7e |.r......|55.....~|
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|00000380| 1d ee 03 00 00 09 00 00 | 36 33 00 00 00 01 1d f7 |........|63......|
|00000390| 03 00 53 0e 00 00 36 34 | 00 00 00 01 70 05 04 00 |..S...64|....p...|
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|000003c0| 36 37 00 00 00 01 fd 36 | 04 00 56 11 00 00 36 38 |67.....6|..V...68|
|000003d0| 00 00 00 01 53 48 04 00 | c6 0f 00 00 36 39 00 00 |....SH..|....69..|
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|000003f0| ef 66 04 00 5b 0f 00 00 | 37 31 00 00 00 01 4a 76 |.f..[...|71....Jv|
|00000400| 04 00 dd 0c 00 00 37 32 | 00 00 00 01 27 83 04 00 |......72|....'...|
|00000410| 28 0f 00 00 37 33 00 00 | 00 01 4f 92 04 00 79 0e |(...73..|..O...y.|
|00000420| 00 00 37 34 00 00 00 01 | c8 a0 04 00 dc 0d 00 00 |..74....|........|
|00000430| 37 35 00 00 00 01 a4 ae | 04 00 d6 11 00 00 37 36 |75......|......76|
|00000440| 00 00 00 01 7a c0 04 00 | 60 0f 00 00 37 37 00 00 |....z...|`...77..|
|00000450| 00 01 da cf 04 00 5c 0f | 00 00 37 38 00 00 00 01 |......\.|..78....|
|00000460| 36 df 04 00 16 10 00 00 | 37 39 00 00 00 01 4c ef |6.......|79....L.|
|00000470| 04 00 1f 11 00 00 38 30 | 00 00 00 01 6b 00 05 00 |......80|....k...|
|00000480| 18 11 00 00 38 31 00 00 | 00 01 83 11 05 00 10 18 |....81..|........|
|00000490| 00 00 38 32 00 00 00 01 | 93 29 05 00 ed 11 00 00 |..82....|.)......|
|000004a0| 38 33 00 00 00 01 80 3b | 05 00 de 11 00 00 38 34 |83.....;|......84|
|000004b0| 00 00 00 01 5e 4d 05 00 | d3 0c 00 00 38 35 00 00 |....^M..|....85..|
|000004c0| 00 01 31 5a 05 00 c6 10 | 00 00 38 36 00 00 00 01 |..1Z....|..86....|
|000004d0| f7 6a 05 00 57 0f 00 00 | 38 37 00 00 00 01 4e 7a |.j..W...|87....Nz|
|000004e0| 05 00 e9 15 00 00 38 38 | 00 00 00 01 37 90 05 00 |......88|....7...|
|000004f0| 85 0f 00 00 38 39 00 00 | 00 01 bc 9f 05 00 32 10 |....89..|......2.|
|00000500| 00 00 39 30 00 00 00 01 | ee af 05 00 f3 0f 00 00 |..90....|........|
|00000510| 39 31 00 00 00 01 e1 bf | 05 00 55 0f 00 00 39 32 |91......|..U...92|
|00000520| 00 00 00 01 36 cf 05 00 | 89 11 00 00 39 33 00 00 |....6...|....93..|
|00000530| 00 01 bf e0 05 00 c4 12 | 00 00 39 34 00 00 00 01 |........|..94....|
|00000540| 83 f3 05 00 48 1a 00 00 | 39 35 00 00 00 01 cb 0d |....H...|95......|
|00000550| 06 00 eb 0e 00 00 39 36 | 00 00 00 01 b6 1c 06 00 |......96|........|
|00000560| 9c 0a 00 00 39 37 00 00 | 00 01 52 27 06 00 9e 10 |....97..|..R'....|
|00000570| 00 00 39 38 00 00 00 01 | f0 37 06 00 d3 10 00 00 |..98....|.7......|
|00000580| 39 39 00 00 00 01 c3 48 | 06 00 c1 12 00 00 00 00 |99.....H|........|
|00000590| 00 00 00 00 84 5b 06 00 | 00 00 00 00 24 55 6e 69 |.....[..|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 32 31 30 30 7d |que_ID{Y|RB02100}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 49 6d 6d 75 6e 6f 63 |..$Title|{Immunoc|
|000005c0| 68 65 6d 69 63 61 6c 20 | 43 68 61 72 61 63 74 65 |hemical |Characte|
|000005d0| 72 69 7a 61 74 69 6f 6e | 20 6f 66 20 43 69 72 63 |rization| of Circ|
|000005e0| 75 6c 61 74 69 6e 67 20 | 50 61 72 61 74 68 79 72 |ulating |Parathyr|
|000005f0| 6f 69 64 0d 0a 48 6f 72 | 6d 6f 6e 65 2d 52 65 6c |oid..Hor|mone-Rel|
|00000600| 61 74 65 64 20 50 72 6f | 74 65 69 6e 73 20 69 6e |ated Pro|teins in|
|00000610| 20 50 61 74 69 65 6e 74 | 73 20 57 69 74 68 20 48 | Patient|s With H|
|00000620| 75 6d 6f 72 61 6c 20 48 | 79 70 65 72 63 61 6c 63 |umoral H|ypercalc|
|00000630| 65 6d 69 61 20 6f 66 20 | 43 61 6e 63 65 72 7d 0d |emia of |Cancer}.|
|00000640| 0a 24 41 75 74 68 6f 72 | 7b 0d 0a 42 75 72 74 69 |.$Author|{..Burti|
|00000650| 73 2c 20 57 4a 0d 0a 42 | 72 61 64 79 2c 20 54 47 |s, WJ..B|rady, TG|
|00000660| 0d 0a 4f 72 6c 6f 66 66 | 2c 20 4a 4a 0d 0a 45 72 |..Orloff|, JJ..Er|
|00000670| 73 62 61 6b 2c 20 4a 42 | 0d 0a 57 61 72 72 65 6c |sbak, JB|..Warrel|
|00000680| 6c 2c 20 52 50 2c 20 4a | 72 0d 0a 4f 6c 73 6f 6e |l, RP, J|r..Olson|
|00000690| 2c 20 42 52 0d 0a 57 75 | 2c 20 54 4c 0d 0a 4d 69 |, BR..Wu|, TL..Mi|
|000006a0| 74 6e 69 63 6b 2c 20 4d | 45 0d 0a 42 72 6f 61 64 |tnick, M|E..Broad|
|000006b0| 75 73 2c 20 41 45 0d 0a | 53 74 65 77 61 72 74 2c |us, AE..|Stewart,|
|000006c0| 20 41 46 7d 0d 0a 24 41 | 66 66 69 6c 69 61 74 69 | AF}..$A|ffiliati|
|000006d0| 6f 6e 7b 57 65 73 74 20 | 48 61 76 65 6e 20 56 65 |on{West |Haven Ve|
|000006e0| 74 65 72 61 6e 73 20 41 | 66 66 61 69 72 73 20 4d |terans A|ffairs M|
|000006f0| 65 64 20 43 74 72 2c 20 | 57 65 73 74 20 48 61 76 |ed Ctr, |West Hav|
|00000700| 65 6e 2c 20 43 6f 6e 6e | 3b 20 59 61 6c 65 20 55 |en, Conn|; Yale U|
|00000710| 6e 69 76 3b 0d 0a 4d 65 | 6d 20 53 6c 6f 61 6e 2d |niv;..Me|m Sloan-|
|00000720| 4b 65 74 74 65 72 69 6e | 67 20 43 61 6e 63 65 72 |Ketterin|g Cancer|
|00000730| 20 43 74 72 2c 20 4e 65 | 77 20 59 6f 72 6b 3b 20 | Ctr, Ne|w York; |
|00000740| 43 6f 72 6e 65 6c 6c 20 | 55 6e 69 76 3b 20 55 6e |Cornell |Univ; Un|
|00000750| 69 76 20 6f 66 20 50 69 | 74 74 73 62 75 72 67 68 |iv of Pi|ttsburgh|
|00000760| 7d 0d 0a 24 4a 6f 75 72 | 6e 61 6c 7b 4e 20 45 6e |}..$Jour|nal{N En|
|00000770| 67 6c 20 4a 20 4d 65 64 | 7d 0d 0a 24 56 6f 6c 75 |gl J Med|}..$Volu|
|00000780| 6d 65 7b 33 32 32 7d 0d | 0a 24 50 61 67 65 7b 31 |me{322}.|.$Page{1|
|00000790| 31 30 36 2d 31 31 31 32 | 7d 0d 0a 24 44 61 74 65 |106-1112|}..$Date|
|000007a0| 7b 31 39 39 30 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 |{1990}..|$YBVol{1|
|000007b0| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|000007c0| 20 4d 65 64 69 63 69 6e | 65 7d 0d 0a 24 43 68 61 | Medicin|e}..$Cha|
|000007d0| 70 74 65 72 7b 34 33 2d | 32 7d 0d 0a 24 59 42 45 |pter{43-|2}..$YBE|
|000007e0| 64 69 74 6f 72 7b 44 72 | 73 2e 20 52 6f 67 65 72 |ditor{Dr|s. Roger|
|000007f0| 73 2c 20 44 65 73 20 50 | 72 65 7a 2c 20 43 6c 69 |s, Des P|rez, Cli|
|00000800| 6e 65 2c 20 42 72 61 75 | 6e 77 61 6c 64 2c 20 47 |ne, Brau|nwald, G|
|00000810| 72 65 65 6e 62 65 72 67 | 65 72 2c 20 55 74 69 67 |reenberg|er, Utig|
|00000820| 65 72 2c 0d 0a 45 70 73 | 74 65 69 6e 2c 20 61 6e |er,..Eps|tein, an|
|00000830| 64 20 4d 61 6c 61 77 69 | 73 74 61 7d 0d 0a 24 54 |d Malawi|sta}..$T|
|00000840| 61 62 6c 65 7b 54 61 62 | 6c 65 20 4f 6d 69 74 74 |able{Tab|le Omitt|
|00000850| 65 64 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |ed}..$Co|mmentato|
|00000860| 72 7b 52 2e 44 2e 20 55 | 74 69 67 65 72 2c 20 4d |r{R.D. U|tiger, M|
|00000870| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00000880| 74 20 28 43 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (C) Ye|ar Book |
|00000890| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|000008a0| 72 73 2c 20 49 6e 63 2e | 20 31 39 39 31 0d 0a 0d |rs, Inc.| 1991...|
|000008b0| 0a 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1991 Ye|ar Book |
|000008c0| 6f 66 20 4d 65 64 69 63 | 69 6e 65 0d 0a 0d 0a 50 |of Medic|ine....P|
|000008d0| 61 72 74 20 53 69 78 20 | 2d 2d 20 45 6e 64 6f 63 |art Six |-- Endoc|
|000008e0| 72 69 6e 6f 6c 6f 67 79 | 20 61 6e 64 20 4d 65 74 |rinology| and Met|
|000008f0| 61 62 6f 6c 69 73 6d 0d | 0a 0d 0a 43 68 61 70 74 |abolism.|...Chapt|
|00000900| 65 72 20 34 33 20 2d 2d | 20 54 68 65 20 50 61 72 |er 43 --| The Par|
|00000910| 61 74 68 79 72 6f 69 64 | 20 47 6c 61 6e 64 73 20 |athyroid| Glands |
|00000920| 61 6e 64 20 42 6f 6e 65 | 0d 0a 0d 0a 2d 2d 2d 2d |and Bone|....----|
|00000930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 49 6d 6d 75 |--------|--..Immu|
|00000980| 6e 6f 63 68 65 6d 69 63 | 61 6c 20 43 68 61 72 61 |nochemic|al Chara|
|00000990| 63 74 65 72 69 7a 61 74 | 69 6f 6e 20 6f 66 20 43 |cterizat|ion of C|
|000009a0| 69 72 63 75 6c 61 74 69 | 6e 67 20 50 61 72 61 74 |irculati|ng Parat|
|000009b0| 68 79 72 6f 69 64 20 48 | 6f 72 6d 6f 6e 65 2d 52 |hyroid H|ormone-R|
|000009c0| 65 6c 61 74 65 64 0d 0a | 50 72 6f 74 65 69 6e 73 |elated..|Proteins|
|000009d0| 20 69 6e 20 50 61 74 69 | 65 6e 74 73 20 57 69 74 | in Pati|ents Wit|
|000009e0| 68 20 48 75 6d 6f 72 61 | 6c 20 48 79 70 65 72 63 |h Humora|l Hyperc|
|000009f0| 61 6c 63 65 6d 69 61 20 | 6f 66 20 43 61 6e 63 65 |alcemia |of Cance|
|00000a00| 72 0d 0a 0d 0a 42 75 72 | 74 69 73 20 57 4a 3b 20 |r....Bur|tis WJ; |
|00000a10| 42 72 61 64 79 20 54 47 | 3b 20 4f 72 6c 6f 66 66 |Brady TG|; Orloff|
|00000a20| 20 4a 4a 3b 20 45 72 73 | 62 61 6b 20 4a 42 3b 20 | JJ; Ers|bak JB; |
|00000a30| 57 61 72 72 65 6c 6c 20 | 52 50 20 4a 72 3b 20 4f |Warrell |RP Jr; O|
|00000a40| 6c 73 6f 6e 20 42 52 3b | 20 57 75 20 54 4c 3b 0d |lson BR;| Wu TL;.|
|00000a50| 0a 4d 69 74 6e 69 63 6b | 20 4d 45 3b 20 42 72 6f |.Mitnick| ME; Bro|
|00000a60| 61 64 75 73 20 41 45 3b | 20 53 74 65 77 61 72 74 |adus AE;| Stewart|
|00000a70| 20 41 46 0d 0a 28 57 65 | 73 74 20 48 61 76 65 6e | AF..(We|st Haven|
|00000a80| 20 56 65 74 65 72 61 6e | 73 20 41 66 66 61 69 72 | Veteran|s Affair|
|00000a90| 73 20 4d 65 64 20 43 74 | 72 2c 20 57 65 73 74 20 |s Med Ct|r, West |
|00000aa0| 48 61 76 65 6e 2c 20 43 | 6f 6e 6e 3b 20 59 61 6c |Haven, C|onn; Yal|
|00000ab0| 65 20 55 6e 69 76 3b 20 | 4d 65 6d 0d 0a 53 6c 6f |e Univ; |Mem..Slo|
|00000ac0| 61 6e 2d 4b 65 74 74 65 | 72 69 6e 67 20 43 61 6e |an-Kette|ring Can|
|00000ad0| 63 65 72 20 43 74 72 2c | 20 4e 65 77 20 59 6f 72 |cer Ctr,| New Yor|
|00000ae0| 6b 3b 20 43 6f 72 6e 65 | 6c 6c 20 55 6e 69 76 3b |k; Corne|ll Univ;|
|00000af0| 20 55 6e 69 76 20 6f 66 | 20 50 69 74 74 73 62 75 | Univ of| Pittsbu|
|00000b00| 72 67 68 29 20 4e 20 45 | 6e 67 6c 0d 0a 4a 20 4d |rgh) N E|ngl..J M|
|00000b10| 65 64 20 33 32 32 3a 31 | 31 30 36 2d 31 31 31 32 |ed 322:1|106-1112|
|00000b20| 2c 20 31 39 39 30 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1990..|--------|
|00000b30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000b40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000b50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000b60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000b70| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00000b80| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 41 20 70 61 72 |ct.... | A par|
|00000b90| 61 74 68 79 72 6f 69 64 | 20 68 6f 72 6d 6f 6e 65 |athyroid| hormone|
|00000ba0| 2d 72 65 6c 61 74 65 64 | 20 70 72 6f 74 65 69 6e |-related| protein|
|00000bb0| 20 28 50 54 48 52 50 29 | 20 69 73 20 6f 66 74 65 | (PTHRP)| is ofte|
|00000bc0| 6e 20 73 65 63 72 65 74 | 65 64 20 62 79 20 74 75 |n secret|ed by tu|
|00000bd0| 6d 6f 72 73 0d 0a 69 6e | 20 70 61 74 69 65 6e 74 |mors..in| patient|
|00000be0| 73 20 77 69 74 68 20 68 | 75 6d 6f 72 61 6c 20 68 |s with h|umoral h|
|00000bf0| 79 70 65 72 63 61 6c 63 | 65 6d 69 61 20 6f 66 20 |ypercalc|emia of |
|00000c00| 63 61 6e 63 65 72 2e 20 | 20 42 65 63 61 75 73 65 |cancer. | Because|
|00000c10| 20 74 68 65 72 65 20 69 | 73 20 6c 69 74 74 6c 65 | there i|s little|
|00000c20| 0d 0a 69 6e 66 6f 72 6d | 61 74 69 6f 6e 20 61 76 |..inform|ation av|
|00000c30| 61 69 6c 61 62 6c 65 20 | 6f 6e 20 74 68 65 20 63 |ailable |on the c|
|00000c40| 69 72 63 75 6c 61 74 69 | 6e 67 20 66 6f 72 6d 73 |irculati|ng forms|
|00000c50| 20 61 6e 64 20 6c 65 76 | 65 6c 73 20 6f 66 20 74 | and lev|els of t|
|00000c60| 68 69 73 20 70 72 6f 74 | 65 69 6e 20 69 6e 0d 0a |his prot|ein in..|
|00000c70| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 68 75 |patients| with hu|
|00000c80| 6d 6f 72 61 6c 20 68 79 | 70 65 72 63 61 6c 63 65 |moral hy|percalce|
|00000c90| 6d 69 61 20 6f 66 20 63 | 61 6e 63 65 72 20 6f 72 |mia of c|ancer or|
|00000ca0| 20 6f 74 68 65 72 20 63 | 6f 6e 64 69 74 69 6f 6e | other c|ondition|
|00000cb0| 73 2c 20 32 0d 0a 73 65 | 6e 73 69 74 69 76 65 2c |s, 2..se|nsitive,|
|00000cc0| 20 72 65 67 69 6f 6e 2d | 73 70 65 63 69 66 69 63 | region-|specific|
|00000cd0| 20 69 6d 6d 75 6e 6f 61 | 73 73 61 79 73 20 66 6f | immunoa|ssays fo|
|00000ce0| 72 20 50 54 48 52 50 20 | 77 65 72 65 20 64 65 76 |r PTHRP |were dev|
|00000cf0| 65 6c 6f 70 65 64 2e 20 | 20 50 6c 61 73 6d 61 20 |eloped. | Plasma |
|00000d00| 66 72 6f 6d 0d 0a 36 30 | 20 6e 6f 72 6d 61 6c 20 |from..60| normal |
|00000d10| 70 65 72 73 6f 6e 73 2c | 20 33 30 20 70 61 74 69 |persons,| 30 pati|
|00000d20| 65 6e 74 73 20 77 69 74 | 68 20 68 75 6d 6f 72 61 |ents wit|h humora|
|00000d30| 6c 20 68 79 70 65 72 63 | 61 6c 63 65 6d 69 61 20 |l hyperc|alcemia |
|00000d40| 6f 66 20 63 61 6e 63 65 | 72 2c 20 61 6e 64 0d 0a |of cance|r, and..|
|00000d50| 70 61 74 69 65 6e 74 73 | 20 77 69 74 68 20 6f 74 |patients| with ot|
|00000d60| 68 65 72 20 63 6f 6e 64 | 69 74 69 6f 6e 73 20 28 |her cond|itions (|
|00000d70| 46 69 67 20 34 33 2d 32 | 29 20 77 61 73 20 74 65 |Fig 43-2|) was te|
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|00002890| 50 3b 20 57 6f 6f 64 73 | 6f 6e 20 47 43 20 49 49 |P; Woods|on GC II|
|000028a0| 49 3b 20 59 61 6e 6f 76 | 65 72 20 4d 4a 3b 20 4d |I; Yanov|er MJ; M|
|000028b0| 79 73 69 77 20 57 4a 3b | 20 4b 6f 68 73 65 20 4c |ysiw WJ;| Kohse L|
|000028c0| 3b 20 52 61 6f 20 4d 42 | 3b 20 53 74 65 69 67 65 |; Rao MB|; Steige|
|000028d0| 72 20 50 3b 0d 0a 52 69 | 63 68 6d 6f 6e 64 20 42 |r P;..Ri|chmond B|
|000028e0| 3b 20 43 68 65 73 6e 75 | 74 20 43 48 20 49 49 49 |; Chesnu|t CH III|
|000028f0| 0d 0a 28 45 6d 6f 72 79 | 20 55 6e 69 76 3b 20 55 |..(Emory| Univ; U|
|00002900| 6e 69 76 20 6f 66 20 43 | 61 6c 69 66 6f 72 6e 69 |niv of C|aliforni|
|00002910| 61 2c 20 53 61 6e 20 46 | 72 61 6e 63 69 73 63 6f |a, San F|rancisco|
|00002920| 3b 20 4b 75 61 6b 69 6e | 69 20 4d 65 64 20 43 74 |; Kuakin|i Med Ct|
|00002930| 72 2c 20 48 6f 6e 6f 6c | 75 6c 75 3b 0d 0a 55 6e |r, Honol|ulu;..Un|
|00002940| 69 76 20 6f 66 20 43 6f | 6c 6f 72 61 64 6f 3b 20 |iv of Co|lorado; |
|00002950| 4f 68 69 6f 20 53 74 61 | 74 65 20 55 6e 69 76 3b |Ohio Sta|te Univ;|
|00002960| 20 65 74 20 61 6c 29 20 | 4e 20 45 6e 67 6c 20 4a | et al) |N Engl J|
|00002970| 20 4d 65 64 20 33 32 33 | 3a 37 33 2d 37 39 2c 20 | Med 323|:73-79, |
|00002980| 31 39 39 30 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1990..--|--------|
|00002990| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029d0| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|000029e0| 0d 0a 0d 0a 20 20 20 20 | 20 50 6f 73 74 6d 65 6e |.... | Postmen|
|000029f0| 6f 70 61 75 73 61 6c 20 | 6f 73 74 65 6f 70 6f 72 |opausal |osteopor|
|00002a00| 6f 73 69 73 20 69 73 20 | 61 20 63 6f 6d 6d 6f 6e |osis is |a common|
|00002a10| 20 61 6e 64 20 63 6f 73 | 74 6c 79 20 64 69 73 6f | and cos|tly diso|
|00002a20| 72 64 65 72 2e 20 20 54 | 68 65 0d 0a 62 69 70 68 |rder. T|he..biph|
|00002a30| 6f 73 70 68 6f 6e 61 74 | 65 20 65 74 69 64 72 6f |osphonat|e etidro|
|00002a40| 6e 61 74 65 20 69 73 20 | 6f 6e 65 20 6f 66 20 74 |nate is |one of t|
|00002a50| 68 65 20 74 72 65 61 74 | 6d 65 6e 74 73 20 74 68 |he treat|ments th|
|00002a60| 61 74 20 68 61 76 65 20 | 62 65 65 6e 20 75 73 65 |at have |been use|
|00002a70| 64 20 66 6f 72 20 69 74 | 2c 0d 0a 62 75 74 20 6f |d for it|,..but o|
|00002a80| 6e 6c 79 20 69 6e 20 73 | 68 6f 72 74 2d 74 65 72 |nly in s|hort-ter|
|00002a90| 6d 2c 20 75 6e 63 6f 6e | 74 72 6f 6c 6c 65 64 20 |m, uncon|trolled |
|00002aa0| 74 72 69 61 6c 73 2e 20 | 20 41 20 70 6c 61 63 65 |trials. | A place|
|00002ab0| 62 6f 2d 63 6f 6e 74 72 | 6f 6c 6c 65 64 2c 0d 0a |bo-contr|olled,..|
|00002ac0| 72 61 6e 64 6f 6d 69 7a | 65 64 2c 20 64 6f 75 62 |randomiz|ed, doub|
|00002ad0| 6c 65 2d 62 6c 69 6e 64 | 20 74 72 69 61 6c 20 77 |le-blind| trial w|
|00002ae0| 61 73 20 75 6e 64 65 72 | 74 61 6b 65 6e 20 74 68 |as under|taken th|
|00002af0| 61 74 20 63 6f 6e 74 69 | 6e 75 65 64 20 66 6f 72 |at conti|nued for|
|00002b00| 20 32 20 79 65 61 72 73 | 2e 20 20 41 0d 0a 74 6f | 2 years|. A..to|
|00002b10| 74 61 6c 20 6f 66 20 34 | 32 39 20 77 6f 6d 65 6e |tal of 4|29 women|
|00002b20| 20 77 69 74 68 20 70 6f | 73 74 6d 65 6e 6f 70 61 | with po|stmenopa|
|00002b30| 75 73 61 6c 20 6f 73 74 | 65 6f 70 6f 72 6f 73 69 |usal ost|eoporosi|
|00002b40| 73 20 77 65 72 65 20 61 | 73 73 69 67 6e 65 64 20 |s were a|ssigned |
|00002b50| 74 6f 20 72 65 63 65 69 | 76 65 20 31 0d 0a 67 20 |to recei|ve 1..g |
|00002b60| 6f 66 20 70 68 6f 73 70 | 68 61 74 65 20 6f 72 20 |of phosp|hate or |
|00002b70| 70 6c 61 63 65 62 6f 20 | 66 6f 72 20 33 20 64 61 |placebo |for 3 da|
|00002b80| 79 73 2c 20 61 6e 64 20 | 34 30 30 20 6d 67 20 6f |ys, and |400 mg o|
|00002b90| 66 20 65 74 69 64 72 6f | 6e 61 74 65 20 6f 72 20 |f etidro|nate or |
|00002ba0| 70 6c 61 63 65 62 6f 0d | 0a 64 61 69 6c 79 20 66 |placebo.|.daily f|
|00002bb0| 6f 72 20 74 68 65 20 6e | 65 78 74 20 32 20 77 65 |or the n|ext 2 we|
|00002bc0| 65 6b 73 2e 20 20 54 68 | 65 79 20 74 68 65 6e 20 |eks. Th|ey then |
|00002bd0| 72 65 63 65 69 76 65 64 | 20 35 30 30 20 6d 67 20 |received| 500 mg |
|00002be0| 6f 66 20 63 61 6c 63 69 | 75 6d 20 64 61 69 6c 79 |of calci|um daily|
|00002bf0| 20 66 6f 72 20 37 34 0d | 0a 64 61 79 73 2e 20 20 | for 74.|.days. |
|00002c00| 45 69 67 68 74 20 63 79 | 63 6c 65 73 20 6f 66 20 |Eight cy|cles of |
|00002c10| 74 72 65 61 74 6d 65 6e | 74 20 77 65 72 65 20 67 |treatmen|t were g|
|00002c20| 69 76 65 6e 2e 20 20 42 | 6f 6e 65 20 6d 61 73 73 |iven. B|one mass|
|00002c30| 20 77 61 73 20 6d 65 61 | 73 75 72 65 64 20 62 79 | was mea|sured by|
|00002c40| 0d 0a 64 75 61 6c 2d 70 | 68 6f 74 6f 6e 20 61 62 |..dual-p|hoton ab|
|00002c50| 73 6f 72 70 74 69 6f 6d | 65 74 72 79 2e 0d 0a 20 |sorptiom|etry... |
|00002c60| 20 20 20 20 54 68 65 20 | 62 6f 6e 65 20 6d 69 6e | The |bone min|
|00002c70| 65 72 61 6c 20 64 65 6e | 73 69 74 79 20 6f 66 20 |eral den|sity of |
|00002c80| 74 68 65 20 6c 75 6d 62 | 61 72 20 73 70 69 6e 65 |the lumb|ar spine|
|00002c90| 20 69 6e 63 72 65 61 73 | 65 64 20 73 69 67 6e 69 | increas|ed signi|
|00002ca0| 66 69 63 61 6e 74 6c 79 | 20 69 6e 0d 0a 74 68 65 |ficantly| in..the|
|00002cb0| 20 65 74 69 64 72 6f 6e | 61 74 65 2d 74 72 65 61 | etidron|ate-trea|
|00002cc0| 74 65 64 20 70 61 74 69 | 65 6e 74 73 20 64 75 72 |ted pati|ents dur|
|00002cd0| 69 6e 67 20 74 68 65 20 | 32 2d 79 65 61 72 20 70 |ing the |2-year p|
|00002ce0| 65 72 69 6f 64 2e 20 20 | 54 68 65 20 63 68 61 6e |eriod. |The chan|
|00002cf0| 67 65 73 20 61 74 20 33 | 0d 0a 73 69 74 65 73 20 |ges at 3|..sites |
|00002d00| 69 6e 20 74 68 65 20 68 | 69 70 20 77 65 72 65 20 |in the h|ip were |
|00002d10| 6d 69 78 65 64 2c 20 61 | 6e 64 20 74 68 65 20 62 |mixed, a|nd the b|
|00002d20| 6f 6e 65 20 6d 69 6e 65 | 72 61 6c 20 64 65 6e 73 |one mine|ral dens|
|00002d30| 69 74 79 20 6f 66 20 74 | 68 65 20 72 61 64 69 75 |ity of t|he radiu|
|00002d40| 73 20 64 69 64 0d 0a 6e | 6f 74 20 63 68 61 6e 67 |s did..n|ot chang|
|00002d50| 65 20 73 69 67 6e 69 66 | 69 63 61 6e 74 6c 79 2e |e signif|icantly.|
|00002d60| 20 20 46 65 77 65 72 20 | 65 74 69 64 72 6f 6e 61 | Fewer |etidrona|
|00002d70| 74 65 2d 74 72 65 61 74 | 65 64 20 70 61 74 69 65 |te-treat|ed patie|
|00002d80| 6e 74 73 20 68 61 64 20 | 6e 65 77 20 76 65 72 74 |nts had |new vert|
|00002d90| 65 62 72 61 6c 0d 0a 66 | 72 61 63 74 75 72 65 73 |ebral..f|ractures|
|00002da0| 2e 20 20 54 68 69 73 20 | 64 65 63 72 65 61 73 65 |. This |decrease|
|00002db0| 20 69 6e 20 66 72 61 63 | 74 75 72 65 73 20 77 61 | in frac|tures wa|
|00002dc0| 73 20 6d 6f 73 74 20 6d | 61 72 6b 65 64 20 69 6e |s most m|arked in|
|00002dd0| 20 74 68 65 20 77 6f 6d | 65 6e 20 77 68 6f 20 68 | the wom|en who h|
|00002de0| 61 64 0d 0a 74 68 65 20 | 6c 6f 77 65 73 74 20 73 |ad..the |lowest s|
|00002df0| 70 69 6e 61 6c 20 62 6f | 6e 65 20 6d 69 6e 65 72 |pinal bo|ne miner|
|00002e00| 61 6c 20 64 65 6e 73 69 | 74 79 20 62 65 66 6f 72 |al densi|ty befor|
|00002e10| 65 20 74 72 65 61 74 6d | 65 6e 74 2c 20 74 68 65 |e treatm|ent, the|
|00002e20| 20 72 61 74 65 73 20 62 | 65 69 6e 67 0d 0a 34 32 | rates b|eing..42|
|00002e30| 2e 33 2f 31 2c 30 30 30 | 20 70 61 74 69 65 6e 74 |.3/1,000| patient|
|00002e40| 2d 79 65 61 72 73 20 69 | 6e 20 74 68 65 20 65 74 |-years i|n the et|
|00002e50| 69 64 72 6f 6e 61 74 65 | 20 67 72 6f 75 70 20 61 |idronate| group a|
|00002e60| 6e 64 20 31 33 32 2e 37 | 2f 31 2c 30 30 30 20 70 |nd 132.7|/1,000 p|
|00002e70| 61 74 69 65 6e 74 2d 79 | 65 61 72 73 0d 0a 69 6e |atient-y|ears..in|
|00002e80| 20 74 68 65 20 70 6c 61 | 63 65 62 6f 20 67 72 6f | the pla|cebo gro|
|00002e90| 75 70 2e 20 20 54 68 65 | 20 72 65 73 75 6c 74 73 |up. The| results|
|00002ea0| 20 77 65 72 65 20 73 69 | 6d 69 6c 61 72 20 77 68 | were si|milar wh|
|00002eb0| 65 74 68 65 72 20 6f 72 | 20 6e 6f 74 20 70 68 6f |ether or| not pho|
|00002ec0| 73 70 68 61 74 65 20 77 | 61 73 0d 0a 67 69 76 65 |sphate w|as..give|
|00002ed0| 6e 2e 20 20 45 74 69 64 | 72 6f 6e 61 74 65 20 74 |n. Etid|ronate t|
|00002ee0| 68 65 72 61 70 79 20 72 | 65 64 75 63 65 64 20 74 |herapy r|educed t|
|00002ef0| 68 65 20 73 65 72 75 6d | 20 61 6c 6b 61 6c 69 6e |he serum| alkalin|
|00002f00| 65 20 70 68 6f 73 70 68 | 61 74 61 73 65 2c 20 62 |e phosph|atase, b|
|00002f10| 75 74 20 74 68 65 72 65 | 0d 0a 77 65 72 65 20 6e |ut there|..were n|
|00002f20| 6f 20 6f 74 68 65 72 20 | 63 6f 6e 73 69 73 74 65 |o other |consiste|
|00002f30| 6e 74 20 62 69 6f 63 68 | 65 6d 69 63 61 6c 20 63 |nt bioch|emical c|
|00002f40| 68 61 6e 67 65 73 2e 20 | 20 41 64 76 65 72 73 65 |hanges. | Adverse|
|00002f50| 20 64 72 75 67 20 65 66 | 66 65 63 74 73 20 77 65 | drug ef|fects we|
|00002f60| 72 65 20 6d 69 6c 64 0d | 0a 61 6e 64 20 69 6e 66 |re mild.|.and inf|
|00002f70| 72 65 71 75 65 6e 74 2e | 0d 0a 20 20 20 20 20 49 |requent.|.. I|
|00002f80| 6e 20 74 68 69 73 20 73 | 74 75 64 79 2c 20 63 79 |n this s|tudy, cy|
|00002f90| 63 6c 69 63 20 65 74 69 | 64 72 6f 6e 61 74 65 20 |clic eti|dronate |
|00002fa0| 74 68 65 72 61 70 79 20 | 70 72 6f 76 65 64 20 74 |therapy |proved t|
|00002fb0| 6f 20 62 65 20 61 6e 20 | 65 66 66 65 63 74 69 76 |o be an |effectiv|
|00002fc0| 65 0d 0a 74 72 65 61 74 | 6d 65 6e 74 20 66 6f 72 |e..treat|ment for|
|00002fd0| 20 70 6f 73 74 6d 65 6e | 6f 70 61 75 73 61 6c 20 | postmen|opausal |
|00002fe0| 6f 73 74 65 6f 70 6f 72 | 6f 73 69 73 2e 20 20 47 |osteopor|osis. G|
|00002ff0| 69 76 65 6e 20 66 6f 72 | 20 32 20 79 65 61 72 73 |iven for| 2 years|
|00003000| 2c 20 69 74 20 69 6e 63 | 72 65 61 73 65 64 0d 0a |, it inc|reased..|
|00003010| 73 70 69 6e 61 6c 20 62 | 6f 6e 65 20 64 65 6e 73 |spinal b|one dens|
|00003020| 69 74 79 2c 20 6c 6f 77 | 65 72 65 64 20 74 68 65 |ity, low|ered the|
|00003030| 20 72 61 74 65 20 6f 66 | 20 76 65 72 74 65 62 72 | rate of| vertebr|
|00003040| 61 6c 20 66 72 61 63 74 | 75 72 65 2c 20 61 6e 64 |al fract|ure, and|
|00003050| 20 63 61 75 73 65 64 20 | 66 65 77 0d 0a 73 65 72 | caused |few..ser|
|00003060| 69 6f 75 73 20 73 69 64 | 65 20 65 66 66 65 63 74 |ious sid|e effect|
|00003070| 73 2e 0d 0a 0d 0a 50 6f | 73 74 2d 43 6f 6d 6d 65 |s.....Po|st-Comme|
|00003080| 6e 74 0d 0a 0d 0a 20 20 | 20 20 20 4f 73 74 65 6f |nt.... | Osteo|
|00003090| 70 6f 72 6f 73 69 73 20 | 69 73 20 61 72 62 69 74 |porosis |is arbit|
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|000030b0| 73 20 62 6f 6e 65 20 64 | 65 6e 73 69 74 79 20 69 |s bone d|ensity i|
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|000030d0| 68 20 6f 72 0d 0a 74 77 | 65 6e 74 69 65 74 68 20 |h or..tw|entieth |
|000030e0| 70 65 72 63 65 6e 74 69 | 6c 65 20 66 6f 72 20 61 |percenti|le for a|
|000030f0| 67 65 2c 20 61 6e 64 20 | 69 74 20 69 73 20 69 6e |ge, and |it is in|
|00003100| 20 73 75 63 68 20 77 6f | 6d 65 6e 20 74 68 61 74 | such wo|men that|
|00003110| 20 6d 6f 73 74 20 76 65 | 72 74 65 62 72 61 6c 0d | most ve|rtebral.|
|00003120| 0a 63 72 75 73 68 20 66 | 72 61 63 74 75 72 65 73 |.crush f|ractures|
|00003130| 20 6f 72 20 6f 74 68 65 | 72 20 66 72 61 63 74 75 | or othe|r fractu|
|00003140| 72 65 73 20 6f 63 63 75 | 72 2e 20 20 54 68 65 20 |res occu|r. The |
|00003150| 64 69 73 6f 72 64 65 72 | 20 69 73 20 61 20 68 65 |disorder| is a he|
|00003160| 74 65 72 6f 67 65 6e 65 | 6f 75 73 0d 0a 6f 6e 65 |terogene|ous..one|
|00003170| 2c 20 62 75 74 20 74 68 | 65 20 66 75 6e 64 61 6d |, but th|e fundam|
|00003180| 65 6e 74 61 6c 20 70 72 | 6f 62 6c 65 6d 20 69 73 |ental pr|oblem is|
|00003190| 20 74 68 61 74 20 74 68 | 65 72 65 20 69 73 20 74 | that th|ere is t|
|000031a0| 6f 6f 20 6c 69 74 74 6c | 65 20 62 6f 6e 65 2e 20 |oo littl|e bone. |
|000031b0| 20 44 75 72 69 6e 67 20 | 74 68 65 0d 0a 65 61 72 | During |the..ear|
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|00003220| 61 64 65 71 75 61 74 65 | 20 63 6f 6d 70 65 6e 73 |adequate| compens|
|00003230| 61 74 69 6f 6e 20 69 6e | 20 74 68 65 20 66 6f 72 |ation in| the for|
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|00003270| 69 6e 69 73 68 65 64 20 | 62 6f 6e 65 20 66 6f 72 |inished |bone for|
|00003280| 6d 61 74 69 6f 6e 20 69 | 73 20 6d 6f 72 65 20 70 |mation i|s more p|
|00003290| 72 6f 6d 69 6e 65 6e 74 | 20 28 31 29 2e 0d 0a 20 |rominent| (1)... |
|000032a0| 20 20 20 20 4d 6f 73 74 | 20 74 72 65 61 74 6d 65 | Most| treatme|
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|000032c0| 6f 73 69 73 2c 20 69 6e | 63 6c 75 64 69 6e 67 20 |osis, in|cluding |
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|000032f0| 74 69 6f 6e 2e 20 20 41 | 6d 6f 6e 67 20 74 68 65 |tion. A|mong the|
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|000033e0| 20 69 73 20 6e 6f 74 20 | 73 6f 20 73 61 66 65 2e | is not |so safe.|
|000033f0| 20 20 43 61 6c 63 69 74 | 6f 6e 69 6e 20 69 73 20 | Calcit|onin is |
|00003400| 65 66 66 65 63 74 69 76 | 65 20 62 75 74 20 6d 75 |effectiv|e but mu|
|00003410| 73 74 20 62 65 0d 0a 69 | 6e 6a 65 63 74 65 64 20 |st be..i|njected |
|00003420| 28 61 6e 20 69 6e 74 72 | 61 6e 61 73 61 6c 20 70 |(an intr|anasal p|
|00003430| 72 65 70 61 72 61 74 69 | 6f 6e 20 6d 61 79 20 62 |reparati|on may b|
|00003440| 65 63 6f 6d 65 20 61 76 | 61 69 6c 61 62 6c 65 29 |ecome av|ailable)|
|00003450| 20 61 6e 64 20 69 73 20 | 76 65 72 79 0d 0a 65 78 | and is |very..ex|
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|00003470| 20 66 6c 75 6f 72 69 64 | 65 20 69 6e 63 72 65 61 | fluorid|e increa|
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|000034c0| 72 65 20 72 61 74 65 20 | 61 6e 64 20 63 61 75 73 |re rate |and caus|
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|00003500| 57 61 74 74 73 20 61 6e | 64 20 63 6f 77 6f 72 6b |Watts an|d cowork|
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|00003530| 73 65 64 20 73 70 69 6e | 61 6c 20 62 6f 6e 65 20 |sed spin|al bone |
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|00003550| 20 61 6e 64 20 64 65 63 | 72 65 61 73 65 64 20 74 | and dec|reased t|
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|00003570| 20 76 65 72 74 65 62 72 | 61 6c 20 66 72 61 63 74 | vertebr|al fract|
|00003580| 75 72 65 73 20 69 6e 20 | 77 6f 6d 65 6e 20 77 69 |ures in |women wi|
|00003590| 74 68 0d 0a 70 6f 73 74 | 6d 65 6e 6f 70 61 75 73 |th..post|menopaus|
|000035a0| 61 6c 20 6f 73 74 65 6f | 70 6f 72 6f 73 69 73 2c |al osteo|porosis,|
|000035b0| 20 65 73 70 65 63 69 61 | 6c 6c 79 20 69 6e 20 74 | especia|lly in t|
|000035c0| 68 6f 73 65 20 77 68 6f | 20 68 61 64 20 6d 6f 72 |hose who| had mor|
|000035d0| 65 20 73 65 76 65 72 65 | 0d 0a 6f 73 74 65 6f 70 |e severe|..osteop|
|000035e0| 6f 72 6f 73 69 73 20 61 | 6e 64 20 74 68 65 72 65 |orosis a|nd there|
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|00003630| 65 6e 74 69 61 74 65 64 | 20 62 79 20 74 68 65 20 |entiated| by the |
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|00003db0| 64 6f 63 72 69 6e 6f 6c | 6f 67 79 20 61 6e 64 20 |docrinol|ogy and |
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|00003dd0| 61 70 74 65 72 20 34 33 | 20 2d 2d 20 54 68 65 20 |apter 43| -- The |
|00003de0| 50 61 72 61 74 68 79 72 | 6f 69 64 20 47 6c 61 6e |Parathyr|oid Glan|
|00003df0| 64 73 20 61 6e 64 20 42 | 6f 6e 65 0d 0a 0d 0a 2d |ds and B|one....-|
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|00003e10| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e20| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 0d 0a 45 |--------|-----..E|
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|00003f30| 29 0d 0a 4e 20 45 6e 67 | 6c 20 4a 20 4d 65 64 20 |)..N Eng|l J Med |
|00003f40| 33 32 32 3a 38 30 32 2d | 38 30 39 2c 20 31 39 39 |322:802-|809, 199|
|00003f50| 30 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |0..-----|--------|
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|00003f70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003f90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00004fa0| 65 20 31 33 3a 37 34 31 | 2d 37 34 37 2c 20 31 39 |e 13:741|-747, 19|
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|00004fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ee0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ef0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 49 6d 70 72 6f |--------|-..Impro|
|00005f00| 76 65 64 20 53 75 72 76 | 69 76 61 6c 20 69 6e 20 |ved Surv|ival in |
|00005f10| 50 61 74 69 65 6e 74 73 | 20 57 69 74 68 20 44 69 |Patients| With Di|
|00005f20| 61 62 65 74 69 63 20 4e | 65 70 68 72 6f 70 61 74 |abetic N|ephropat|
|00005f30| 68 79 0d 0a 0d 0a 4d 61 | 74 68 69 65 73 65 6e 20 |hy....Ma|thiesen |
|00005f40| 45 52 2c 20 42 6f 72 63 | 68 2d 4a 6f 68 6e 73 65 |ER, Borc|h-Johnse|
|00005f50| 6e 20 4b 2c 20 4a 65 6e | 73 65 6e 20 44 56 2c 20 |n K, Jen|sen DV, |
|00005f60| 44 65 63 6b 65 72 74 20 | 54 20 28 53 74 65 6e 6f |Deckert |T (Steno|
|00005f70| 20 4d 65 6d 20 48 6f 73 | 70 2e 20 47 65 6e 74 6f | Mem Hos|p. Gento|
|00005f80| 66 74 65 3b 0d 0a 48 76 | 69 64 6f 72 65 20 48 6f |fte;..Hv|idore Ho|
|00005f90| 73 70 2c 20 4b 6c 61 6d | 70 65 6e 62 6f 72 67 2c |sp, Klam|penborg,|
|00005fa0| 20 44 65 6e 6d 61 72 6b | 0d 0a 44 69 61 62 65 74 | Denmark|..Diabet|
|00005fb0| 6f 6c 6f 67 69 61 20 33 | 32 3a 38 38 34 2d 38 38 |ologia 3|2:884-88|
|00005fc0| 36 2c 20 31 39 38 39 0d | 0a 2d 2d 2d 2d 2d 2d 2d |6, 1989.|.-------|
|00005fd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005fe0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005ff0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006000| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006010| 2d 2d 2d 2d 2d 2d 2d 0d | 0a 0d 0a 41 62 73 74 72 |-------.|...Abstr|
|00006020| 61 63 74 0d 0a 0d 0a 20 | 20 20 20 20 54 79 70 65 |act.... | Type|
|00006030| 20 31 20 64 69 61 62 65 | 74 65 73 20 68 61 73 20 | 1 diabe|tes has |
|00006040| 61 20 68 69 67 68 20 6d | 6f 72 74 61 6c 69 74 79 |a high m|ortality|
|00006050| 2c 20 63 6f 6e 66 69 6e | 65 64 20 61 6c 6d 6f 73 |, confin|ed almos|
|00006060| 74 20 65 78 63 6c 75 73 | 69 76 65 6c 79 20 74 6f |t exclus|ively to|
|00006070| 0d 0a 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |..patien|ts with |
|00006080| 64 69 61 62 65 74 69 63 | 20 6e 65 70 68 72 6f 70 |diabetic| nephrop|
|00006090| 61 74 68 79 2e 20 20 44 | 69 61 62 65 74 69 63 20 |athy. D|iabetic |
|000060a0| 6e 65 70 68 72 6f 70 61 | 74 68 79 20 69 73 20 63 |nephropa|thy is c|
|000060b0| 68 61 72 61 63 74 65 72 | 69 7a 65 64 20 62 79 0d |haracter|ized by.|
|000060c0| 0a 70 65 72 73 69 73 74 | 65 6e 74 20 70 72 6f 74 |.persist|ent prot|
|000060d0| 65 69 6e 75 72 69 61 2c | 20 69 6e 63 72 65 61 73 |einuria,| increas|
|000060e0| 65 64 20 62 6c 6f 6f 64 | 20 70 72 65 73 73 75 72 |ed blood| pressur|
|000060f0| 65 2c 20 61 6e 64 20 61 | 20 64 65 63 6c 69 6e 65 |e, and a| decline|
|00006100| 20 69 6e 20 67 6c 6f 6d | 65 72 75 6c 61 72 0d 0a | in glom|erular..|
|00006110| 66 69 6c 74 72 61 74 69 | 6f 6e 20 72 61 74 65 2e |filtrati|on rate.|
|00006120| 20 20 41 6c 74 68 6f 75 | 67 68 20 75 72 65 6d 69 | Althou|gh uremi|
|00006130| 61 20 69 73 20 74 68 65 | 20 6d 61 69 6e 20 63 61 |a is the| main ca|
|00006140| 75 73 65 20 6f 66 20 64 | 65 61 74 68 2c 20 63 61 |use of d|eath, ca|
|00006150| 72 64 69 6f 76 61 73 63 | 75 6c 61 72 0d 0a 64 69 |rdiovasc|ular..di|
|00006160| 73 65 61 73 65 73 20 61 | 6c 73 6f 20 63 6f 6e 74 |seases a|lso cont|
|00006170| 72 69 62 75 74 65 20 73 | 69 67 6e 69 66 69 63 61 |ribute s|ignifica|
|00006180| 6e 74 6c 79 20 74 6f 20 | 74 68 65 20 68 69 67 68 |ntly to |the high|
|00006190| 20 6d 6f 72 74 61 6c 69 | 74 79 20 69 6e 20 74 68 | mortali|ty in th|
|000061a0| 65 73 65 0d 0a 70 61 74 | 69 65 6e 74 73 2e 20 20 |ese..pat|ients. |
|000061b0| 41 20 73 74 75 64 79 20 | 77 61 73 20 63 61 72 72 |A study |was carr|
|000061c0| 69 65 64 20 6f 75 74 20 | 74 6f 20 64 65 74 65 72 |ied out |to deter|
|000061d0| 6d 69 6e 65 20 74 68 65 | 20 69 6d 70 61 63 74 20 |mine the| impact |
|000061e0| 6f 66 20 65 61 72 6c 79 | 0d 0a 61 6e 74 69 68 79 |of early|..antihy|
|000061f0| 70 65 72 74 65 6e 73 69 | 76 65 20 74 72 65 61 74 |pertensi|ve treat|
|00006200| 6d 65 6e 74 20 6f 6e 20 | 6f 76 65 72 61 6c 6c 20 |ment on |overall |
|00006210| 73 75 72 76 69 76 61 6c | 20 69 6e 20 70 61 74 69 |survival| in pati|
|00006220| 65 6e 74 73 20 77 69 74 | 68 20 64 69 61 62 65 74 |ents wit|h diabet|
|00006230| 69 63 0d 0a 6e 65 70 68 | 72 6f 70 61 74 68 79 2e |ic..neph|ropathy.|
|00006240| 0d 0a 20 20 20 20 20 54 | 77 6f 20 63 6f 68 6f 72 |.. T|wo cohor|
|00006250| 74 73 20 6f 66 20 74 79 | 70 65 20 31 20 64 69 61 |ts of ty|pe 1 dia|
|00006260| 62 65 74 69 63 20 70 61 | 74 69 65 6e 74 73 20 77 |betic pa|tients w|
|00006270| 69 74 68 20 70 65 72 73 | 69 73 74 65 6e 74 20 70 |ith pers|istent p|
|00006280| 72 6f 74 65 69 6e 75 72 | 69 61 20 77 65 72 65 0d |roteinur|ia were.|
|00006290| 0a 73 74 75 64 69 65 64 | 2e 20 20 54 68 65 20 66 |.studied|. The f|
|000062a0| 69 72 73 74 20 67 72 6f | 75 70 20 63 6f 6e 73 69 |irst gro|up consi|
|000062b0| 73 74 65 64 20 6f 66 20 | 34 39 20 70 61 74 69 65 |sted of |49 patie|
|000062c0| 6e 74 73 20 66 69 72 73 | 74 20 73 65 65 6e 20 62 |nts firs|t seen b|
|000062d0| 65 74 77 65 65 6e 20 31 | 39 35 37 20 61 6e 64 0d |etween 1|957 and.|
|000062e0| 0a 31 39 37 33 2e 20 20 | 54 68 65 20 73 65 63 6f |.1973. |The seco|
|000062f0| 6e 64 20 67 72 6f 75 70 | 20 63 6f 6e 73 69 73 74 |nd group| consist|
|00006300| 65 64 20 6f 66 20 37 31 | 20 70 61 74 69 65 6e 74 |ed of 71| patient|
|00006310| 73 20 73 65 65 6e 20 69 | 6e 69 74 69 61 6c 6c 79 |s seen i|nitially|
|00006320| 20 62 65 74 77 65 65 6e | 20 31 39 37 39 0d 0a 61 | between| 1979..a|
|00006330| 6e 64 20 31 39 38 33 2e | 20 20 41 74 20 74 68 65 |nd 1983.| At the|
|00006340| 20 6f 6e 73 65 74 20 6f | 66 20 6e 65 70 68 72 6f | onset o|f nephro|
|00006350| 70 61 74 68 79 2c 20 64 | 65 66 69 6e 65 64 20 61 |pathy, d|efined a|
|00006360| 73 20 74 68 65 20 74 69 | 6d 65 20 70 72 6f 74 65 |s the ti|me prote|
|00006370| 69 6e 20 65 78 63 72 65 | 74 69 6f 6e 0d 0a 6f 66 |in excre|tion..of|
|00006380| 20 6d 6f 72 65 20 74 68 | 61 6e 20 2e 35 20 67 20 | more th|an .5 g |
|00006390| 64 61 69 6c 79 20 77 61 | 73 20 66 69 72 73 74 20 |daily wa|s first |
|000063a0| 6e 6f 74 65 64 2c 20 74 | 68 65 20 32 20 67 72 6f |noted, t|he 2 gro|
|000063b0| 75 70 73 20 77 65 72 65 | 20 73 69 6d 69 6c 61 72 |ups were| similar|
|000063c0| 20 69 6e 20 61 67 65 2c | 0d 0a 64 75 72 61 74 69 | in age,|..durati|
|000063d0| 6f 6e 20 6f 66 20 64 69 | 61 62 65 74 65 73 2c 20 |on of di|abetes, |
|000063e0| 62 6c 6f 6f 64 20 70 72 | 65 73 73 75 72 65 2c 20 |blood pr|essure, |
|000063f0| 70 72 6f 74 65 69 6e 75 | 72 69 61 2c 20 61 6e 64 |proteinu|ria, and|
+--------+-------------------------+-------------------------+--------+--------+
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