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|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 31 35 30 30 7d |que_ID{Y|RB01500}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 41 73 73 65 73 73 69 |..$Title|{Assessi|
|000005c0| 6e 67 20 44 75 72 61 74 | 69 6f 6e 20 6f 66 20 41 |ng Durat|ion of A|
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|000005e0| 45 66 66 65 63 74 73 20 | 57 69 74 68 20 57 68 6f |Effects |With Who|
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|00000650| 56 41 20 4d 65 64 20 43 | 74 72 2c 20 4c 6f 6e 67 |VA Med C|tr, Long|
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|000006a0| 20 4d 65 64 7d 0d 0a 24 | 56 6f 6c 75 6d 65 7b 31 | Med}..$|Volume{1|
|000006b0| 34 39 7d 0d 0a 24 50 61 | 67 65 7b 32 30 32 31 2d |49}..$Pa|ge{2021-|
|000006c0| 32 30 32 35 7d 0d 0a 24 | 44 61 74 65 7b 31 39 38 |2025}..$|Date{198|
|000006d0| 39 7d 0d 0a 24 59 42 56 | 6f 6c 7b 31 39 39 31 20 |9}..$YBV|ol{1991 |
|000006e0| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 46 61 6d |Year Boo|k of Fam|
|000006f0| 69 6c 79 20 50 72 61 63 | 74 69 63 65 7d 0d 0a 24 |ily Prac|tice}..$|
|00000700| 43 68 61 70 74 65 72 7b | 32 2d 31 34 7d 0d 0a 24 |Chapter{|2-14}..$|
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|00000730| 72 69 63 68 2c 20 47 72 | 65 65 6e 20 61 6e 64 20 |rich, Gr|een and |
|00000740| 53 63 68 65 72 67 65 72 | 7d 0d 0a 24 54 61 62 6c |Scherger|}..$Tabl|
|00000750| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|00000760| 72 7b 4c 2e 41 2e 20 47 | 72 65 65 6e 2c 20 4d 2e |r{L.A. G|reen, M.|
|00000770| 44 2e 7d 0d 0a 0d 0a 43 | 6f 70 79 72 69 67 68 74 |D.}....C|opyright|
|00000780| 20 28 43 29 20 59 65 61 | 72 20 42 6f 6f 6b 20 4d | (C) Yea|r Book M|
|00000790| 65 64 69 63 61 6c 20 50 | 75 62 6c 69 73 68 65 72 |edical P|ublisher|
|000007a0| 73 2c 20 49 6e 63 2e 20 | 31 39 39 31 0d 0a 0d 0a |s, Inc. |1991....|
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|000007c0| 66 20 46 61 6d 69 6c 79 | 20 50 72 61 63 74 69 63 |f Family| Practic|
|000007d0| 65 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 32 20 2d |e....Cha|pter 2 -|
|000007e0| 2d 20 48 65 6d 61 74 6f | 6c 6f 67 69 63 20 61 6e |- Hemato|logic an|
|000007f0| 64 20 43 69 72 63 75 6c | 61 74 6f 72 79 20 44 69 |d Circul|atory Di|
|00000800| 73 65 61 73 65 73 0d 0a | 0d 0a 48 79 70 65 72 74 |seases..|..Hypert|
|00000810| 65 6e 73 69 6f 6e 0d 0a | 0d 0a 2d 2d 2d 2d 2d 2d |ension..|..------|
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|00000860| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 41 73 73 65 73 73 |--------|..Assess|
|00000870| 69 6e 67 20 44 75 72 61 | 74 69 6f 6e 20 6f 66 20 |ing Dura|tion of |
|00000880| 41 6e 74 69 68 79 70 65 | 72 74 65 6e 73 69 76 65 |Antihype|rtensive|
|00000890| 20 45 66 66 65 63 74 73 | 20 57 69 74 68 20 57 68 | Effects| With Wh|
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|000008b0| 65 73 73 75 72 65 0d 0a | 4d 6f 6e 69 74 6f 72 69 |essure..|Monitori|
|000008c0| 6e 67 0d 0a 0d 0a 43 68 | 65 75 6e 67 20 44 47 3b |ng....Ch|eung DG;|
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|00000930| 4d 65 64 20 31 34 39 3a | 32 30 32 31 2d 32 30 32 |Med 149:|2021-202|
|00000940| 35 2c 20 31 39 38 39 0d | 0a 2d 2d 2d 2d 2d 2d 2d |5, 1989.|.-------|
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|00002940| 65 72 73 69 74 79 20 73 | 74 75 64 65 6e 74 73 20 |ersity s|tudents |
|00002950| 28 33 34 20 77 6f 6d 65 | 6e 20 61 6e 64 20 32 37 |(34 wome|n and 27|
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|00002970| 65 2c 20 31 39 0d 0a 79 | 65 61 72 73 29 20 77 65 |e, 19..y|ears) we|
|00002980| 72 65 20 72 61 6e 64 6f | 6d 6c 79 20 61 73 73 69 |re rando|mly assi|
|00002990| 67 6e 65 64 20 74 6f 20 | 72 65 63 65 69 76 65 20 |gned to |receive |
|000029a0| 31 20 6f 66 20 74 68 65 | 20 33 20 74 79 70 65 73 |1 of the| 3 types|
|000029b0| 20 6f 66 20 62 6c 6f 6f | 64 20 70 72 65 73 73 75 | of bloo|d pressu|
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|000029d0| 67 69 76 65 6e 20 69 6e | 20 74 72 69 61 6c 20 31 |given in| trial 1|
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|00002a00| 74 68 61 74 20 69 6e 20 | 74 72 69 61 6c 20 31 2c |that in |trial 1,|
|00002a10| 0d 0a 65 78 63 65 70 74 | 20 74 68 61 74 20 74 68 |..except| that th|
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|00002ac0| 73 70 6f 6e 73 65 73 20 | 77 65 72 65 20 63 6f 6d |sponses |were com|
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|00002b00| 74 68 69 73 20 63 6f 6e | 63 65 72 6e 2e 0d 0a 20 |this con|cern... |
|00002b10| 20 20 20 20 4e 6f 20 64 | 69 66 66 65 72 65 6e 63 |    No d|ifferenc|
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|00002c40| 77 61 73 0d 0a 65 71 75 | 61 6c 6c 79 20 74 72 75 |was..equ|ally tru|
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|00002d70| 65 73 73 75 72 65 20 72 | 65 61 64 69 6e 67 73 20 |essure r|eadings |
|00002d80| 61 72 65 20 74 61 6b 65 | 6e 2e 20 20 54 68 65 20 |are take|n.  The |
|00002d90| 66 69 6e 64 69 6e 67 73 | 20 6f 66 20 74 68 65 73 |findings| of thes|
|00002da0| 65 20 32 20 74 72 69 61 | 6c 73 20 73 75 67 67 65 |e 2 tria|ls sugge|
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|00002dc0| 69 6f 6e 65 72 73 20 6e | 65 65 64 20 6e 6f 74 20 |ioners n|eed not |
|00002dd0| 62 65 20 63 6f 6e 63 65 | 72 6e 65 64 20 61 62 6f |be conce|rned abo|
|00002de0| 75 74 20 69 6e 66 6f 72 | 6d 69 6e 67 20 6e 6f 72 |ut infor|ming nor|
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|00002e10| 6e 73 69 76 65 20 70 61 | 74 69 65 6e 74 73 20 74 |nsive pa|tients t|
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|00002e50| 6d 6d 65 6e 74 0d 0a 0d | 0a 20 20 20 20 20 57 69 |mment...|.     Wi|
|00002e60| 74 68 68 6f 6c 64 69 6e | 67 20 69 6e 66 6f 72 6d |thholdin|g inform|
|00002e70| 61 74 69 6f 6e 20 66 72 | 6f 6d 20 70 61 74 69 65 |ation fr|om patie|
|00002e80| 6e 74 73 20 62 65 63 61 | 75 73 65 20 77 65 20 66 |nts beca|use we f|
|00002e90| 65 61 72 20 69 74 20 77 | 69 6c 6c 20 68 61 72 6d |ear it w|ill harm|
|00002ea0| 20 74 68 65 6d 0d 0a 72 | 61 69 73 65 73 20 63 68 | them..r|aises ch|
|00002eb0| 61 6c 6c 65 6e 67 69 6e | 67 20 63 75 6c 74 75 72 |allengin|g cultur|
|00002ec0| 61 6c 2c 20 63 6c 69 6e | 69 63 61 6c 2c 20 61 6e |al, clin|ical, an|
|00002ed0| 64 20 65 74 68 69 63 61 | 6c 20 69 73 73 75 65 73 |d ethica|l issues|
|00002ee0| 2e 20 20 54 68 69 73 20 | 66 61 73 63 69 6e 61 74 |.  This |fascinat|
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|00002f00| 73 75 72 65 73 20 75 73 | 20 74 68 61 74 2c 20 69 |sures us| that, i|
|00002f10| 6e 20 67 65 6e 65 72 61 | 6c 2c 20 77 65 20 63 61 |n genera|l, we ca|
|00002f20| 6e 20 74 65 6c 6c 20 6f | 75 72 20 70 61 74 69 65 |n tell o|ur patie|
|00002f30| 6e 74 73 20 74 68 65 20 | 74 72 75 74 68 20 61 62 |nts the |truth ab|
|00002f40| 6f 75 74 0d 0a 74 68 65 | 69 72 20 62 6c 6f 6f 64 |out..the|ir blood|
|00002f50| 20 70 72 65 73 73 75 72 | 65 20 77 69 74 68 6f 75 | pressur|e withou|
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|00002f70| 6e 66 6f 72 6d 61 74 69 | 6f 6e 20 6c 65 61 64 69 |nformati|on leadi|
|00002f80| 6e 67 20 74 6f 20 69 6e | 63 72 65 61 73 65 64 0d |ng to in|creased.|
|00002f90| 0a 62 6c 6f 6f 64 20 70 | 72 65 73 73 75 72 65 20 |.blood p|ressure |
|00002fa0| 61 6e 64 20 61 63 63 6f | 6d 70 61 6e 79 69 6e 67 |and acco|mpanying|
|00002fb0| 20 61 64 76 65 72 73 65 | 20 63 6f 6e 73 65 71 75 | adverse| consequ|
|00002fc0| 65 6e 63 65 73 2c 20 73 | 75 63 68 20 61 73 0d 0a |ences, s|uch as..|
|00002fd0| 6d 69 73 63 6c 61 73 73 | 69 66 69 63 61 74 69 6f |misclass|ificatio|
|00002fe0| 6e 2e 2d 2d 4c 2e 41 2e | 20 47 72 65 65 6e 2c 20 |n.--L.A.| Green, |
|00002ff0| 4d 2e 44 2e 0d 0a 24 55 | 6e 69 71 75 65 5f 49 44 |M.D...$U|nique_ID|
|00003000| 7b 59 52 42 30 31 35 30 | 33 7d 0d 0a 24 54 69 74 |{YRB0150|3}..$Tit|
|00003010| 6c 65 7b 55 73 65 20 6f | 66 20 53 61 6c 74 20 53 |le{Use o|f Salt S|
|00003020| 75 62 73 74 69 74 75 74 | 65 73 20 69 6e 20 74 68 |ubstitut|es in th|
|00003030| 65 20 54 72 65 61 74 6d | 65 6e 74 20 6f 66 20 44 |e Treatm|ent of D|
|00003040| 69 75 72 65 74 69 63 2d | 49 6e 64 75 63 65 64 0d |iuretic-|Induced.|
|00003050| 0a 48 79 70 6f 6b 61 6c | 65 6d 69 61 7d 0d 0a 24 |.Hypokal|emia}..$|
|00003060| 41 75 74 68 6f 72 7b 0d | 0a 48 75 65 73 74 6f 6e |Author{.|.Hueston|
|00003070| 2c 20 57 4a 7d 0d 0a 24 | 41 66 66 69 6c 69 61 74 |, WJ}..$|Affiliat|
|00003080| 69 6f 6e 7b 4d 65 6e 69 | 66 65 65 20 4d 65 64 20 |ion{Meni|fee Med |
|00003090| 43 74 72 2c 20 46 72 65 | 6e 63 68 62 75 72 67 2c |Ctr, Fre|nchburg,|
|000030a0| 20 4b 79 7d 0d 0a 24 4a | 6f 75 72 6e 61 6c 7b 4a | Ky}..$J|ournal{J|
|000030b0| 20 46 61 6d 20 50 72 61 | 63 74 7d 0d 0a 24 56 6f | Fam Pra|ct}..$Vo|
|000030c0| 6c 75 6d 65 7b 32 39 7d | 0d 0a 24 50 61 67 65 7b |lume{29}|..$Page{|
|000030d0| 36 32 33 2d 36 32 36 7d | 0d 0a 24 44 61 74 65 7b |623-626}|..$Date{|
|000030e0| 31 39 38 39 7d 0d 0a 24 | 59 42 56 6f 6c 7b 31 39 |1989}..$|YBVol{19|
|000030f0| 39 31 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |91 Year |Book of |
|00003100| 46 61 6d 69 6c 79 20 50 | 72 61 63 74 69 63 65 7d |Family P|ractice}|
|00003110| 0d 0a 24 43 68 61 70 74 | 65 72 7b 32 2d 31 37 7d |..$Chapt|er{2-17}|
|00003120| 0d 0a 24 59 42 45 64 69 | 74 6f 72 7b 44 72 73 2e |..$YBEdi|tor{Drs.|
|00003130| 20 42 65 72 67 2c 20 42 | 6f 77 6d 61 6e 2c 20 44 | Berg, B|owman, D|
|00003140| 69 65 74 72 69 63 68 2c | 20 47 72 65 65 6e 20 61 |ietrich,| Green a|
|00003150| 6e 64 20 53 63 68 65 72 | 67 65 72 7d 0d 0a 24 54 |nd Scher|ger}..$T|
|00003160| 61 62 6c 65 7b 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |able{}..|$Comment|
|00003170| 61 74 6f 72 7b 41 2e 4f | 2e 20 42 65 72 67 2c 20 |ator{A.O|. Berg, |
|00003180| 4d 2e 44 2e 2c 20 4d 2e | 50 2e 48 2e 7d 0d 0a 0d |M.D., M.|P.H.}...|
|00003190| 0a 43 6f 70 79 72 69 67 | 68 74 20 28 43 29 20 59 |.Copyrig|ht (C) Y|
|000031a0| 65 61 72 20 42 6f 6f 6b | 20 4d 65 64 69 63 61 6c |ear Book| Medical|
|000031b0| 20 50 75 62 6c 69 73 68 | 65 72 73 2c 20 49 6e 63 | Publish|ers, Inc|
|000031c0| 2e 20 31 39 39 31 0d 0a | 0d 0a 31 39 39 31 20 59 |. 1991..|..1991 Y|
|000031d0| 65 61 72 20 42 6f 6f 6b | 20 6f 66 20 46 61 6d 69 |ear Book| of Fami|
|000031e0| 6c 79 20 50 72 61 63 74 | 69 63 65 0d 0a 0d 0a 43 |ly Pract|ice....C|
|000031f0| 68 61 70 74 65 72 20 32 | 20 2d 2d 20 48 65 6d 61 |hapter 2| -- Hema|
|00003200| 74 6f 6c 6f 67 69 63 20 | 61 6e 64 20 43 69 72 63 |tologic |and Circ|
|00003210| 75 6c 61 74 6f 72 79 20 | 44 69 73 65 61 73 65 73 |ulatory |Diseases|
|00003220| 0d 0a 0d 0a 48 79 70 65 | 72 74 65 6e 73 69 6f 6e |....Hype|rtension|
|00003230| 0d 0a 0d 0a 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |....----|--------|
|00003240| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003250| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003260| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003270| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003280| 2d 2d 0d 0a 55 73 65 20 | 6f 66 20 53 61 6c 74 20 |--..Use |of Salt |
|00003290| 53 75 62 73 74 69 74 75 | 74 65 73 20 69 6e 20 74 |Substitu|tes in t|
|000032a0| 68 65 20 54 72 65 61 74 | 6d 65 6e 74 20 6f 66 20 |he Treat|ment of |
|000032b0| 44 69 75 72 65 74 69 63 | 2d 49 6e 64 75 63 65 64 |Diuretic|-Induced|
|000032c0| 20 48 79 70 6f 6b 61 6c | 65 6d 69 61 0d 0a 0d 0a | Hypokal|emia....|
|000032d0| 48 75 65 73 74 6f 6e 20 | 57 4a 0d 0a 28 4d 65 6e |Hueston |WJ..(Men|
|000032e0| 69 66 65 65 20 4d 65 64 | 20 43 74 72 2c 20 46 72 |ifee Med| Ctr, Fr|
|000032f0| 65 6e 63 68 62 75 72 67 | 2c 20 4b 79 29 0d 0a 4a |enchburg|, Ky)..J|
|00003300| 20 46 61 6d 20 50 72 61 | 63 74 20 32 39 3a 36 32 | Fam Pra|ct 29:62|
|00003310| 33 2d 36 32 36 2c 20 31 | 39 38 39 0d 0a 2d 2d 2d |3-626, 1|989..---|
|00003320| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003330| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003340| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003350| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003360| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 0d 0a 0d 0a 41 |--------|---....A|
|00003370| 62 73 74 72 61 63 74 0d | 0a 0d 0a 20 20 20 20 20 |bstract.|...     |
|00003380| 48 79 70 6f 6b 61 6c 65 | 6d 69 61 20 69 73 20 61 |Hypokale|mia is a|
|00003390| 20 66 72 65 71 75 65 6e | 74 20 63 6f 6e 73 65 71 | frequen|t conseq|
|000033a0| 75 65 6e 63 65 20 6f 66 | 20 64 69 75 72 65 74 69 |uence of| diureti|
|000033b0| 63 20 74 72 65 61 74 6d | 65 6e 74 20 66 6f 72 0d |c treatm|ent for.|
|000033c0| 0a 68 79 70 65 72 74 65 | 6e 73 69 6f 6e 2e 20 20 |.hyperte|nsion.  |
|000033d0| 4e 65 61 72 6c 79 20 6f | 6e 65 20 74 68 69 72 64 |Nearly o|ne third|
|000033e0| 20 6f 66 20 61 6c 6c 20 | 70 61 74 69 65 6e 74 73 | of all |patients|
|000033f0| 20 67 69 76 65 6e 20 74 | 68 69 61 7a 69 64 65 20 | given t|hiazide |
|00003400| 64 69 75 72 65 74 69 63 | 73 20 77 69 6c 6c 0d 0a |diuretic|s will..|
|00003410| 68 61 76 65 20 73 6f 6d | 65 20 64 65 67 72 65 65 |have som|e degree|
|00003420| 20 6f 66 20 68 79 70 6f | 6b 61 6c 65 6d 69 61 2e | of hypo|kalemia.|
|00003430| 20 20 53 61 6c 74 20 73 | 75 62 73 74 69 74 75 74 |  Salt s|ubstitut|
|00003440| 65 73 20 70 72 6f 76 69 | 64 65 20 70 6f 74 61 73 |es provi|de potas|
|00003450| 73 69 75 6d 20 63 68 6c | 6f 72 69 64 65 0d 0a 61 |sium chl|oride..a|
|00003460| 74 20 61 20 63 6f 73 74 | 20 6f 6e 6c 79 20 38 25 |t a cost| only 8%|
|00003470| 20 74 6f 20 31 30 25 20 | 6f 66 20 74 68 61 74 20 | to 10% |of that |
|00003480| 6f 66 20 70 72 65 73 63 | 72 69 70 74 69 6f 6e 20 |of presc|ription |
|00003490| 70 6f 74 61 73 73 69 75 | 6d 20 61 67 65 6e 74 73 |potassiu|m agents|
|000034a0| 2e 20 20 54 68 65 20 76 | 61 6c 75 65 0d 0a 6f 66 |.  The v|alue..of|
|000034b0| 20 73 61 6c 74 20 73 75 | 62 73 74 69 74 75 74 65 | salt su|bstitute|
|000034c0| 73 20 66 6f 72 20 63 6f | 6e 74 72 6f 6c 6c 69 6e |s for co|ntrollin|
|000034d0| 67 20 64 69 75 72 65 74 | 69 63 69 6e 64 75 63 65 |g diuret|icinduce|
|000034e0| 64 20 68 79 70 6f 6b 61 | 6c 65 6d 69 61 20 77 61 |d hypoka|lemia wa|
|000034f0| 73 20 65 78 61 6d 69 6e | 65 64 0d 0a 69 6e 20 31 |s examin|ed..in 1|
|00003500| 30 20 70 61 74 69 65 6e | 74 73 20 77 68 6f 20 72 |0 patien|ts who r|
|00003510| 65 63 65 69 76 65 64 20 | 64 69 75 72 65 74 69 63 |eceived |diuretic|
|00003520| 20 74 68 65 72 61 70 79 | 20 66 6f 72 20 68 79 70 | therapy| for hyp|
|00003530| 65 72 74 65 6e 73 69 6f | 6e 20 61 6e 64 20 77 65 |ertensio|n and we|
|00003540| 72 65 20 75 73 69 6e 67 | 20 61 0d 0a 70 72 65 73 |re using| a..pres|
|00003550| 63 72 69 70 74 69 6f 6e | 20 72 65 70 6c 61 63 65 |cription| replace|
|00003560| 6d 65 6e 74 20 70 72 6f | 64 75 63 74 20 66 6f 72 |ment pro|duct for|
|00003570| 20 69 6e 64 75 63 65 64 | 20 68 79 70 6f 6b 61 6c | induced| hypokal|
|00003580| 65 6d 69 61 2e 0d 0a 20 | 20 20 20 20 54 68 65 20 |emia... |    The |
|00003590| 73 61 6c 74 20 73 75 62 | 73 74 69 74 75 74 65 2c |salt sub|stitute,|
|000035a0| 20 67 69 76 65 6e 20 66 | 6f 72 20 36 20 77 65 65 | given f|or 6 wee|
|000035b0| 6b 73 2c 20 77 61 73 20 | 65 66 66 65 63 74 69 76 |ks, was |effectiv|
|000035c0| 65 20 69 6e 20 6d 61 69 | 6e 74 61 69 6e 69 6e 67 |e in mai|ntaining|
|000035d0| 0d 0a 73 65 72 75 6d 20 | 70 6f 74 61 73 73 69 75 |..serum |potassiu|
|000035e0| 6d 20 6c 65 76 65 6c 73 | 20 69 6e 20 74 68 65 20 |m levels| in the |
|000035f0| 6e 6f 72 6d 61 6c 20 72 | 61 6e 67 65 2e 20 20 4f |normal r|ange.  O|
|00003600| 6e 6c 79 20 33 20 70 61 | 74 69 65 6e 74 73 20 68 |nly 3 pa|tients h|
|00003610| 61 64 20 73 69 64 65 20 | 65 66 66 65 63 74 73 2c |ad side |effects,|
|00003620| 0d 0a 61 6e 64 20 6e 6f | 6e 65 20 72 65 71 75 69 |..and no|ne requi|
|00003630| 72 65 64 20 64 69 73 63 | 6f 6e 74 69 6e 75 61 6e |red disc|ontinuan|
|00003640| 63 65 20 6f 66 20 74 68 | 65 20 70 72 6f 64 75 63 |ce of th|e produc|
|00003650| 74 2e 20 20 54 68 65 20 | 70 61 74 69 65 6e 74 73 |t.  The |patients|
|00003660| 2c 20 68 6f 77 65 76 65 | 72 2c 20 64 69 64 0d 0a |, howeve|r, did..|
|00003670| 6e 6f 74 20 63 61 72 65 | 20 66 6f 72 20 74 68 65 |not care| for the|
|00003680| 20 73 61 6c 74 20 73 75 | 62 73 74 69 74 75 74 65 | salt su|bstitute|
|00003690| 2c 20 61 6e 64 20 38 20 | 6f 70 74 65 64 20 74 6f |, and 8 |opted to|
|000036a0| 20 72 65 74 75 72 6e 20 | 74 6f 20 74 68 65 20 70 | return |to the p|
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|00003cc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003cd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ce0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003cf0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00003de0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003df0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003e00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
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|00005f00| 44 72 73 2e 20 42 65 72 | 67 2c 20 42 6f 77 6d 61 |Drs. Ber|g, Bowma|
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|00005f20| 65 6e 20 61 6e 64 20 53 | 63 68 65 72 67 65 72 7d |en and S|cherger}|
|00005f30| 0d 0a 24 54 61 62 6c 65 | 7b 7d 0d 0a 24 43 6f 6d |..$Table|{}..$Com|
|00005f40| 6d 65 6e 74 61 74 6f 72 | 7b 4c 2e 41 2e 20 47 72 |mentator|{L.A. Gr|
|00005f50| 65 65 6e 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |een, M.D|.}....Co|
|00005f60| 70 79 72 69 67 68 74 20 | 28 43 29 20 59 65 61 72 |pyright |(C) Year|
|00005f70| 20 42 6f 6f 6b 20 4d 65 | 64 69 63 61 6c 20 50 75 | Book Me|dical Pu|
|00005f80| 62 6c 69 73 68 65 72 73 | 2c 20 49 6e 63 2e 20 31 |blishers|, Inc. 1|
|00005f90| 39 39 31 0d 0a 0d 0a 31 | 39 39 31 20 59 65 61 72 |991....1|991 Year|
|00005fa0| 20 42 6f 6f 6b 20 6f 66 | 20 46 61 6d 69 6c 79 20 | Book of| Family |
|00005fb0| 50 72 61 63 74 69 63 65 | 0d 0a 0d 0a 43 68 61 70 |Practice|....Chap|
|00005fc0| 74 65 72 20 32 20 2d 2d | 20 48 65 6d 61 74 6f 6c |ter 2 --| Hematol|
|00005fd0| 6f 67 69 63 20 61 6e 64 | 20 43 69 72 63 75 6c 61 |ogic and| Circula|
|00005fe0| 74 6f 72 79 20 44 69 73 | 65 61 73 65 73 0d 0a 0d |tory Dis|eases...|
|00005ff0| 0a 41 6e 67 69 6e 61 20 | 61 6e 64 20 4d 79 6f 63 |.Angina |and Myoc|
|00006000| 61 72 64 69 61 6c 20 49 | 6e 66 61 72 63 74 69 6f |ardial I|nfarctio|
|00006010| 6e 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |n....---|--------|
|00006020| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006030| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006040| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006050| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006060| 2d 2d 2d 0d 0a 41 66 74 | 65 72 20 43 6f 72 6f 6e |---..Aft|er Coron|
|00006070| 61 72 79 20 54 68 72 6f | 6d 62 6f 6c 79 73 69 73 |ary Thro|mbolysis|
|00006080| 20 61 6e 64 20 52 65 70 | 65 72 66 75 73 69 6f 6e | and Rep|erfusion|
|00006090| 2c 20 57 68 61 74 20 4e | 65 78 74 3f 0d 0a 0d 0a |, What N|ext?....|
|000060a0| 42 61 6e 67 20 4e 55 3b | 20 57 69 6c 68 65 6c 6d |Bang NU;| Wilhelm|
|000060b0| 20 4f 47 3b 20 43 6c 61 | 79 6d 61 6e 20 4d 44 0d | OG; Cla|yman MD.|
|000060c0| 0a 28 4c 69 6c 6c 79 20 | 52 65 73 65 61 72 63 68 |.(Lilly |Research|
|000060d0| 20 4c 61 62 2c 20 49 6e | 64 69 61 6e 61 70 6f 6c | Lab, In|dianapol|
|000060e0| 69 73 3b 20 49 6e 64 69 | 61 6e 61 20 55 6e 69 76 |is; Indi|ana Univ|
|000060f0| 2c 20 49 6e 64 69 61 6e | 61 70 6f 6c 69 73 29 0d |, Indian|apolis).|
|00006100| 0a 4a 20 41 6d 20 43 6f | 6c 6c 20 43 61 72 64 69 |.J Am Co|ll Cardi|
|00006110| 6f 6c 20 31 34 3a 38 33 | 37 2d 38 34 39 2c 20 31 |ol 14:83|7-849, 1|
|00006120| 39 38 39 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |989..---|--------|
|00006130| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006140| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006150| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00006170| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00006180| 0a 0d 0a 20 20 20 20 20 | 54 68 69 72 74 79 20 79 |...     |Thirty y|
|00006190| 65 61 72 73 20 6f 66 20 | 63 6c 69 6e 69 63 61 6c |ears of |clinical|
|000061a0| 20 74 72 69 61 6c 73 20 | 6f 66 20 74 68 72 6f 6d | trials |of throm|
|000061b0| 62 6f 6c 79 73 69 73 20 | 66 6f 72 20 61 63 75 74 |bolysis |for acut|
|000061c0| 65 20 6d 79 6f 63 61 72 | 64 69 61 6c 0d 0a 69 6e |e myocar|dial..in|
|000061d0| 66 61 72 63 74 69 6f 6e | 20 68 61 76 65 20 73 68 |farction| have sh|
|000061e0| 6f 77 6e 20 74 68 61 74 | 20 74 72 65 61 74 6d 65 |own that| treatme|
|000061f0| 6e 74 20 77 69 74 68 20 | 73 74 72 65 70 74 6f 6b |nt with |streptok|
|00006200| 69 6e 61 73 65 20 61 6e | 64 20 72 65 63 6f 6d 62 |inase an|d recomb|
|00006210| 69 6e 61 6e 74 0d 0a 74 | 69 73 73 75 65 2d 74 79 |inant..t|issue-ty|
|00006220| 70 65 20 70 6c 61 73 6d | 69 6e 6f 67 65 6e 20 61 |pe plasm|inogen a|
|00006230| 63 74 69 76 61 74 6f 72 | 20 28 72 74 2d 50 41 29 |ctivator| (rt-PA)|
|00006240| 20 72 65 73 75 6c 74 73 | 20 69 6e 20 72 65 70 65 | results| in repe|
|00006250| 72 66 75 73 69 6f 6e 20 | 6f 66 0d 0a 69 6e 66 61 |rfusion |of..infa|
|00006260| 72 63 74 2d 72 65 6c 61 | 74 65 64 20 61 72 74 65 |rct-rela|ted arte|
|00006270| 72 69 65 73 2c 20 73 61 | 6c 76 61 67 65 73 20 69 |ries, sa|lvages i|
|00006280| 73 63 68 65 6d 69 63 20 | 6d 79 6f 63 61 72 64 69 |schemic |myocardi|
|00006290| 75 6d 2c 20 69 6d 70 72 | 6f 76 65 73 20 6d 79 6f |um, impr|oves myo|
|000062a0| 63 61 72 64 69 61 6c 0d | 0a 70 65 72 66 6f 72 6d |cardial.|.perform|
|000062b0| 61 6e 63 65 2c 20 61 6e | 64 20 72 65 64 75 63 65 |ance, an|d reduce|
|000062c0| 73 20 6d 6f 72 74 61 6c | 69 74 79 2e 20 20 4e 65 |s mortal|ity.  Ne|
|000062d0| 76 65 72 74 68 65 6c 65 | 73 73 2c 20 74 68 65 20 |verthele|ss, the |
|000062e0| 69 6e 63 69 64 65 6e 63 | 65 20 6f 66 0d 0a 72 65 |incidenc|e of..re|
|000062f0| 70 65 72 66 75 73 69 6f | 6e 20 76 61 72 69 65 73 |perfusio|n varies|
|00006300| 20 77 69 64 65 6c 79 3b | 20 74 68 65 20 72 61 74 | widely;| the rat|
|00006310| 65 20 6f 66 20 72 65 6f | 63 63 6c 75 73 69 6f 6e |e of reo|cclusion|
|00006320| 20 69 73 20 68 69 67 68 | 2c 20 61 73 20 69 73 20 | is high|, as is |
|00006330| 74 68 65 0d 0a 69 6e 63 | 69 64 65 6e 63 65 20 6f |the..inc|idence o|
|00006340| 66 20 62 6c 65 65 64 69 | 6e 67 20 63 6f 6d 70 6c |f bleedi|ng compl|
|00006350| 69 63 61 74 69 6f 6e 73 | 2e 20 20 42 65 63 61 75 |ications|.  Becau|
|00006360| 73 65 20 6f 66 20 74 68 | 65 73 65 20 73 68 6f 72 |se of th|ese shor|
|00006370| 74 63 6f 6d 69 6e 67 73 | 2c 20 69 6d 70 72 6f 76 |tcomings|, improv|
|00006380| 65 64 0d 0a 74 68 72 6f | 6d 62 6f 6c 79 74 69 63 |ed..thro|mbolytic|
|00006390| 20 61 67 65 6e 74 73 20 | 61 6e 64 20 62 65 74 74 | agents |and bett|
|000063a0| 65 72 20 61 64 6a 75 6e | 63 74 69 76 65 20 74 68 |er adjun|ctive th|
|000063b0| 65 72 61 70 79 20 68 61 | 76 65 20 62 65 65 6e 20 |erapy ha|ve been |
|000063c0| 73 6f 75 67 68 74 2e 0d | 0a 20 20 20 20 20 49 6d |sought..|.     Im|
|000063d0| 70 72 6f 76 65 64 20 72 | 65 73 75 6c 74 73 20 6d |proved r|esults m|
|000063e0| 61 79 20 62 65 20 61 63 | 68 69 65 76 65 64 20 74 |ay be ac|hieved t|
|000063f0| 68 72 6f 75 67 68 20 63 | 68 61 6e 67 69 6e 67 20 |hrough c|hanging |
+--------+-------------------------+-------------------------+--------+--------+