home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-05 | 299.2 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000050| 00 00 00 01 a1 2e 00 00 | ee 0a 00 00 30 35 00 00 |........|....05..|
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|000000c0| 00 00 00 01 88 91 00 00 | 4b 0b 00 00 31 33 00 00 |........|K...13..|
|000000d0| 00 01 d3 9c 00 00 c2 0e | 00 00 31 34 00 00 00 01 |........|..14....|
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|00000470| 03 00 7a 0d 00 00 38 30 | 00 00 00 01 b3 b2 03 00 |..z...80|........|
|00000480| a1 0e 00 00 38 31 00 00 | 00 01 54 c1 03 00 76 0d |....81..|..T...v.|
|00000490| 00 00 38 32 00 00 00 01 | ca ce 03 00 89 09 00 00 |..82....|........|
|000004a0| 38 33 00 00 00 01 53 d8 | 03 00 93 09 00 00 38 34 |83....S.|......84|
|000004b0| 00 00 00 01 e6 e1 03 00 | 1d 08 00 00 38 35 00 00 |........|....85..|
|000004c0| 00 01 03 ea 03 00 1d 11 | 00 00 38 36 00 00 00 01 |........|..86....|
|000004d0| 20 fb 03 00 07 0b 00 00 | 38 37 00 00 00 01 27 06 | .......|87....'.|
|000004e0| 04 00 98 09 00 00 38 38 | 00 00 00 01 bf 0f 04 00 |......88|........|
|000004f0| 03 0b 00 00 38 39 00 00 | 00 01 c2 1a 04 00 e6 0d |....89..|........|
|00000500| 00 00 39 30 00 00 00 01 | a8 28 04 00 08 0a 00 00 |..90....|.(......|
|00000510| 39 31 00 00 00 01 b0 32 | 04 00 45 0a 00 00 39 32 |91.....2|..E...92|
|00000520| 00 00 00 01 f5 3c 04 00 | 62 12 00 00 39 33 00 00 |.....<..|b...93..|
|00000530| 00 01 57 4f 04 00 9d 0c | 00 00 39 34 00 00 00 01 |..WO....|..94....|
|00000540| f4 5b 04 00 ac 0c 00 00 | 39 35 00 00 00 01 a0 68 |.[......|95.....h|
|00000550| 04 00 f6 09 00 00 39 36 | 00 00 00 01 96 72 04 00 |......96|.....r..|
|00000560| d6 0c 00 00 39 37 00 00 | 00 01 6c 7f 04 00 52 10 |....97..|..l...R.|
|00000570| 00 00 39 38 00 00 00 01 | be 8f 04 00 af 0f 00 00 |..98....|........|
|00000580| 39 39 00 00 00 01 6d 9f | 04 00 62 0d 00 00 00 00 |99....m.|..b.....|
|00000590| 00 00 00 00 cf ac 04 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 31 30 30 30 7d |que_ID{Y|RB01000}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 52 6f 6c 65 20 6f 66 |..$Title|{Role of|
|000005c0| 20 41 64 6a 75 76 61 6e | 74 20 43 68 65 6d 6f 74 | Adjuvan|t Chemot|
|000005d0| 68 65 72 61 70 79 20 69 | 6e 20 4d 61 6c 65 20 42 |herapy i|n Male B|
|000005e0| 72 65 61 73 74 20 43 61 | 6e 63 65 72 7d 0d 0a 24 |reast Ca|ncer}..$|
|000005f0| 41 75 74 68 6f 72 7b 0d | 0a 50 61 74 65 6c 2c 20 |Author{.|.Patel, |
|00000600| 48 5a 2c 20 49 49 0d 0a | 42 75 7a 64 61 72 2c 20 |HZ, II..|Buzdar, |
|00000610| 41 55 0d 0a 48 6f 72 74 | 6f 62 61 67 79 69 2c 20 |AU..Hort|obagyi, |
|00000620| 47 4e 7d 0d 0a 24 41 66 | 66 69 6c 69 61 74 69 6f |GN}..$Af|filiatio|
|00000630| 6e 7b 55 6e 69 76 20 6f | 66 20 4d 44 20 41 6e 64 |n{Univ o|f MD And|
|00000640| 65 72 73 6f 6e 20 43 61 | 6e 63 65 72 20 43 74 72 |erson Ca|ncer Ctr|
|00000650| 2c 20 48 6f 75 73 74 6f | 6e 7d 0d 0a 24 4a 6f 75 |, Housto|n}..$Jou|
|00000660| 72 6e 61 6c 7b 43 61 6e | 63 65 72 7d 0d 0a 24 56 |rnal{Can|cer}..$V|
|00000670| 6f 6c 75 6d 65 7b 36 34 | 7d 0d 0a 24 50 61 67 65 |olume{64|}..$Page|
|00000680| 7b 31 35 38 33 2d 31 35 | 38 35 7d 0d 0a 24 44 61 |{1583-15|85}..$Da|
|00000690| 74 65 7b 31 39 38 39 7d | 0d 0a 24 59 42 56 6f 6c |te{1989}|..$YBVol|
|000006a0| 7b 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |{1991 Ye|ar Book |
|000006b0| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 7d |of Drug |Therapy}|
|000006c0| 0d 0a 24 43 68 61 70 74 | 65 72 7b 31 31 2d 31 34 |..$Chapt|er{11-14|
|000006d0| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|000006e0| 2e 20 4c 61 73 61 67 6e | 61 20 61 6e 64 20 57 65 |. Lasagn|a and We|
|000006f0| 69 6e 74 72 61 75 62 7d | 0d 0a 24 54 61 62 6c 65 |intraub}|..$Table|
|00000700| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|00000710| 7b 4c 2e 20 4c 61 73 61 | 67 6e 61 2c 20 4d 2e 44 |{L. Lasa|gna, M.D|
|00000720| 2e 7d 0d 0a 0d 0a 43 6f | 70 79 72 69 67 68 74 20 |.}....Co|pyright |
|00000730| 28 43 29 20 59 65 61 72 | 20 42 6f 6f 6b 20 4d 65 |(C) Year| Book Me|
|00000740| 64 69 63 61 6c 20 50 75 | 62 6c 69 73 68 65 72 73 |dical Pu|blishers|
|00000750| 2c 20 49 6e 63 2e 20 31 | 39 39 31 0d 0a 0d 0a 31 |, Inc. 1|991....1|
|00000760| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|00000770| 20 44 72 75 67 20 54 68 | 65 72 61 70 79 0d 0a 0d | Drug Th|erapy...|
|00000780| 0a 43 68 61 70 74 65 72 | 20 31 31 20 2d 2d 20 4e |.Chapter| 11 -- N|
|00000790| 65 6f 70 6c 61 73 74 69 | 63 20 44 69 73 65 61 73 |eoplasti|c Diseas|
|000007a0| 65 73 0d 0a 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |es....--|--------|
|000007b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007f0| 2d 2d 2d 2d 0d 0a 52 6f | 6c 65 20 6f 66 20 41 64 |----..Ro|le of Ad|
|00000800| 6a 75 76 61 6e 74 20 43 | 68 65 6d 6f 74 68 65 72 |juvant C|hemother|
|00000810| 61 70 79 20 69 6e 20 4d | 61 6c 65 20 42 72 65 61 |apy in M|ale Brea|
|00000820| 73 74 20 43 61 6e 63 65 | 72 0d 0a 0d 0a 50 61 74 |st Cance|r....Pat|
|00000830| 65 6c 20 48 5a 20 49 49 | 3b 20 42 75 7a 64 61 72 |el HZ II|; Buzdar|
|00000840| 20 41 55 3b 20 48 6f 72 | 74 6f 62 61 67 79 69 20 | AU; Hor|tobagyi |
|00000850| 47 4e 0d 0a 28 55 6e 69 | 76 20 6f 66 20 4d 44 20 |GN..(Uni|v of MD |
|00000860| 41 6e 64 65 72 73 6f 6e | 20 43 61 6e 63 65 72 20 |Anderson| Cancer |
|00000870| 43 74 72 2c 20 48 6f 75 | 73 74 6f 6e 29 0d 0a 43 |Ctr, Hou|ston)..C|
|00000880| 61 6e 63 65 72 20 36 34 | 3a 31 35 38 33 2d 31 35 |ancer 64|:1583-15|
|00000890| 38 35 2c 20 31 39 38 39 | 0d 0a 2d 2d 2d 2d 2d 2d |85, 1989|..------|
|000008a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000008e0| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 41 62 73 74 |--------|....Abst|
|000008f0| 72 61 63 74 0d 0a 0d 0a | 20 20 20 20 20 41 64 6a |ract....| Adj|
|00000900| 75 76 61 6e 74 20 63 68 | 65 6d 6f 74 68 65 72 61 |uvant ch|emothera|
|00000910| 70 79 20 72 65 64 75 63 | 65 73 20 74 68 65 20 6d |py reduc|es the m|
|00000920| 6f 72 74 61 6c 69 74 79 | 20 72 61 74 65 20 69 6e |ortality| rate in|
|00000930| 20 77 6f 6d 65 6e 20 77 | 69 74 68 20 62 72 65 61 | women w|ith brea|
|00000940| 73 74 0d 0a 63 61 6e 63 | 65 72 2c 20 62 75 74 20 |st..canc|er, but |
|00000950| 69 74 73 20 72 6f 6c 65 | 20 69 6e 20 6d 61 6c 65 |its role| in male|
|00000960| 20 62 72 65 61 73 74 20 | 63 61 6e 63 65 72 20 72 | breast |cancer r|
|00000970| 65 6d 61 69 6e 73 20 74 | 6f 20 62 65 20 64 65 66 |emains t|o be def|
|00000980| 69 6e 65 64 2e 20 20 41 | 66 74 65 72 20 6c 6f 63 |ined. A|fter loc|
|00000990| 61 6c 0d 0a 74 68 65 72 | 61 70 79 2c 20 31 31 20 |al..ther|apy, 11 |
|000009a0| 6d 61 6c 65 20 70 61 74 | 69 65 6e 74 73 20 77 69 |male pat|ients wi|
|000009b0| 74 68 20 6f 70 65 72 61 | 62 6c 65 20 73 74 61 67 |th opera|ble stag|
|000009c0| 65 20 49 49 20 28 37 29 | 20 6f 72 20 49 49 49 20 |e II (7)| or III |
|000009d0| 28 34 29 20 62 72 65 61 | 73 74 20 63 61 6e 63 65 |(4) brea|st cance|
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|000009f0| 77 69 74 68 20 61 64 6a | 75 76 61 6e 74 20 63 68 |with adj|uvant ch|
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|00000a30| 62 69 63 69 6e 2c 20 61 | 6e 64 20 63 79 63 6c 6f |bicin, a|nd cyclo|
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|00000a60| 79 63 6c 6f 70 68 6f 73 | 6f 70 68 61 6d 69 64 65 |yclophos|ophamide|
|00000a70| 2c 0d 0a 6d 65 74 68 6f | 74 72 65 78 61 74 65 2c |,..metho|trexate,|
|00000a80| 20 61 6e 64 20 35 2d 66 | 6c 75 6f 72 6f 75 72 61 | and 5-f|luoroura|
|00000a90| 63 69 6c 20 28 43 4d 46 | 29 20 69 6e 20 31 2e 20 |cil (CMF|) in 1. |
|00000aa0| 20 54 68 65 20 6d 65 64 | 69 61 6e 20 66 6f 6c 6c | The med|ian foll|
|00000ab0| 6f 77 2d 75 70 20 77 61 | 73 20 35 32 0d 0a 6d 6f |ow-up wa|s 52..mo|
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|00000ad0| 6f 20 31 33 35 20 6d 6f | 6e 74 68 73 29 2e 0d 0a |o 135 mo|nths)...|
|00000ae0| 20 20 20 20 20 53 65 76 | 65 6e 20 70 61 74 69 65 | Sev|en patie|
|00000af0| 6e 74 73 20 28 36 34 25 | 29 20 72 65 6d 61 69 6e |nts (64%|) remain|
|00000b00| 65 64 20 64 69 73 65 61 | 73 65 20 66 72 65 65 2e |ed disea|se free.|
|00000b10| 20 20 46 6f 75 72 20 70 | 61 74 69 65 6e 74 73 20 | Four p|atients |
|00000b20| 28 33 36 25 29 20 68 61 | 64 0d 0a 72 65 63 75 72 |(36%) ha|d..recur|
|00000b30| 72 65 6e 74 20 64 69 73 | 65 61 73 65 2c 20 69 6e |rent dis|ease, in|
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|00000b60| 20 64 69 73 65 61 73 65 | 2e 0d 0a 20 20 20 20 20 | disease|... |
|00000b70| 41 64 6a 75 76 61 6e 74 | 20 63 68 65 6d 6f 74 68 |Adjuvant| chemoth|
|00000b80| 65 72 61 70 79 20 73 68 | 6f 75 6c 64 20 62 65 20 |erapy sh|ould be |
|00000b90| 63 6f 6e 73 69 64 65 72 | 65 64 20 69 6e 20 6d 61 |consider|ed in ma|
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|00000bb0| 20 70 72 69 6d 61 72 79 | 0d 0a 62 72 65 61 73 74 | primary|..breast|
|00000bc0| 20 63 61 6e 63 65 72 2e | 20 20 54 77 6f 20 6f 74 | cancer.| Two ot|
|00000bd0| 68 65 72 20 70 72 65 76 | 69 6f 75 73 20 73 74 75 |her prev|ious stu|
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|00000bf0| 61 6e 64 20 74 61 6d 6f | 78 69 66 65 6e 2c 20 68 |and tamo|xifen, h|
|00000c00| 61 76 65 0d 0a 73 68 6f | 77 6e 20 74 68 61 74 20 |ave..sho|wn that |
|00000c10| 61 64 6a 75 76 61 6e 74 | 20 63 68 65 6d 6f 74 68 |adjuvant| chemoth|
|00000c20| 65 72 61 70 79 20 72 65 | 64 75 63 65 73 20 74 68 |erapy re|duces th|
|00000c30| 65 20 72 69 73 6b 20 6f | 66 20 72 65 63 75 72 72 |e risk o|f recurr|
|00000c40| 65 6e 63 65 20 61 6e 64 | 20 69 6d 70 72 6f 76 65 |ence and| improve|
|00000c50| 73 0d 0a 6f 76 65 72 61 | 6c 6c 20 73 75 72 76 69 |s..overa|ll survi|
|00000c60| 76 61 6c 20 69 6e 20 6d | 61 6c 65 20 70 61 74 69 |val in m|ale pati|
|00000c70| 65 6e 74 73 20 77 69 74 | 68 20 62 72 65 61 73 74 |ents wit|h breast|
|00000c80| 20 63 61 6e 63 65 72 2e | 0d 0a 0d 0a 50 6f 73 74 | cancer.|....Post|
|00000c90| 2d 43 6f 6d 6d 65 6e 74 | 0d 0a 0d 0a 20 20 20 20 |-Comment|.... |
|00000ca0| 20 43 61 6e 63 65 72 20 | 6f 66 20 74 68 65 20 62 | Cancer |of the b|
|00000cb0| 72 65 61 73 74 20 69 6e | 20 6d 61 6c 65 73 20 69 |reast in| males i|
|00000cc0| 73 20 61 20 72 61 72 65 | 20 64 69 73 65 61 73 65 |s a rare| disease|
|00000cd0| 2e 20 20 49 74 73 20 69 | 6e 63 69 64 65 6e 63 65 |. Its i|ncidence|
|00000ce0| 20 69 73 20 31 25 0d 0a | 74 68 61 74 20 6f 66 20 | is 1%..|that of |
|00000cf0| 62 72 65 61 73 74 20 63 | 61 6e 63 65 72 20 69 6e |breast c|ancer in|
|00000d00| 20 77 6f 6d 65 6e 2e 20 | 20 54 68 65 20 6e 61 74 | women. | The nat|
|00000d10| 75 72 61 6c 20 68 69 73 | 74 6f 72 79 20 6f 66 20 |ural his|tory of |
|00000d20| 74 68 65 20 64 69 73 65 | 61 73 65 20 73 65 65 6d |the dise|ase seem|
|00000d30| 73 20 74 6f 0d 0a 62 65 | 20 73 69 6d 69 6c 61 72 |s to..be| similar|
|00000d40| 20 69 6e 20 74 68 65 20 | 32 20 73 65 78 65 73 2e | in the |2 sexes.|
|00000d50| 0d 0a 20 20 20 20 20 54 | 68 65 20 72 61 72 69 74 |.. T|he rarit|
|00000d60| 79 20 6f 66 20 74 68 65 | 20 64 69 73 65 61 73 65 |y of the| disease|
|00000d70| 20 69 6e 20 6d 61 6c 65 | 73 20 6d 61 6b 65 73 20 | in male|s makes |
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|00002890| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|000028a0| 0a 0d 0a 41 62 73 74 72 | 61 63 74 0d 0a 0d 0a 20 |...Abstr|act.... |
|000028b0| 20 20 20 20 43 68 6c 6f | 72 61 6c 20 68 79 64 72 | Chlo|ral hydr|
|000028c0| 61 74 65 20 77 61 73 20 | 67 69 76 65 6e 20 69 6e |ate was |given in|
|000028d0| 74 72 61 72 65 63 74 61 | 6c 6c 79 20 74 6f 20 35 |trarecta|lly to 5|
|000028e0| 20 70 61 74 69 65 6e 74 | 73 20 69 6e 20 73 74 61 | patient|s in sta|
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|00002900| 20 77 68 6f 20 68 61 64 | 20 66 61 69 6c 65 64 20 | who had| failed |
|00002910| 74 6f 20 72 65 73 70 6f | 6e 64 20 74 6f 20 63 6f |to respo|nd to co|
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|00002990| 6e 76 75 6c 73 69 76 65 | 20 6d 65 64 69 63 61 74 |nvulsive| medicat|
|000029a0| 69 6f 6e 20 62 65 66 6f | 72 65 20 61 64 6d 69 73 |ion befo|re admis|
|000029b0| 73 69 6f 6e 2e 20 20 43 | 68 6c 6f 72 61 6c 20 68 |sion. C|hloral h|
|000029c0| 79 64 72 61 74 65 2c 20 | 33 30 20 6d 67 2f 6b 67 |ydrate, |30 mg/kg|
|000029d0| 2c 20 77 61 73 0d 0a 67 | 69 76 65 6e 20 69 6e 74 |, was..g|iven int|
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|000029f0| 20 32 20 68 6f 75 72 73 | 2c 20 73 74 61 72 74 69 | 2 hours|, starti|
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|00002a20| 66 0d 0a 6f 6e 73 65 74 | 20 6f 66 20 73 65 69 7a |f..onset| of seiz|
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|00002a40| 65 20 70 61 74 69 65 6e | 74 73 20 63 65 61 73 65 |e patien|ts cease|
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|00002aa0| 61 70 79 2c 20 61 6e 64 | 20 6e 6f 20 6e 65 77 20 |apy, and| no new |
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|00002ac0| 69 79 20 77 61 73 20 73 | 65 65 6e 20 6f 6e 0d 0a |iy was s|een on..|
|00002ad0| 65 6c 65 63 74 72 6f 65 | 6e 63 65 70 68 61 6c 6f |electroe|ncephalo|
|00002ae0| 67 72 61 70 68 69 63 20 | 73 74 75 64 79 2e 20 20 |graphic |study. |
|00002af0| 54 68 72 65 65 20 70 61 | 74 69 65 6e 74 73 20 72 |Three pa|tients r|
|00002b00| 65 67 61 69 6e 65 64 20 | 66 75 6c 6c 20 63 6f 6e |egained |full con|
|00002b10| 73 63 69 6f 75 73 6e 65 | 73 73 20 61 6e 64 0d 0a |sciousne|ss and..|
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|00002b50| 20 77 68 6f 20 68 61 64 | 20 68 61 64 20 72 65 63 | who had| had rec|
|00002b60| 75 72 72 65 6e 74 20 73 | 74 72 6f 6b 65 73 0d 0a |urrent s|trokes..|
|00002b70| 64 69 65 64 20 77 69 74 | 68 6f 75 74 20 6e 65 77 |died wit|hout new|
|00002b80| 20 73 65 69 7a 75 72 65 | 73 20 64 65 76 65 6c 6f | seizure|s develo|
|00002b90| 70 69 6e 67 2e 20 20 4f | 6e 65 20 70 61 74 69 65 |ping. O|ne patie|
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|00002bb0| 6e 0d 0a 63 6f 6e 73 63 | 69 6f 75 73 6e 65 73 73 |n..consc|iousness|
|00002bc0| 20 64 65 73 70 69 74 65 | 20 74 68 65 20 72 65 73 | despite| the res|
|00002bd0| 6f 6c 75 74 69 6f 6e 20 | 6f 66 20 65 70 69 6c 65 |olution |of epile|
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|00002bf0| 64 20 64 69 65 64 20 33 | 20 77 65 65 6b 73 0d 0a |d died 3| weeks..|
|00002c00| 61 66 74 65 72 20 61 64 | 6d 69 73 73 69 6f 6e 2e |after ad|mission.|
|00002c10| 20 20 41 75 74 6f 70 73 | 79 20 72 65 76 65 61 6c | Autops|y reveal|
|00002c20| 65 64 20 61 20 6d 61 73 | 73 69 76 65 20 68 65 6d |ed a mas|sive hem|
|00002c30| 6f 72 72 68 61 67 65 20 | 69 6e 20 74 68 65 20 72 |orrhage |in the r|
|00002c40| 69 67 68 74 20 74 65 6d | 70 6f 72 61 6c 0d 0a 6c |ight tem|poral..l|
|00002c50| 6f 62 65 2e 0d 0a 20 20 | 20 20 20 4e 6f 20 70 61 |obe... | No pa|
|00002c60| 74 69 65 6e 74 20 68 61 | 64 20 65 76 69 64 65 6e |tient ha|d eviden|
|00002c70| 63 65 20 6f 66 20 73 65 | 76 65 72 65 20 68 79 70 |ce of se|vere hyp|
|00002c80| 6f 78 65 6d 69 61 20 64 | 75 72 69 6e 67 20 73 74 |oxemia d|uring st|
|00002c90| 61 74 75 73 20 65 70 69 | 6c 65 70 74 69 63 75 73 |atus epi|lepticus|
|00002ca0| 2e 0d 0a 4e 6f 6e 65 20 | 68 61 64 20 68 65 6d 6f |...None |had hemo|
|00002cb0| 64 79 6e 61 6d 69 63 20 | 6f 72 20 72 65 73 70 69 |dynamic |or respi|
|00002cc0| 72 61 74 6f 72 79 20 73 | 69 64 65 20 65 66 66 65 |ratory s|ide effe|
|00002cd0| 63 74 73 20 66 72 6f 6d | 20 63 68 6c 6f 72 61 6c |cts from| chloral|
|00002ce0| 20 68 79 64 72 61 74 65 | 2e 0d 0a 0d 0a 50 6f 73 | hydrate|.....Pos|
|00002cf0| 74 2d 43 6f 6d 6d 65 6e | 74 0d 0a 0d 0a 20 20 20 |t-Commen|t.... |
|00002d00| 20 20 4f 6e 6c 79 20 61 | 20 66 65 77 20 72 65 70 | Only a| few rep|
|00002d10| 6f 72 74 73 20 68 61 76 | 65 20 64 65 61 6c 74 20 |orts hav|e dealt |
|00002d20| 77 69 74 68 20 74 68 65 | 20 75 73 65 20 6f 66 20 |with the| use of |
|00002d30| 63 68 6c 6f 72 61 6c 20 | 68 79 64 72 61 74 65 20 |chloral |hydrate |
|00002d40| 66 6f 72 0d 0a 74 72 65 | 61 74 6d 65 6e 74 20 6f |for..tre|atment o|
|00002d50| 66 20 73 74 61 74 75 73 | 20 65 70 69 6c 65 70 74 |f status| epilept|
|00002d60| 69 63 75 73 20 69 6e 20 | 65 69 74 68 65 72 20 61 |icus in |either a|
|00002d70| 64 75 6c 74 73 20 6f 72 | 20 63 68 69 6c 64 72 65 |dults or| childre|
|00002d80| 6e 2e 20 20 54 68 65 20 | 64 72 75 67 20 68 61 73 |n. The |drug has|
|00002d90| 2c 0d 0a 68 6f 77 65 76 | 65 72 2c 20 62 65 65 6e |,..howev|er, been|
|00002da0| 20 75 73 65 64 20 74 6f | 20 74 72 65 61 74 20 74 | used to| treat t|
|00002db0| 65 74 61 6e 75 73 2c 20 | 65 63 6c 61 6d 70 73 69 |etanus, |eclampsi|
|00002dc0| 61 2c 20 61 6e 64 20 6d | 79 6f 63 6c 6f 6e 69 63 |a, and m|yoclonic|
|00002dd0| 20 65 70 69 6c 65 70 73 | 79 2e 20 20 54 68 69 73 | epileps|y. This|
|00002de0| 0d 0a 73 74 75 64 79 20 | 73 75 67 67 65 73 74 73 |..study |suggests|
|00002df0| 20 74 68 61 74 20 69 66 | 20 73 74 61 6e 64 61 72 | that if| standar|
|00002e00| 64 20 74 72 65 61 74 6d | 65 6e 74 20 28 73 75 63 |d treatm|ent (suc|
|00002e10| 68 20 61 73 20 61 20 63 | 6f 6d 62 69 6e 61 74 69 |h as a c|ombinati|
|00002e20| 6f 6e 20 6f 66 20 64 69 | 61 7a 65 70 61 6d 0d 0a |on of di|azepam..|
|00002e30| 61 6e 64 20 70 68 65 6e | 79 74 6f 69 6e 29 20 66 |and phen|ytoin) f|
|00002e40| 61 69 6c 73 20 74 6f 20 | 73 74 6f 70 20 73 74 61 |ails to |stop sta|
|00002e50| 74 75 73 20 65 70 69 6c | 65 70 74 69 63 75 73 2c |tus epil|epticus,|
|00002e60| 20 6f 6e 65 20 73 68 6f | 75 6c 64 20 63 6f 6e 73 | one sho|uld cons|
|00002e70| 69 64 65 72 20 67 69 76 | 69 6e 67 0d 0a 63 68 6c |ider giv|ing..chl|
|00002e80| 6f 72 61 6c 20 68 79 64 | 72 61 74 65 2e 2d 2d 4c |oral hyd|rate.--L|
|00002e90| 2e 20 4c 61 73 61 67 6e | 61 2c 20 4d 2e 44 2e 0d |. Lasagn|a, M.D..|
|00002ea0| 0a 24 55 6e 69 71 75 65 | 5f 49 44 7b 59 52 42 30 |.$Unique|_ID{YRB0|
|00002eb0| 31 30 30 34 7d 0d 0a 24 | 54 69 74 6c 65 7b 50 68 |1004}..$|Title{Ph|
|00002ec0| 65 6e 6f 62 61 72 62 69 | 74 61 6c 20 66 6f 72 20 |enobarbi|tal for |
|00002ed0| 46 65 62 72 69 6c 65 20 | 53 65 69 7a 75 72 65 73 |Febrile |Seizures|
|00002ee0| 3a 20 20 45 66 66 65 63 | 74 73 20 6f 6e 20 49 6e |: Effec|ts on In|
|00002ef0| 74 65 6c 6c 69 67 65 6e | 63 65 20 61 6e 64 20 6f |telligen|ce and o|
|00002f00| 6e 0d 0a 53 65 69 7a 75 | 72 65 20 52 65 63 75 72 |n..Seizu|re Recur|
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|00002f20| 0d 0a 46 61 72 77 65 6c | 6c 2c 20 4a 52 0d 0a 4c |..Farwel|l, JR..L|
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|00002f40| 47 0d 0a 53 75 6c 7a 62 | 61 63 68 65 72 2c 20 53 |G..Sulzb|acher, S|
|00002f50| 49 0d 0a 45 6c 6c 65 6e | 62 65 72 67 2c 20 4a 48 |I..Ellen|berg, JH|
|00002f60| 0d 0a 4e 65 6c 73 6f 6e | 2c 20 4b 42 7d 0d 0a 24 |..Nelson|, KB}..$|
|00002f70| 41 66 66 69 6c 69 61 74 | 69 6f 6e 7b 55 6e 69 76 |Affiliat|ion{Univ|
|00002f80| 20 6f 66 20 57 61 73 68 | 69 6e 67 74 6f 6e 2c 20 | of Wash|ington, |
|00002f90| 53 65 61 74 74 6c 65 3b | 20 4e 61 74 6c 20 49 6e |Seattle;| Natl In|
|00002fa0| 73 74 20 6f 66 20 4e 65 | 75 72 6f 6c 6f 67 69 63 |st of Ne|urologic|
|00002fb0| 20 44 69 73 6f 72 64 65 | 72 73 0d 0a 61 6e 64 20 | Disorde|rs..and |
|00002fc0| 53 74 72 6f 6b 65 2c 20 | 42 65 74 68 65 73 64 61 |Stroke, |Bethesda|
|00002fd0| 2c 20 4d 64 7d 0d 0a 24 | 4a 6f 75 72 6e 61 6c 7b |, Md}..$|Journal{|
|00002fe0| 4e 20 45 6e 67 6c 20 4a | 20 4d 65 64 7d 0d 0a 24 |N Engl J| Med}..$|
|00002ff0| 56 6f 6c 75 6d 65 7b 33 | 32 32 7d 0d 0a 24 50 61 |Volume{3|22}..$Pa|
|00003000| 67 65 7b 33 36 34 2d 33 | 36 39 7d 0d 0a 24 44 61 |ge{364-3|69}..$Da|
|00003010| 74 65 7b 31 39 39 30 7d | 0d 0a 24 59 42 56 6f 6c |te{1990}|..$YBVol|
|00003020| 7b 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |{1991 Ye|ar Book |
|00003030| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 7d |of Drug |Therapy}|
|00003040| 0d 0a 24 43 68 61 70 74 | 65 72 7b 31 32 2d 32 7d |..$Chapt|er{12-2}|
|00003050| 0d 0a 24 59 42 45 64 69 | 74 6f 72 7b 44 72 73 2e |..$YBEdi|tor{Drs.|
|00003060| 20 4c 61 73 61 67 6e 61 | 20 61 6e 64 20 57 65 69 | Lasagna| and Wei|
|00003070| 6e 74 72 61 75 62 7d 0d | 0a 24 54 61 62 6c 65 7b |ntraub}.|.$Table{|
|00003080| 7d 0d 0a 24 43 6f 6d 6d | 65 6e 74 61 74 6f 72 7b |}..$Comm|entator{|
|00003090| 4c 2e 20 4c 61 73 61 67 | 6e 61 2c 20 4d 2e 44 2e |L. Lasag|na, M.D.|
|000030a0| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|000030b0| 43 29 20 59 65 61 72 20 | 42 6f 6f 6b 20 4d 65 64 |C) Year |Book Med|
|000030c0| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|000030d0| 20 49 6e 63 2e 20 31 39 | 39 31 0d 0a 0d 0a 31 39 | Inc. 19|91....19|
|000030e0| 39 31 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |91 Year |Book of |
|000030f0| 44 72 75 67 20 54 68 65 | 72 61 70 79 0d 0a 0d 0a |Drug The|rapy....|
|00003100| 43 68 61 70 74 65 72 20 | 31 32 20 2d 2d 20 4e 65 |Chapter |12 -- Ne|
|00003110| 75 72 6f 6c 6f 67 69 63 | 20 44 69 73 65 61 73 65 |urologic| Disease|
|00003120| 73 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |s....---|--------|
|00003130| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003140| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003150| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003170| 2d 2d 2d 0d 0a 50 68 65 | 6e 6f 62 61 72 62 69 74 |---..Phe|nobarbit|
|00003180| 61 6c 20 66 6f 72 20 46 | 65 62 72 69 6c 65 20 53 |al for F|ebrile S|
|00003190| 65 69 7a 75 72 65 73 3a | 20 20 45 66 66 65 63 74 |eizures:| Effect|
|000031a0| 73 20 6f 6e 20 49 6e 74 | 65 6c 6c 69 67 65 6e 63 |s on Int|elligenc|
|000031b0| 65 20 61 6e 64 20 6f 6e | 20 53 65 69 7a 75 72 65 |e and on| Seizure|
|000031c0| 0d 0a 52 65 63 75 72 72 | 65 6e 63 65 0d 0a 0d 0a |..Recurr|ence....|
|000031d0| 46 61 72 77 65 6c 6c 20 | 4a 52 3b 20 4c 65 65 20 |Farwell |JR; Lee |
|000031e0| 59 4a 3b 20 48 69 72 74 | 7a 20 44 47 3b 20 53 75 |YJ; Hirt|z DG; Su|
|000031f0| 6c 7a 62 61 63 68 65 72 | 20 53 49 3b 20 45 6c 6c |lzbacher| SI; Ell|
|00003200| 65 6e 62 65 72 67 20 4a | 48 3b 20 4e 65 6c 73 6f |enberg J|H; Nelso|
|00003210| 6e 20 4b 42 0d 0a 28 55 | 6e 69 76 20 6f 66 20 57 |n KB..(U|niv of W|
|00003220| 61 73 68 69 6e 67 74 6f | 6e 2c 20 53 65 61 74 74 |ashingto|n, Seatt|
|00003230| 6c 65 3b 20 4e 61 74 6c | 20 49 6e 73 74 20 6f 66 |le; Natl| Inst of|
|00003240| 20 4e 65 75 72 6f 6c 6f | 67 69 63 20 44 69 73 6f | Neurolo|gic Diso|
|00003250| 72 64 65 72 73 20 61 6e | 64 20 53 74 72 6f 6b 65 |rders an|d Stroke|
|00003260| 2c 0d 0a 42 65 74 68 65 | 73 64 61 2c 20 4d 64 29 |,..Bethe|sda, Md)|
|00003270| 20 4e 20 45 6e 67 6c 20 | 4a 20 4d 65 64 20 33 32 | N Engl |J Med 32|
|00003280| 32 3a 33 36 34 2d 33 36 | 39 2c 20 31 39 39 30 0d |2:364-36|9, 1990.|
|00003290| 0a 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |.-------|--------|
|000032a0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000032d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 0d |--------|-------.|
|000032e0| 0a 0d 0a 41 62 73 74 72 | 61 63 74 0d 0a 0d 0a 20 |...Abstr|act.... |
|000032f0| 20 20 20 20 50 68 65 6e | 6f 62 61 72 62 69 74 61 | Phen|obarbita|
|00003300| 6c 20 69 73 20 77 69 64 | 65 6c 79 20 75 73 65 64 |l is wid|ely used|
|00003310| 20 74 6f 20 74 72 65 61 | 74 20 63 68 69 6c 64 72 | to trea|t childr|
|00003320| 65 6e 20 68 61 76 69 6e | 67 20 66 65 62 72 69 6c |en havin|g febril|
|00003330| 65 20 73 65 69 7a 75 72 | 65 73 2c 0d 0a 62 75 74 |e seizur|es,..but|
|00003340| 20 74 68 65 72 65 20 69 | 73 20 63 6f 6e 63 65 72 | there i|s concer|
|00003350| 6e 20 6f 76 65 72 20 69 | 74 73 20 65 66 66 65 63 |n over i|ts effec|
|00003360| 74 73 20 6f 6e 20 63 6f | 67 6e 69 74 69 6f 6e 20 |ts on co|gnition |
|00003370| 61 6e 64 20 62 65 68 61 | 76 69 6f 72 2e 20 20 54 |and beha|vior. T|
|00003380| 68 65 20 73 69 64 65 0d | 0a 65 66 66 65 63 74 73 |he side.|.effects|
|00003390| 20 6f 66 20 70 68 65 6e | 6f 62 61 72 62 69 74 61 | of phen|obarbita|
|000033a0| 6c 20 77 65 72 65 20 65 | 78 61 6d 69 6e 65 64 20 |l were e|xamined |
|000033b0| 69 6e 20 32 31 37 20 63 | 68 69 6c 64 72 65 6e 20 |in 217 c|hildren |
|000033c0| 61 67 65 64 20 38 20 6d | 6f 6e 74 68 73 20 74 6f |aged 8 m|onths to|
|000033d0| 20 33 0d 0a 79 65 61 72 | 73 20 77 68 6f 20 68 61 | 3..year|s who ha|
|000033e0| 64 20 68 61 64 20 61 74 | 20 6c 65 61 73 74 20 31 |d had at| least 1|
|000033f0| 20 66 65 62 72 69 6c 65 | 20 73 65 69 7a 75 72 65 | febrile| seizure|
|00003400| 20 61 6e 64 20 77 65 72 | 65 20 61 74 20 72 69 73 | and wer|e at ris|
|00003410| 6b 20 6f 66 20 66 75 72 | 74 68 65 72 0d 0a 73 65 |k of fur|ther..se|
|00003420| 69 7a 75 72 65 73 2e 20 | 20 53 75 62 6a 65 63 74 |izures. | Subject|
|00003430| 73 20 77 65 72 65 20 72 | 61 6e 64 6f 6d 6c 79 20 |s were r|andomly |
|00003440| 61 73 73 69 67 6e 65 64 | 20 74 6f 20 70 68 65 6e |assigned| to phen|
|00003450| 6f 62 61 72 62 69 74 61 | 6c 2c 20 34 2d 35 20 6d |obarbita|l, 4-5 m|
|00003460| 67 2f 6b 67 2c 20 64 61 | 69 6c 79 2c 0d 0a 6f 72 |g/kg, da|ily,..or|
|00003470| 20 70 6c 61 63 65 62 6f | 2e 20 20 49 6e 74 65 6c | placebo|. Intel|
|00003480| 6c 69 67 65 6e 63 65 20 | 74 65 73 74 69 6e 67 20 |ligence |testing |
|00003490| 77 61 73 20 64 6f 6e 65 | 20 61 66 74 65 72 20 32 |was done| after 2|
|000034a0| 20 79 65 61 72 73 2e 0d | 0a 20 20 20 20 20 54 68 | years..|. Th|
|000034b0| 65 20 6d 65 61 6e 20 69 | 6e 74 65 6c 6c 69 67 65 |e mean i|ntellige|
|000034c0| 6e 63 65 20 71 75 6f 74 | 69 65 6e 74 20 77 61 73 |nce quot|ient was|
|000034d0| 20 38 20 70 6f 69 6e 74 | 73 20 6c 6f 77 65 72 20 | 8 point|s lower |
|000034e0| 69 6e 0d 0a 70 68 65 6e | 6f 62 61 72 62 69 74 61 |in..phen|obarbita|
|000034f0| 6c 2d 74 72 65 61 74 65 | 64 20 63 68 69 6c 64 72 |l-treate|d childr|
|00003500| 65 6e 20 74 68 61 6e 20 | 69 6e 20 70 6c 61 63 65 |en than |in place|
|00003510| 62 6f 20 72 65 63 69 70 | 69 65 6e 74 73 20 61 66 |bo recip|ients af|
|00003520| 74 65 72 20 32 20 79 65 | 61 72 73 2e 0d 0a 41 66 |ter 2 ye|ars...Af|
|00003530| 74 65 72 20 36 20 6d 6f | 6e 74 68 73 20 6d 6f 72 |ter 6 mo|nths mor|
|00003540| 65 2c 20 77 68 65 6e 20 | 6d 65 64 69 63 61 74 69 |e, when |medicati|
|00003550| 6f 6e 20 77 61 73 20 74 | 61 70 65 72 65 64 20 61 |on was t|apered a|
|00003560| 6e 64 20 73 74 6f 70 70 | 65 64 2c 20 74 68 65 20 |nd stopp|ed, the |
|00003570| 6d 65 61 6e 0d 0a 69 6e | 74 65 6c 6c 69 67 65 6e |mean..in|telligen|
|00003580| 63 65 20 71 75 6f 74 69 | 65 6e 74 20 77 61 73 20 |ce quoti|ent was |
|00003590| 35 20 70 6f 69 6e 74 73 | 20 6c 6f 77 65 72 20 69 |5 points| lower i|
|000035a0| 6e 20 74 68 65 20 73 74 | 75 64 79 20 73 75 62 6a |n the st|udy subj|
|000035b0| 65 63 74 73 2e 20 20 54 | 68 65 20 63 68 61 6e 63 |ects. T|he chanc|
|000035c0| 65 20 6f 66 0d 0a 72 65 | 6d 61 69 6e 69 6e 67 20 |e of..re|maining |
|000035d0| 66 72 65 65 20 6f 66 20 | 73 65 69 7a 75 72 65 20 |free of |seizure |
|000035e0| 64 69 64 20 6e 6f 74 20 | 64 69 66 66 65 72 20 73 |did not |differ s|
|000035f0| 69 67 6e 69 66 69 63 61 | 6e 74 6c 79 20 69 6e 20 |ignifica|ntly in |
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|000036f0| 73 20 6e 6f 20 73 69 67 | 6e 69 66 69 63 61 6e 74 |s no sig|nificant|
|00003700| 20 63 6f 75 6e 74 65 72 | 76 61 69 6c 69 6e 67 20 | counter|vailing |
|00003710| 62 65 6e 65 66 69 74 20 | 69 6e 0d 0a 70 72 65 76 |benefit |in..prev|
|00003720| 65 6e 74 69 6e 67 20 73 | 65 69 7a 75 72 65 73 2e |enting s|eizures.|
|00003730| 0d 0a 0d 0a 50 6f 73 74 | 2d 43 6f 6d 6d 65 6e 74 |....Post|-Comment|
|00003740| 0d 0a 0d 0a 20 20 20 20 | 20 49 66 20 70 68 65 6e |.... | If phen|
|00003750| 6f 62 61 72 62 69 74 61 | 6c 20 64 6f 65 73 6e 27 |obarbita|l doesn'|
|00003760| 74 20 70 72 65 76 65 6e | 74 20 66 65 62 72 69 6c |t preven|t febril|
|00003770| 65 20 73 65 69 7a 75 72 | 65 73 20 69 6e 20 63 68 |e seizur|es in ch|
|00003780| 69 6c 64 72 65 6e 2c 20 | 69 74 20 73 68 6f 75 6c |ildren, |it shoul|
|00003790| 64 0d 0a 6e 6f 74 20 62 | 65 20 67 69 76 65 6e 20 |d..not b|e given |
|000037a0| 72 65 67 61 72 64 6c 65 | 73 73 20 6f 66 20 77 68 |regardle|ss of wh|
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|000037c0| 73 20 61 64 76 65 72 73 | 65 20 65 66 66 65 63 74 |s advers|e effect|
|000037d0| 73 2e 20 20 44 6f 20 6f | 74 68 65 72 0d 0a 61 6e |s. Do o|ther..an|
|000037e0| 74 69 65 70 69 6c 65 70 | 74 69 63 73 20 70 72 65 |tiepilep|tics pre|
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|00003800| 65 73 20 69 6e 20 63 68 | 69 6c 64 72 65 6e 20 69 |es in ch|ildren i|
|00003810| 64 65 6e 74 69 66 69 65 | 64 20 61 73 20 62 65 69 |dentifie|d as bei|
|00003820| 6e 67 20 61 74 0d 0a 69 | 6e 63 72 65 61 73 65 64 |ng at..i|ncreased|
|00003830| 20 72 69 73 6b 20 6f 66 | 20 72 65 63 75 72 72 65 | risk of| recurre|
|00003840| 6e 63 65 3f 0d 0a 20 20 | 20 20 20 54 68 65 72 65 |nce?.. | There|
|00003850| 20 69 73 20 6f 6e 65 20 | 66 6c 61 77 20 69 6e 20 | is one |flaw in |
|00003860| 74 68 69 73 20 73 74 75 | 64 79 2d 2d 69 74 20 64 |this stu|dy--it d|
|00003870| 69 64 20 6e 6f 74 20 74 | 61 6b 65 20 63 6f 6d 70 |id not t|ake comp|
|00003880| 6c 69 61 6e 63 65 20 69 | 6e 74 6f 20 61 63 63 6f |liance i|nto acco|
|00003890| 75 6e 74 2e 0d 0a 54 68 | 69 73 20 64 6f 65 73 20 |unt...Th|is does |
|000038a0| 6e 6f 74 20 74 6f 74 61 | 6c 6c 79 20 69 6e 76 61 |not tota|lly inva|
|000038b0| 6c 69 64 61 74 65 20 74 | 68 65 20 75 74 69 6c 69 |lidate t|he utili|
|000038c0| 74 79 20 6f 66 20 74 68 | 65 20 64 61 74 61 2c 20 |ty of th|e data, |
|000038d0| 62 75 74 20 69 74 20 70 | 72 65 76 65 6e 74 73 20 |but it p|revents |
|000038e0| 6f 6e 65 0d 0a 66 72 6f | 6d 20 73 61 79 69 6e 67 |one..fro|m saying|
|000038f0| 20 61 6e 79 74 68 69 6e | 67 20 61 62 6f 75 74 20 | anythin|g about |
|00003900| 62 65 6e 65 66 69 74 20 | 69 6e 20 70 61 74 69 65 |benefit |in patie|
|00003910| 6e 74 73 20 77 68 6f 20 | 73 63 72 75 70 75 6c 6f |nts who |scrupulo|
|00003920| 75 73 6c 79 20 74 61 6b | 65 20 74 68 65 69 72 0d |usly tak|e their.|
|00003930| 0a 64 72 75 67 2e 20 20 | 46 6f 72 20 74 68 69 73 |.drug. |For this|
|00003940| 20 6c 61 74 74 65 72 20 | 70 75 72 70 6f 73 65 2c | latter |purpose,|
|00003950| 20 22 69 6e 74 65 6e 74 | 69 6f 6e 20 74 6f 20 74 | "intent|ion to t|
|00003960| 72 65 61 74 20 61 6e 61 | 6c 79 73 69 73 22 20 69 |reat ana|lysis" i|
|00003970| 73 20 75 73 65 6c 65 73 | 73 2e 2d 2d 4c 2e 0d 0a |s useles|s.--L...|
|00003980| 4c 61 73 61 67 6e 61 2c | 20 4d 2e 44 2e 0d 0a 24 |Lasagna,| M.D...$|
|00003990| 55 6e 69 71 75 65 5f 49 | 44 7b 59 52 42 30 31 30 |Unique_I|D{YRB010|
|000039a0| 30 35 7d 0d 0a 24 54 69 | 74 6c 65 7b 47 61 62 61 |05}..$Ti|tle{Gaba|
|000039b0| 70 65 6e 74 69 6e 20 69 | 6e 20 50 61 72 74 69 61 |pentin i|n Partia|
|000039c0| 6c 20 45 70 69 6c 65 70 | 73 79 7d 0d 0a 24 41 75 |l Epilep|sy}..$Au|
|000039d0| 74 68 6f 72 7b 0d 0a 55 | 4b 20 47 61 62 61 70 65 |thor{..U|K Gabape|
|000039e0| 6e 74 69 6e 20 53 74 75 | 64 79 20 47 72 6f 75 70 |ntin Stu|dy Group|
|000039f0| 7d 0d 0a 24 41 66 66 69 | 6c 69 61 74 69 6f 6e 7b |}..$Affi|liation{|
|00003a00| 57 61 6c 74 6f 6e 20 48 | 6f 73 70 2c 20 4c 69 76 |Walton H|osp, Liv|
|00003a10| 65 72 70 6f 6f 6c 7d 0d | 0a 24 4a 6f 75 72 6e 61 |erpool}.|.$Journa|
|00003a20| 6c 7b 4c 61 6e 63 65 74 | 7d 0d 0a 24 56 6f 6c 75 |l{Lancet|}..$Volu|
|00003a30| 6d 65 7b 33 33 35 7d 0d | 0a 24 50 61 67 65 7b 31 |me{335}.|.$Page{1|
|00003a40| 31 31 34 2d 31 31 31 37 | 7d 0d 0a 24 44 61 74 65 |114-1117|}..$Date|
|00003a50| 7b 31 39 39 30 7d 0d 0a | 24 59 42 56 6f 6c 7b 31 |{1990}..|$YBVol{1|
|00003a60| 39 39 31 20 59 65 61 72 | 20 42 6f 6f 6b 20 6f 66 |991 Year| Book of|
|00003a70| 20 44 72 75 67 20 54 68 | 65 72 61 70 79 7d 0d 0a | Drug Th|erapy}..|
|00003a80| 24 43 68 61 70 74 65 72 | 7b 31 32 2d 33 7d 0d 0a |$Chapter|{12-3}..|
|00003a90| 24 59 42 45 64 69 74 6f | 72 7b 44 72 73 2e 20 4c |$YBEdito|r{Drs. L|
|00003aa0| 61 73 61 67 6e 61 20 61 | 6e 64 20 57 65 69 6e 74 |asagna a|nd Weint|
|00003ab0| 72 61 75 62 7d 0d 0a 24 | 54 61 62 6c 65 7b 7d 0d |raub}..$|Table{}.|
|00003ac0| 0a 24 43 6f 6d 6d 65 6e | 74 61 74 6f 72 7b 4d 2e |.$Commen|tator{M.|
|00003ad0| 20 57 65 69 6e 74 72 61 | 75 62 2c 20 4d 2e 44 2e | Weintra|ub, M.D.|
|00003ae0| 7d 0d 0a 0d 0a 43 6f 70 | 79 72 69 67 68 74 20 28 |}....Cop|yright (|
|00003af0| 43 29 20 59 65 61 72 20 | 42 6f 6f 6b 20 4d 65 64 |C) Year |Book Med|
|00003b00| 69 63 61 6c 20 50 75 62 | 6c 69 73 68 65 72 73 2c |ical Pub|lishers,|
|00003b10| 20 49 6e 63 2e 20 31 39 | 39 31 0d 0a 0d 0a 31 39 | Inc. 19|91....19|
|00003b20| 39 31 20 59 65 61 72 20 | 42 6f 6f 6b 20 6f 66 20 |91 Year |Book of |
|00003b30| 44 72 75 67 20 54 68 65 | 72 61 70 79 0d 0a 0d 0a |Drug The|rapy....|
|00003b40| 43 68 61 70 74 65 72 20 | 31 32 20 2d 2d 20 4e 65 |Chapter |12 -- Ne|
|00003b50| 75 72 6f 6c 6f 67 69 63 | 20 44 69 73 65 61 73 65 |urologic| Disease|
|00003b60| 73 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |s....---|--------|
|00003b70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003b90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003ba0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003bb0| 2d 2d 2d 0d 0a 47 61 62 | 61 70 65 6e 74 69 6e 20 |---..Gab|apentin |
|00003bc0| 69 6e 20 50 61 72 74 69 | 61 6c 20 45 70 69 6c 65 |in Parti|al Epile|
|00003bd0| 70 73 79 0d 0a 0d 0a 55 | 4b 20 47 61 62 61 70 65 |psy....U|K Gabape|
|00003be0| 6e 74 69 6e 20 53 74 75 | 64 79 20 47 72 6f 75 70 |ntin Stu|dy Group|
|00003bf0| 0d 0a 28 57 61 6c 74 6f | 6e 20 48 6f 73 70 2c 20 |..(Walto|n Hosp, |
|00003c00| 4c 69 76 65 72 70 6f 6f | 6c 29 0d 0a 4c 61 6e 63 |Liverpoo|l)..Lanc|
|00003c10| 65 74 20 33 33 35 3a 31 | 31 31 34 2d 31 31 31 37 |et 335:1|114-1117|
|00003c20| 2c 20 31 39 39 30 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |, 1990..|--------|
|00003c30| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c40| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003c70| 2d 2d 2d 2d 2d 2d 0d 0a | 0d 0a 41 62 73 74 72 61 |------..|..Abstra|
|00003c80| 63 74 0d 0a 0d 0a 20 20 | 20 20 20 47 61 62 61 70 |ct.... | Gabap|
|00003c90| 65 6e 74 69 6e 20 69 73 | 20 61 6e 20 61 6e 61 6c |entin is| an anal|
|00003ca0| 6f 67 75 65 20 6f 66 20 | 67 61 6d 6d 61 2d 61 6d |ogue of |gamma-am|
|00003cb0| 69 6e 6f 62 75 74 79 72 | 69 63 20 61 63 69 64 20 |inobutyr|ic acid |
|00003cc0| 77 69 74 68 20 61 6e 74 | 69 63 6f 6e 76 75 6c 73 |with ant|iconvuls|
|00003cd0| 61 6e 74 0d 0a 70 72 6f | 70 65 72 74 69 65 73 20 |ant..pro|perties |
|00003ce0| 69 6e 20 61 6e 69 6d 61 | 6c 73 2e 20 20 41 20 6d |in anima|ls. A m|
|00003cf0| 75 6c 74 69 63 65 6e 74 | 65 72 2c 20 64 6f 75 62 |ulticent|er, doub|
|00003d00| 6c 65 2d 62 6c 69 6e 64 | 2c 20 70 6c 61 63 65 62 |le-blind|, placeb|
|00003d10| 6f 2d 63 6f 6e 74 72 6f | 6c 6c 65 64 2c 0d 0a 70 |o-contro|lled,..p|
|00003d20| 61 72 61 6c 6c 65 6c 2d | 67 72 6f 75 70 20 63 6c |arallel-|group cl|
|00003d30| 69 6e 69 63 61 6c 20 74 | 72 69 61 6c 20 77 61 73 |inical t|rial was|
|00003d40| 20 63 6f 6e 64 75 63 74 | 65 64 20 74 6f 20 69 6e | conduct|ed to in|
|00003d50| 76 65 73 74 69 67 61 74 | 65 20 74 68 65 20 65 66 |vestigat|e the ef|
|00003d60| 66 69 63 61 63 79 20 6f | 66 0d 0a 67 61 62 61 70 |ficacy o|f..gabap|
|00003d70| 65 6e 74 69 6e 20 69 6e | 20 31 32 37 20 70 61 74 |entin in| 127 pat|
|00003d80| 69 65 6e 74 73 20 77 69 | 74 68 20 64 72 75 67 2d |ients wi|th drug-|
|00003d90| 72 65 73 69 73 74 61 6e | 74 20 70 61 72 74 69 61 |resistan|t partia|
|00003da0| 6c 20 65 70 69 6c 65 70 | 73 79 2e 20 20 53 69 78 |l epilep|sy. Six|
|00003db0| 74 79 2d 6f 6e 65 0d 0a | 77 65 72 65 20 67 69 76 |ty-one..|were giv|
|00003dc0| 65 6e 20 67 61 62 61 70 | 65 6e 74 69 6e 2c 20 31 |en gabap|entin, 1|
|00003dd0| 2c 32 30 30 20 6d 67 2f | 64 61 79 2c 20 61 73 20 |,200 mg/|day, as |
|00003de0| 61 64 64 69 74 69 6f 6e | 61 6c 20 74 68 65 72 61 |addition|al thera|
|00003df0| 70 79 2c 20 61 6e 64 20 | 36 36 20 72 65 63 65 69 |py, and |66 recei|
|00003e00| 76 65 64 20 61 0d 0a 6d | 61 74 63 68 65 64 20 70 |ved a..m|atched p|
|00003e10| 6c 61 63 65 62 6f 2c 20 | 66 6f 72 20 61 20 74 6f |lacebo, |for a to|
|00003e20| 74 61 6c 20 6f 66 20 31 | 32 20 77 65 65 6b 73 20 |tal of 1|2 weeks |
|00003e30| 6f 66 20 74 72 65 61 74 | 6d 65 6e 74 2e 20 20 42 |of treat|ment. B|
|00003e40| 61 73 65 6c 69 6e 65 20 | 73 65 69 7a 75 72 65 0d |aseline |seizure.|
|00003e50| 0a 66 72 65 71 75 65 6e | 63 79 20 61 6e 64 20 73 |.frequen|cy and s|
|00003e60| 74 61 6e 64 61 72 64 20 | 61 6e 74 69 63 6f 6e 76 |tandard |anticonv|
|00003e70| 75 6c 73 61 6e 74 20 70 | 6c 61 73 6d 61 20 63 6f |ulsant p|lasma co|
|00003e80| 6e 63 65 6e 74 72 61 74 | 69 6f 6e 73 20 77 65 72 |ncentrat|ions wer|
|00003e90| 65 20 65 73 74 61 62 6c | 69 73 68 65 64 0d 0a 6f |e establ|ished..o|
|00003ea0| 76 65 72 20 61 20 33 2d | 6d 6f 6e 74 68 20 6c 65 |ver a 3-|month le|
|00003eb0| 61 64 2d 69 6e 20 70 65 | 72 69 6f 64 2e 0d 0a 20 |ad-in pe|riod... |
|00003ec0| 20 20 20 20 54 68 65 20 | 66 72 65 71 75 65 6e 63 | The |frequenc|
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|00003ee0| 7a 75 72 65 73 20 77 61 | 73 20 61 74 20 6c 65 61 |zures wa|s at lea|
|00003ef0| 73 74 20 68 61 6c 76 65 | 64 20 69 6e 20 32 35 25 |st halve|d in 25%|
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|00003f30| 69 74 68 20 39 2e 38 25 | 20 6f 66 20 74 68 65 20 |ith 9.8%| of the |
|00003f40| 70 6c 61 63 65 62 6f 2d | 74 72 65 61 74 65 64 0d |placebo-|treated.|
|00003f50| 0a 70 61 74 69 65 6e 74 | 73 2e 20 20 54 68 65 20 |.patient|s. The |
|00003f60| 6d 65 61 6e 20 61 6e 64 | 20 6d 65 64 69 61 6e 20 |mean and| median |
|00003f70| 70 6c 61 73 6d 61 20 67 | 61 62 61 70 65 6e 74 69 |plasma g|abapenti|
|00003f80| 6e 20 63 6f 6e 63 65 6e | 74 72 61 74 69 6f 6e 73 |n concen|trations|
|00003f90| 20 77 65 72 65 20 68 69 | 67 68 65 72 20 69 6e 0d | were hi|gher in.|
|00003fa0| 0a 72 65 73 70 6f 6e 64 | 65 72 73 20 74 68 61 6e |.respond|ers than|
|00003fb0| 20 69 6e 20 6e 6f 6e 72 | 65 73 70 6f 6e 64 65 72 | in nonr|esponder|
|00003fc0| 73 2e 20 20 50 6c 61 73 | 6d 61 20 6c 65 76 65 6c |s. Plas|ma level|
|00003fd0| 73 20 6f 66 20 6f 74 68 | 65 72 20 61 6e 74 69 63 |s of oth|er antic|
|00003fe0| 6f 6e 76 75 6c 73 61 6e | 74 20 64 72 75 67 73 0d |onvulsan|t drugs.|
|00003ff0| 0a 77 65 72 65 20 6e 6f | 74 20 63 68 61 6e 67 65 |.were no|t change|
|00004000| 64 20 73 69 67 6e 69 66 | 69 63 61 6e 74 6c 79 20 |d signif|icantly |
|00004010| 62 79 20 67 61 62 61 70 | 65 6e 74 69 6e 20 74 68 |by gabap|entin th|
|00004020| 65 72 61 70 79 2e 20 20 | 4d 69 6c 64 20 74 6f 20 |erapy. |Mild to |
|00004030| 6d 6f 64 65 72 61 74 65 | 20 73 69 64 65 0d 0a 65 |moderate| side..e|
|00004040| 66 66 65 63 74 73 20 6f | 63 63 75 72 72 65 64 20 |ffects o|ccurred |
|00004050| 69 6e 20 36 32 25 20 6f | 66 20 67 61 62 61 70 65 |in 62% o|f gabape|
|00004060| 6e 74 69 6e 2d 74 72 65 | 61 74 65 64 20 70 61 74 |ntin-tre|ated pat|
|00004070| 69 65 6e 74 73 20 61 6e | 64 20 34 31 25 20 6f 66 |ients an|d 41% of|
|00004080| 0d 0a 70 6c 61 63 65 62 | 6f 2d 74 72 65 61 74 65 |..placeb|o-treate|
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|000040a0| 6e 6f 6c 65 6e 63 65 20 | 61 6e 64 20 66 61 74 69 |nolence |and fati|
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|000040c0| 74 20 63 6f 6d 6d 6f 6e | 20 73 69 64 65 0d 0a 65 |t common| side..e|
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|000040f0| 74 69 6e 2c 20 31 2c 32 | 30 30 20 6d 67 20 64 61 |tin, 1,2|00 mg da|
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|00004110| 0d 0a 61 6e 74 69 63 6f | 6e 76 75 6c 73 61 6e 74 |..antico|nvulsant|
|00004120| 20 74 68 65 72 61 70 79 | 20 68 61 73 20 61 6e 20 | therapy| has an |
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|00004140| 70 69 6c 65 70 74 69 63 | 20 65 66 66 65 63 74 20 |pileptic| effect |
|00004150| 69 6e 20 70 61 74 69 65 | 6e 74 73 20 77 69 74 68 |in patie|nts with|
|00004160| 0d 0a 73 65 76 65 72 65 | 20 64 72 75 67 2d 72 65 |..severe| drug-re|
|00004170| 73 69 73 74 61 6e 74 20 | 70 61 72 74 69 61 6c 20 |sistant |partial |
|00004180| 65 70 69 6c 65 70 73 79 | 2e 0d 0a 0d 0a 50 6f 73 |epilepsy|.....Pos|
|00004190| 74 2d 43 6f 6d 6d 65 6e | 74 0d 0a 0d 0a 20 20 20 |t-Commen|t.... |
|000041a0| 20 20 49 6e 20 65 70 69 | 6c 65 70 73 79 2c 20 65 | In epi|lepsy, e|
|000041b0| 61 72 6c 79 20 69 6e 76 | 65 73 74 69 67 61 74 69 |arly inv|estigati|
|000041c0| 6f 6e 73 20 6f 66 20 61 | 20 6d 65 64 69 63 61 74 |ons of a| medicat|
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|000041f0| 74 65 73 74 20 64 72 75 | 67 20 74 6f 20 63 75 72 |test dru|g to cur|
|00004200| 72 65 6e 74 20 74 68 65 | 72 61 70 79 20 69 6e 20 |rent the|rapy in |
|00004210| 70 61 74 69 65 6e 74 73 | 20 77 68 6f 73 65 20 64 |patients| whose d|
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|00004320| 75 74 0d 0a 74 68 61 74 | 20 74 68 65 20 69 6c 6c |ut..that| the ill|
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|00005130| 66 66 65 63 74 73 2e 0d | 0a 50 69 6d 6f 7a 69 64 |ffects..|.Pimozid|
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|00005150| 68 20 62 6c 6f 63 6b 61 | 64 65 20 6f 66 20 63 65 |h blocka|de of ce|
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|00005190| 76 6f 6b 65 64 20 69 6e | 20 6f 74 68 65 72 20 6e |voked in| other n|
|000051a0| 65 75 72 6f 74 72 61 6e | 73 6d 69 74 74 65 72 20 |eurotran|smitter |
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|000051c0| 66 65 72 65 6e 63 65 20 | 6f 66 20 64 6f 70 61 6d |ference |of dopam|
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|000051f0| 43 6f 6d 6d 65 6e 74 0d | 0a 0d 0a 20 20 20 20 20 |Comment.|... |
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|00005220| 6f 76 65 72 20 64 65 73 | 69 67 6e 20 69 73 20 74 |over des|ign is t|
|00005230| 68 61 74 20 74 68 65 20 | 70 61 72 74 69 63 69 70 |hat the |particip|
|00005240| 61 6e 74 73 0d 0a 72 65 | 74 75 72 6e 20 6d 6f 72 |ants..re|turn mor|
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|00005260| 6f 20 62 61 73 65 6c 69 | 6e 65 20 63 6f 6e 64 69 |o baseli|ne condi|
|00005270| 74 69 6f 6e 73 20 62 65 | 66 6f 72 65 20 69 6e 73 |tions be|fore ins|
|00005280| 74 69 74 75 74 69 6e 67 | 20 74 68 65 20 6e 65 78 |tituting| the nex|
|00005290| 74 0d 0a 74 68 65 72 61 | 70 79 20 69 6e 20 74 68 |t..thera|py in th|
|000052a0| 65 20 63 79 63 6c 65 2e | 20 20 41 73 20 73 68 6f |e cycle.| As sho|
|000052b0| 77 6e 20 69 6e 20 46 69 | 67 75 72 65 20 31 32 2d |wn in Fi|gure 12-|
|000052c0| 31 2c 20 77 69 74 68 6f | 75 74 20 70 61 72 74 69 |1, witho|ut parti|
|000052d0| 63 69 70 61 6e 74 73 20 | 6f 72 0d 0a 69 6e 74 65 |cipants |or..inte|
|000052e0| 72 76 69 65 77 65 72 73 | 20 61 77 61 72 65 20 6f |rviewers| aware o|
|000052f0| 66 20 74 68 65 20 74 72 | 65 61 74 6d 65 6e 74 20 |f the tr|eatment |
|00005300| 64 65 73 69 67 6e 20 61 | 6e 64 20 74 68 65 20 63 |design a|nd the c|
|00005310| 72 6f 73 73 6f 76 65 72 | 20 70 6f 69 6e 74 2c 0d |rossover| point,.|
|00005320| 0a 70 61 72 74 69 63 69 | 70 61 6e 74 73 20 64 69 |.partici|pants di|
|00005330| 64 20 72 65 74 75 72 6e | 20 62 61 63 6b 20 74 6f |d return| back to|
|00005340| 20 62 61 73 65 6c 69 6e | 65 20 73 74 61 74 75 73 | baselin|e status|
|00005350| 2e 20 20 41 20 70 6c 61 | 63 65 62 6f 20 77 61 73 |. A pla|cebo was|
|00005360| 68 2d 6f 75 74 20 77 61 | 73 20 75 73 65 64 0d 0a |h-out wa|s used..|
|00005370| 74 6f 20 63 6f 76 65 72 | 20 74 68 65 20 61 62 72 |to cover| the abr|
|00005380| 75 70 74 20 77 69 74 68 | 64 72 61 77 61 6c 20 6f |upt with|drawal o|
|00005390| 66 20 61 63 74 69 76 65 | 20 6d 65 64 69 63 61 74 |f active| medicat|
|000053a0| 69 6f 6e 2e 0d 0a 20 20 | 20 20 20 41 6e 6f 74 68 |ion... | Anoth|
|000053b0| 65 72 20 69 6e 74 65 72 | 65 73 74 69 6e 67 20 70 |er inter|esting p|
|000053c0| 6f 69 6e 74 20 69 6e 20 | 74 68 65 20 73 74 75 64 |oint in |the stud|
|000053d0| 79 20 69 73 20 74 68 61 | 74 20 70 61 74 69 65 6e |y is tha|t patien|
|000053e0| 74 73 20 77 68 6f 20 68 | 61 64 0d 0a 70 72 65 76 |ts who h|ad..prev|
|000053f0| 69 6f 75 73 6c 79 20 6e | 6f 74 20 72 65 73 70 6f |iously n|ot respo|
|00005400| 6e 64 65 64 20 74 6f 20 | 63 61 72 62 61 6d 61 7a |nded to |carbamaz|
|00005410| 65 70 69 6e 65 20 64 69 | 64 20 69 6d 70 72 6f 76 |epine di|d improv|
|00005420| 65 20 77 68 65 6e 20 69 | 74 20 77 61 73 20 67 69 |e when i|t was gi|
|00005430| 76 65 6e 20 64 75 72 69 | 6e 67 0d 0a 74 68 65 20 |ven duri|ng..the |
|00005440| 73 74 75 64 79 2e 20 20 | 42 6f 74 68 20 74 68 65 |study. |Both the|
|00005450| 20 6f 76 65 72 61 6c 6c | 20 6d 65 61 6e 20 72 65 | overall| mean re|
|00005460| 73 70 6f 6e 73 65 20 61 | 6e 64 20 6d 6f 72 65 20 |sponse a|nd more |
|00005470| 74 68 61 6e 20 35 30 25 | 20 6f 66 20 74 68 65 20 |than 50%| of the |
|00005480| 69 6e 64 69 76 69 64 75 | 61 6c 0d 0a 70 61 74 69 |individu|al..pati|
|00005490| 65 6e 74 73 20 69 6d 70 | 72 6f 76 65 64 20 77 69 |ents imp|roved wi|
|000054a0| 74 68 20 63 61 72 62 61 | 6d 61 7a 65 70 69 6e 65 |th carba|mazepine|
|000054b0| 20 74 68 65 72 61 70 79 | 2e 20 20 50 65 72 68 61 | therapy|. Perha|
|000054c0| 70 73 20 74 68 65 20 64 | 6f 73 65 20 74 69 74 72 |ps the d|ose titr|
|000054d0| 61 74 69 6f 6e 0d 0a 61 | 63 63 6f 75 6e 74 65 64 |ation..a|ccounted|
|000054e0| 20 66 6f 72 20 74 68 65 | 20 69 6d 70 72 6f 76 65 | for the| improve|
|000054f0| 6d 65 6e 74 2e 20 20 41 | 20 73 74 72 6f 6e 67 20 |ment. A| strong |
|00005500| 69 6d 70 6c 69 63 61 74 | 69 6f 6e 20 6f 66 20 74 |implicat|ion of t|
|00005510| 68 65 20 72 65 73 75 6c | 74 73 20 69 73 20 74 68 |he resul|ts is th|
|00005520| 61 74 0d 0a 65 76 65 6e | 20 74 68 6f 75 67 68 20 |at..even| though |
|00005530| 61 20 74 72 65 61 74 6d | 65 6e 74 20 66 61 69 6c |a treatm|ent fail|
|00005540| 65 64 20 74 6f 20 68 65 | 6c 70 20 61 20 70 61 74 |ed to he|lp a pat|
|00005550| 69 65 6e 74 20 69 6e 20 | 74 68 65 20 70 61 73 74 |ient in |the past|
|00005560| 2c 20 69 74 20 6d 61 79 | 20 62 65 0d 0a 76 61 6c |, it may| be..val|
|00005570| 75 61 62 6c 65 20 74 6f | 20 74 72 79 20 74 68 61 |uable to| try tha|
|00005580| 74 20 74 72 65 61 74 6d | 65 6e 74 20 61 67 61 69 |t treatm|ent agai|
|00005590| 6e 2e 20 20 50 65 72 68 | 61 70 73 20 74 68 65 20 |n. Perh|aps the |
|000055a0| 70 61 74 69 65 6e 74 20 | 61 6e 64 20 74 68 65 20 |patient |and the |
|000055b0| 64 69 73 65 61 73 65 0d | 0a 68 61 76 65 20 63 68 |disease.|.have ch|
|000055c0| 61 6e 67 65 64 2c 20 6f | 72 20 77 65 20 63 6f 75 |anged, o|r we cou|
|000055d0| 6c 64 20 6d 61 6e 61 67 | 65 20 74 68 65 20 69 6e |ld manag|e the in|
|000055e0| 74 65 72 76 65 6e 74 69 | 6f 6e 20 6d 6f 72 65 20 |terventi|on more |
|000055f0| 65 66 66 65 63 74 69 76 | 65 6c 79 2e 2d 2d 4d 2e |effectiv|ely.--M.|
|00005600| 0d 0a 57 65 69 6e 74 72 | 61 75 62 2c 20 4d 2e 44 |..Weintr|aub, M.D|
|00005610| 2e 0d 0a 24 55 6e 69 71 | 75 65 5f 49 44 7b 59 52 |...$Uniq|ue_ID{YR|
|00005620| 42 30 31 30 30 37 7d 0d | 0a 24 54 69 74 6c 65 7b |B01007}.|.$Title{|
|00005630| 54 68 65 20 45 66 66 65 | 63 74 20 6f 66 20 44 65 |The Effe|ct of De|
|00005640| 70 72 65 6e 79 6c 20 28 | 53 65 6c 65 67 69 6c 69 |prenyl (|Selegili|
|00005650| 6e 65 29 20 6f 6e 20 74 | 68 65 20 4e 61 74 75 72 |ne) on t|he Natur|
|00005660| 61 6c 20 48 69 73 74 6f | 72 79 20 6f 66 0d 0a 50 |al Histo|ry of..P|
|00005670| 61 72 6b 69 6e 73 6f 6e | 27 73 20 44 69 73 65 61 |arkinson|'s Disea|
|00005680| 73 65 7d 0d 0a 24 41 75 | 74 68 6f 72 7b 0d 0a 54 |se}..$Au|thor{..T|
|00005690| 65 74 72 75 64 2c 20 4a | 57 0d 0a 4c 61 6e 67 73 |etrud, J|W..Langs|
|000056a0| 74 6f 6e 2c 20 4a 57 7d | 0d 0a 24 41 66 66 69 6c |ton, JW}|..$Affil|
|000056b0| 69 61 74 69 6f 6e 7b 43 | 61 6c 69 66 6f 72 6e 69 |iation{C|aliforni|
|000056c0| 61 20 50 61 72 6b 69 6e | 73 6f 6e 27 73 20 46 6f |a Parkin|son's Fo|
|000056d0| 75 6e 64 2c 20 53 61 6e | 20 4a 6f 73 65 7d 0d 0a |und, San| Jose}..|
|000056e0| 24 4a 6f 75 72 6e 61 6c | 7b 53 63 69 65 6e 63 65 |$Journal|{Science|
|000056f0| 7d 0d 0a 24 56 6f 6c 75 | 6d 65 7b 32 34 35 7d 0d |}..$Volu|me{245}.|
|00005700| 0a 24 50 61 67 65 7b 35 | 31 39 2d 35 32 32 7d 0d |.$Page{5|19-522}.|
|00005710| 0a 24 44 61 74 65 7b 31 | 39 38 39 7d 0d 0a 24 59 |.$Date{1|989}..$Y|
|00005720| 42 56 6f 6c 7b 31 39 39 | 31 20 59 65 61 72 20 42 |BVol{199|1 Year B|
|00005730| 6f 6f 6b 20 6f 66 20 44 | 72 75 67 20 54 68 65 72 |ook of D|rug Ther|
|00005740| 61 70 79 7d 0d 0a 24 43 | 68 61 70 74 65 72 7b 31 |apy}..$C|hapter{1|
|00005750| 32 2d 35 7d 0d 0a 24 59 | 42 45 64 69 74 6f 72 7b |2-5}..$Y|BEditor{|
|00005760| 44 72 73 2e 20 4c 61 73 | 61 67 6e 61 20 61 6e 64 |Drs. Las|agna and|
|00005770| 20 57 65 69 6e 74 72 61 | 75 62 7d 0d 0a 24 54 61 | Weintra|ub}..$Ta|
|00005780| 62 6c 65 7b 7d 0d 0a 24 | 43 6f 6d 6d 65 6e 74 61 |ble{}..$|Commenta|
|00005790| 74 6f 72 7b 4d 2e 20 57 | 65 69 6e 74 72 61 75 62 |tor{M. W|eintraub|
|000057a0| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|000057b0| 69 67 68 74 20 28 43 29 | 20 59 65 61 72 20 42 6f |ight (C)| Year Bo|
|000057c0| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|000057d0| 73 68 65 72 73 2c 20 49 | 6e 63 2e 20 31 39 39 31 |shers, I|nc. 1991|
|000057e0| 0d 0a 0d 0a 31 39 39 31 | 20 59 65 61 72 20 42 6f |....1991| Year Bo|
|000057f0| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|00005800| 70 79 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 31 32 |py....Ch|apter 12|
|00005810| 20 2d 2d 20 4e 65 75 72 | 6f 6c 6f 67 69 63 20 44 | -- Neur|ologic D|
|00005820| 69 73 65 61 73 65 73 0d | 0a 0d 0a 2d 2d 2d 2d 2d |iseases.|...-----|
|00005830| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005850| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005860| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005870| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 54 68 65 20 45 |--------|-..The E|
|00005880| 66 66 65 63 74 20 6f 66 | 20 44 65 70 72 65 6e 79 |ffect of| Depreny|
|00005890| 6c 20 28 53 65 6c 65 67 | 69 6c 69 6e 65 29 20 6f |l (Seleg|iline) o|
|000058a0| 6e 20 74 68 65 20 4e 61 | 74 75 72 61 6c 20 48 69 |n the Na|tural Hi|
|000058b0| 73 74 6f 72 79 20 6f 66 | 20 50 61 72 6b 69 6e 73 |story of| Parkins|
|000058c0| 6f 6e 27 73 0d 0a 44 69 | 73 65 61 73 65 0d 0a 0d |on's..Di|sease...|
|000058d0| 0a 54 65 74 72 75 64 20 | 4a 57 3b 20 4c 61 6e 67 |.Tetrud |JW; Lang|
|000058e0| 73 74 6f 6e 20 4a 57 0d | 0a 28 43 61 6c 69 66 6f |ston JW.|.(Califo|
|000058f0| 72 6e 69 61 20 50 61 72 | 6b 69 6e 73 6f 6e 27 73 |rnia Par|kinson's|
|00005900| 20 46 6f 75 6e 64 2c 20 | 53 61 6e 20 4a 6f 73 65 | Found, |San Jose|
|00005910| 29 0d 0a 53 63 69 65 6e | 63 65 20 32 34 35 3a 35 |)..Scien|ce 245:5|
|00005920| 31 39 2d 35 32 32 2c 20 | 31 39 38 39 0d 0a 2d 2d |19-522, |1989..--|
|00005930| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005940| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00005980| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00005990| 20 54 68 65 20 65 66 66 | 65 63 74 73 20 6f 66 20 | The eff|ects of |
|000059a0| 31 2d 6d 65 74 68 79 6c | 2d 34 2d 70 68 65 6e 79 |1-methyl|-4-pheny|
|000059b0| 6c 2d 31 2c 32 2c 33 2c | 36 2d 74 65 74 72 61 68 |l-1,2,3,|6-tetrah|
|000059c0| 79 64 72 6f 70 79 72 69 | 64 69 6e 65 20 28 4d 50 |ydropyri|dine (MP|
|000059d0| 54 50 29 2c 20 61 0d 0a | 6e 65 75 72 6f 74 6f 78 |TP), a..|neurotox|
|000059e0| 69 6e 20 74 68 61 74 20 | 69 6e 64 75 63 65 73 20 |in that |induces |
|000059f0| 50 61 72 6b 69 6e 73 6f | 6e 27 73 20 64 69 73 65 |Parkinso|n's dise|
|00005a00| 61 73 65 20 73 79 6d 70 | 74 6f 6d 73 2c 20 63 61 |ase symp|toms, ca|
|00005a10| 6e 20 62 65 20 70 72 65 | 76 65 6e 74 65 64 20 69 |n be pre|vented i|
|00005a20| 6e 0d 0a 61 6e 69 6d 61 | 6c 73 20 62 79 20 69 6e |n..anima|ls by in|
|00005a30| 68 69 62 69 74 69 6e 67 | 20 6d 6f 6e 6f 61 6d 69 |hibiting| monoami|
|00005a40| 6e 65 20 6f 78 69 64 61 | 73 65 20 42 2e 20 20 41 |ne oxida|se B. A|
|00005a50| 20 64 6f 75 62 6c 65 2d | 62 6c 69 6e 64 2c 20 70 | double-|blind, p|
|00005a60| 6c 61 63 65 62 6f 2d 63 | 6f 6e 74 72 6f 6c 6c 65 |lacebo-c|ontrolle|
|00005a70| 64 0d 0a 73 74 75 64 79 | 20 6f 66 20 64 65 70 72 |d..study| of depr|
|00005a80| 65 6e 79 6c 2c 20 31 30 | 20 6d 67 2f 64 61 79 2c |enyl, 10| mg/day,|
|00005a90| 20 61 20 73 65 6c 65 63 | 74 69 76 65 20 6d 6f 6e | a selec|tive mon|
|00005aa0| 6f 61 6d 69 6e 65 20 6f | 78 69 64 61 73 65 20 42 |oamine o|xidase B|
|00005ab0| 20 69 6e 68 69 62 69 74 | 6f 72 2c 20 77 61 73 0d | inhibit|or, was.|
|00005ac0| 0a 63 6f 6e 64 75 63 74 | 65 64 20 69 6e 20 35 34 |.conduct|ed in 54|
|00005ad0| 20 70 61 74 69 65 6e 74 | 73 20 77 69 74 68 20 65 | patient|s with e|
|00005ae0| 61 72 6c 79 20 50 61 72 | 6b 69 6e 73 6f 6e 27 73 |arly Par|kinson's|
|00005af0| 20 64 69 73 65 61 73 65 | 2e 20 20 54 68 65 20 70 | disease|. The p|
|00005b00| 61 74 69 65 6e 74 73 20 | 77 65 72 65 0d 0a 66 6f |atients |were..fo|
|00005b10| 6c 6c 6f 77 65 64 20 75 | 6e 74 69 6c 20 74 68 65 |llowed u|ntil the|
|00005b20| 79 20 72 65 71 75 69 72 | 65 64 20 4c 2d 64 6f 70 |y requir|ed L-dop|
|00005b30| 61 20 74 68 65 72 61 70 | 79 2c 20 6f 72 20 66 6f |a therap|y, or fo|
|00005b40| 72 20 33 20 64 61 79 73 | 2e 0d 0a 20 20 20 20 20 |r 3 days|... |
|00005b50| 54 68 65 20 61 76 65 72 | 61 67 65 20 74 69 6d 65 |The aver|age time|
|00005b60| 20 74 6f 20 4c 2d 64 6f | 70 61 20 74 68 65 72 61 | to L-do|pa thera|
|00005b70| 70 79 20 77 61 73 20 33 | 31 32 20 64 61 79 73 20 |py was 3|12 days |
|00005b80| 66 6f 72 20 74 68 65 20 | 70 6c 61 63 65 62 6f 20 |for the |placebo |
|00005b90| 67 72 6f 75 70 20 61 6e | 64 0d 0a 35 34 39 20 64 |group an|d..549 d|
|00005ba0| 61 79 73 20 66 6f 72 20 | 74 68 65 20 64 65 70 72 |ays for |the depr|
|00005bb0| 65 6e 79 6c 20 67 72 6f | 75 70 3b 20 74 68 65 20 |enyl gro|up; the |
|00005bc0| 64 69 66 66 65 72 65 6e | 63 65 20 77 61 73 20 73 |differen|ce was s|
|00005bd0| 69 67 6e 69 66 69 63 61 | 6e 74 2e 20 20 44 69 73 |ignifica|nt. Dis|
|00005be0| 65 61 73 65 0d 0a 70 72 | 6f 67 72 65 73 73 69 6f |ease..pr|ogressio|
|00005bf0| 6e 20 77 61 73 20 6d 6f | 6e 69 74 6f 72 65 64 20 |n was mo|nitored |
|00005c00| 62 79 20 35 20 64 69 66 | 66 65 72 65 6e 74 20 61 |by 5 dif|ferent a|
|00005c10| 73 73 65 73 73 6d 65 6e | 74 20 73 63 61 6c 65 73 |ssessmen|t scales|
|00005c20| 2c 20 61 6e 64 20 77 61 | 73 20 73 6c 6f 77 65 64 |, and wa|s slowed|
|00005c30| 0d 0a 66 72 6f 6d 20 34 | 30 25 20 74 6f 20 38 33 |..from 4|0% to 83|
|00005c40| 25 20 70 65 72 20 79 65 | 61 72 20 69 6e 20 74 68 |% per ye|ar in th|
|00005c50| 65 20 64 65 70 72 65 6e | 79 6c 20 67 72 6f 75 70 |e depren|yl group|
|00005c60| 2e 20 20 54 68 65 72 65 | 20 77 65 72 65 20 66 65 |. There| were fe|
|00005c70| 77 20 73 69 64 65 20 65 | 66 66 65 63 74 73 0d 0a |w side e|ffects..|
|00005c80| 66 72 6f 6d 20 64 65 70 | 72 65 6e 79 6c 20 75 73 |from dep|renyl us|
|00005c90| 61 67 65 2e 0d 0a 20 20 | 20 20 20 44 65 70 72 65 |age... | Depre|
|00005ca0| 6e 79 6c 20 61 70 70 65 | 61 72 73 20 74 6f 20 62 |nyl appe|ars to b|
|00005cb0| 65 20 61 20 76 65 72 79 | 20 73 61 66 65 20 64 72 |e a very| safe dr|
|00005cc0| 75 67 20 69 6e 20 70 61 | 74 69 65 6e 74 73 20 77 |ug in pa|tients w|
|00005cd0| 69 74 68 20 65 61 72 6c | 79 0d 0a 50 61 72 6b 69 |ith earl|y..Parki|
|00005ce0| 6e 73 6f 6e 27 73 20 64 | 69 73 65 61 73 65 2e 20 |nson's d|isease. |
|00005cf0| 20 54 72 65 61 74 6d 65 | 6e 74 20 77 69 74 68 20 | Treatme|nt with |
|00005d00| 64 65 70 72 65 6e 79 6c | 20 73 69 67 6e 69 66 69 |deprenyl| signifi|
|00005d10| 63 61 6e 74 6c 79 20 64 | 65 6c 61 79 73 20 74 68 |cantly d|elays th|
|00005d20| 65 20 6e 65 65 64 0d 0a | 66 6f 72 20 4c 2d 64 6f |e need..|for L-do|
|00005d30| 70 61 20 74 72 65 61 74 | 6d 65 6e 74 20 61 6e 64 |pa treat|ment and|
|00005d40| 20 61 70 70 65 61 72 73 | 20 74 6f 20 73 6c 6f 77 | appears| to slow|
|00005d50| 20 74 68 65 20 72 61 74 | 65 20 6f 66 20 50 61 72 | the rat|e of Par|
|00005d60| 6b 69 6e 73 6f 6e 27 73 | 20 64 69 73 65 61 73 65 |kinson's| disease|
|00005d70| 0d 0a 70 72 6f 67 72 65 | 73 73 69 6f 6e 2e 20 20 |..progre|ssion. |
|00005d80| 41 20 6c 61 72 67 65 20 | 6d 75 6c 74 69 2d 69 6e |A large |multi-in|
|00005d90| 73 74 69 74 75 74 69 6f | 6e 61 6c 20 73 74 75 64 |stitutio|nal stud|
|00005da0| 79 20 69 73 20 6e 6f 77 | 20 75 6e 64 65 72 20 77 |y is now| under w|
|00005db0| 61 79 20 74 6f 20 63 6f | 6e 66 69 72 6d 0d 0a 74 |ay to co|nfirm..t|
|00005dc0| 68 65 73 65 20 72 65 73 | 75 6c 74 73 2e 0d 0a 0d |hese res|ults....|
|00005dd0| 0a 50 6f 73 74 2d 43 6f | 6d 6d 65 6e 74 0d 0a 0d |.Post-Co|mment...|
|00005de0| 0a 20 20 20 20 20 49 6e | 20 61 64 64 69 74 69 6f |. In| additio|
|00005df0| 6e 20 74 6f 20 74 68 65 | 20 69 6e 74 65 72 65 73 |n to the| interes|
|00005e00| 74 69 6e 67 20 72 65 73 | 75 6c 74 73 20 6f 66 20 |ting res|ults of |
|00005e10| 74 68 69 73 20 73 74 75 | 64 79 2c 20 63 6f 6e 66 |this stu|dy, conf|
|00005e20| 69 72 6d 65 64 20 62 79 | 0d 0a 61 6e 6f 74 68 65 |irmed by|..anothe|
|00005e30| 72 20 70 61 70 65 72 20 | 28 31 29 2c 20 69 73 20 |r paper |(1), is |
|00005e40| 74 68 65 20 70 6f 69 6e | 74 20 74 68 61 74 20 74 |the poin|t that t|
|00005e50| 68 65 20 6f 75 74 63 6f | 6d 65 20 69 6e 20 6d 61 |he outco|me in ma|
|00005e60| 6e 79 20 73 74 75 64 69 | 65 73 20 6f 66 20 63 68 |ny studi|es of ch|
|00005e70| 72 6f 6e 69 63 0d 0a 69 | 6c 6c 6e 65 73 73 65 73 |ronic..i|llnesses|
|00005e80| 20 6d 61 79 20 62 65 20 | 61 20 63 68 61 6e 67 65 | may be |a change|
|00005e90| 20 69 6e 20 74 68 65 20 | 73 6c 6f 70 65 20 6f 66 | in the |slope of|
|00005ea0| 20 74 68 65 20 64 65 74 | 65 72 69 6f 72 61 74 69 | the det|eriorati|
|00005eb0| 6f 6e 20 63 75 72 76 65 | 2e 20 20 4e 6f 20 63 75 |on curve|. No cu|
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|00005ed0| 20 69 6e 20 74 68 69 73 | 20 73 74 75 64 79 2e 20 | in this| study. |
|00005ee0| 20 54 68 65 20 6d 61 69 | 6e 20 6f 75 74 63 6f 6d | The mai|n outcom|
|00005ef0| 65 20 63 72 69 74 65 72 | 69 6f 6e 20 77 61 73 20 |e criter|ion was |
|00005f00| 61 20 64 65 6c 61 79 20 | 69 6e 20 74 68 65 0d 0a |a delay |in the..|
|00005f10| 6e 65 65 64 20 66 6f 72 | 20 4c 2d 64 6f 70 61 20 |need for| L-dopa |
|00005f20| 74 68 65 72 61 70 79 2e | 20 20 41 64 64 69 74 69 |therapy.| Additi|
|00005f30| 6f 6e 61 6c 6c 79 2c 20 | 64 69 73 65 61 73 65 20 |onally, |disease |
|00005f40| 70 72 6f 67 72 65 73 73 | 69 6f 6e 20 6f 6e 20 73 |progress|ion on s|
|00005f50| 65 76 65 72 61 6c 0d 0a | 61 73 73 65 73 73 6d 65 |everal..|assessme|
|00005f60| 6e 74 20 73 63 61 6c 65 | 73 20 77 61 73 20 73 69 |nt scale|s was si|
|00005f70| 67 6e 69 66 69 63 61 6e | 74 6c 79 20 73 6c 6f 77 |gnifican|tly slow|
|00005f80| 65 64 20 62 79 20 74 68 | 65 20 6d 6f 6e 6f 61 6d |ed by th|e monoam|
|00005f90| 69 6e 65 20 6f 78 69 64 | 61 73 65 0d 0a 42 2d 69 |ine oxid|ase..B-i|
|00005fa0| 6e 68 69 62 69 74 69 6e | 67 20 6d 65 64 69 63 61 |nhibitin|g medica|
|00005fb0| 74 69 6f 6e 2e 20 20 45 | 76 61 6c 75 61 74 69 6e |tion. E|valuatin|
|00005fc0| 67 20 74 68 65 20 72 65 | 73 75 6c 74 73 20 6f 66 |g the re|sults of|
|00005fd0| 20 63 6c 69 6e 69 63 61 | 6c 20 74 72 69 61 6c 73 | clinica|l trials|
|00005fe0| 20 69 6e 20 63 68 72 6f | 6e 69 63 0d 0a 69 6c 6c | in chro|nic..ill|
|00005ff0| 6e 65 73 73 65 73 20 77 | 69 6c 6c 20 69 6e 63 72 |nesses w|ill incr|
|00006000| 65 61 73 69 6e 67 6c 79 | 20 64 65 70 65 6e 64 20 |easingly| depend |
|00006010| 6f 6e 20 63 68 61 6e 67 | 65 73 20 73 75 63 68 20 |on chang|es such |
|00006020| 61 73 20 73 6c 6f 77 69 | 6e 67 20 6f 66 20 77 6f |as slowi|ng of wo|
|00006030| 72 73 65 6e 69 6e 67 2c | 20 61 73 0d 0a 73 65 65 |rsening,| as..see|
|00006040| 6e 20 69 6e 20 74 68 69 | 73 20 73 74 75 64 79 2e |n in thi|s study.|
|00006050| 2d 2d 4d 2e 20 57 65 69 | 6e 74 72 61 75 62 2c 20 |--M. Wei|ntraub, |
|00006060| 4d 2e 44 2e 0d 0a 24 55 | 6e 69 71 75 65 5f 49 44 |M.D...$U|nique_ID|
|00006070| 7b 59 52 42 30 31 30 30 | 38 7d 0d 0a 24 54 69 74 |{YRB0100|8}..$Tit|
|00006080| 6c 65 7b 43 6f 6e 63 65 | 6e 74 72 61 74 69 6f 6e |le{Conce|ntration|
|00006090| 2d 52 65 73 70 6f 6e 73 | 65 20 52 65 6c 61 74 69 |-Respons|e Relati|
|000060a0| 6f 6e 73 68 69 70 20 69 | 6e 20 49 6d 69 70 72 61 |onship i|n Imipra|
|000060b0| 6d 69 6e 65 20 54 72 65 | 61 74 6d 65 6e 74 20 6f |mine Tre|atment o|
|000060c0| 66 20 44 69 61 62 65 74 | 69 63 0d 0a 4e 65 75 72 |f Diabet|ic..Neur|
|000060d0| 6f 70 61 74 68 79 20 53 | 79 6d 70 74 6f 6d 73 7d |opathy S|ymptoms}|
|000060e0| 0d 0a 24 41 75 74 68 6f | 72 7b 0d 0a 53 69 6e 64 |..$Autho|r{..Sind|
|000060f0| 72 75 70 2c 20 53 48 0d | 0a 47 72 61 6d 2c 20 4c |rup, SH.|.Gram, L|
|00006100| 46 0d 0a 53 6b 6a 6f 6c | 64 2c 20 54 0d 0a 46 72 |F..Skjol|d, T..Fr|
|00006110| 6f 6c 61 6e 64 2c 20 41 | 0d 0a 42 65 63 6b 2d 4e |oland, A|..Beck-N|
|00006120| 69 65 6c 73 65 6e 2c 20 | 48 7d 0d 0a 24 41 66 66 |ielsen, |H}..$Aff|
|00006130| 69 6c 69 61 74 69 6f 6e | 7b 4f 64 65 6e 73 65 20 |iliation|{Odense |
|00006140| 55 6e 69 76 2c 20 4f 64 | 65 6e 73 65 2c 20 44 65 |Univ, Od|ense, De|
|00006150| 6e 6d 61 72 6b 7d 0d 0a | 24 4a 6f 75 72 6e 61 6c |nmark}..|$Journal|
|00006160| 7b 43 6c 69 6e 20 50 68 | 61 72 6d 61 63 6f 6c 20 |{Clin Ph|armacol |
|00006170| 54 68 65 72 7d 0d 0a 24 | 56 6f 6c 75 6d 65 7b 34 |Ther}..$|Volume{4|
|00006180| 37 7d 0d 0a 24 50 61 67 | 65 7b 35 30 39 2d 35 31 |7}..$Pag|e{509-51|
|00006190| 35 7d 0d 0a 24 44 61 74 | 65 7b 31 39 39 30 7d 0d |5}..$Dat|e{1990}.|
|000061a0| 0a 24 59 42 56 6f 6c 7b | 31 39 39 31 20 59 65 61 |.$YBVol{|1991 Yea|
|000061b0| 72 20 42 6f 6f 6b 20 6f | 66 20 44 72 75 67 20 54 |r Book o|f Drug T|
|000061c0| 68 65 72 61 70 79 7d 0d | 0a 24 43 68 61 70 74 65 |herapy}.|.$Chapte|
|000061d0| 72 7b 31 32 2d 36 7d 0d | 0a 24 59 42 45 64 69 74 |r{12-6}.|.$YBEdit|
|000061e0| 6f 72 7b 44 72 73 2e 20 | 4c 61 73 61 67 6e 61 20 |or{Drs. |Lasagna |
|000061f0| 61 6e 64 20 57 65 69 6e | 74 72 61 75 62 7d 0d 0a |and Wein|traub}..|
|00006200| 24 54 61 62 6c 65 7b 7d | 0d 0a 24 43 6f 6d 6d 65 |$Table{}|..$Comme|
|00006210| 6e 74 61 74 6f 72 7b 4c | 2e 20 4c 61 73 61 67 6e |ntator{L|. Lasagn|
|00006220| 61 2c 20 4d 2e 44 2e 7d | 0d 0a 0d 0a 43 6f 70 79 |a, M.D.}|....Copy|
|00006230| 72 69 67 68 74 20 28 43 | 29 20 59 65 61 72 20 42 |right (C|) Year B|
|00006240| 6f 6f 6b 20 4d 65 64 69 | 63 61 6c 20 50 75 62 6c |ook Medi|cal Publ|
|00006250| 69 73 68 65 72 73 2c 20 | 49 6e 63 2e 20 31 39 39 |ishers, |Inc. 199|
|00006260| 31 0d 0a 0d 0a 31 39 39 | 31 20 59 65 61 72 20 42 |1....199|1 Year B|
|00006270| 6f 6f 6b 20 6f 66 20 44 | 72 75 67 20 54 68 65 72 |ook of D|rug Ther|
|00006280| 61 70 79 0d 0a 0d 0a 43 | 68 61 70 74 65 72 20 31 |apy....C|hapter 1|
|00006290| 32 20 2d 2d 20 4e 65 75 | 72 6f 6c 6f 67 69 63 20 |2 -- Neu|rologic |
|000062a0| 44 69 73 65 61 73 65 73 | 0d 0a 0d 0a 2d 2d 2d 2d |Diseases|....----|
|000062b0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000062c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000062d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000062e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000062f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 43 6f 6e 63 |--------|--..Conc|
|00006300| 65 6e 74 72 61 74 69 6f | 6e 2d 52 65 73 70 6f 6e |entratio|n-Respon|
|00006310| 73 65 20 52 65 6c 61 74 | 69 6f 6e 73 68 69 70 20 |se Relat|ionship |
|00006320| 69 6e 20 49 6d 69 70 72 | 61 6d 69 6e 65 20 54 72 |in Imipr|amine Tr|
|00006330| 65 61 74 6d 65 6e 74 20 | 6f 66 20 44 69 61 62 65 |eatment |of Diabe|
|00006340| 74 69 63 0d 0a 4e 65 75 | 72 6f 70 61 74 68 79 20 |tic..Neu|ropathy |
|00006350| 53 79 6d 70 74 6f 6d 73 | 0d 0a 0d 0a 53 69 6e 64 |Symptoms|....Sind|
|00006360| 72 75 70 20 53 48 3b 20 | 47 72 61 6d 20 4c 46 3b |rup SH; |Gram LF;|
|00006370| 20 53 6b 6a 6f 6c 64 20 | 54 3b 20 46 72 6f 6c 61 | Skjold |T; Frola|
|00006380| 6e 64 20 41 3b 20 42 65 | 63 6b 2d 4e 69 65 6c 73 |nd A; Be|ck-Niels|
|00006390| 65 6e 20 48 0d 0a 28 4f | 64 65 6e 73 65 20 55 6e |en H..(O|dense Un|
|000063a0| 69 76 2c 20 4f 64 65 6e | 73 65 2c 20 44 65 6e 6d |iv, Oden|se, Denm|
|000063b0| 61 72 6b 29 0d 0a 43 6c | 69 6e 20 50 68 61 72 6d |ark)..Cl|in Pharm|
|000063c0| 61 63 6f 6c 20 54 68 65 | 72 20 34 37 3a 35 30 39 |acol The|r 47:509|
|000063d0| 2d 35 31 35 2c 20 31 39 | 39 30 0d 0a 2d 2d 2d 2d |-515, 19|90..----|
|000063e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000063f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
+--------+-------------------------+-------------------------+--------+--------+
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