home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-05 | 313.1 KB |
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MacOS 8.1
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Win98
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DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
|00000020| 01 10 00 00 30 31 00 00 | 00 01 9d 15 00 00 68 0a |....01..|......h.|
|00000030| 00 00 30 32 00 00 00 01 | 05 20 00 00 fc 0b 00 00 |..02....|. ......|
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|00000050| 00 00 00 01 6f 39 00 00 | 57 0a 00 00 30 35 00 00 |....o9..|W...05..|
|00000060| 00 01 c6 43 00 00 15 0b | 00 00 30 36 00 00 00 01 |...C....|..06....|
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|00000240| 01 00 cb 0c 00 00 34 30 | 00 00 00 01 4e 09 02 00 |......40|....N...|
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|00000260| 00 00 34 32 00 00 00 01 | 50 27 02 00 69 0f 00 00 |..42....|P'..i...|
|00000270| 34 33 00 00 00 01 b9 36 | 02 00 3c 07 00 00 34 34 |43.....6|..<...44|
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|000002b0| 02 00 5d 0a 00 00 34 38 | 00 00 00 01 8b 64 02 00 |..]...48|.....d..|
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|00000310| ae b1 02 00 8f 0b 00 00 | 35 35 00 00 00 01 3d bd |........|55....=.|
|00000320| 02 00 68 0d 00 00 35 36 | 00 00 00 01 a5 ca 02 00 |..h...56|........|
|00000330| c1 0a 00 00 35 37 00 00 | 00 01 66 d5 02 00 fa 0c |....57..|..f.....|
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|00000350| 35 39 00 00 00 01 74 ee | 02 00 12 0a 00 00 36 30 |59....t.|......60|
|00000360| 00 00 00 01 86 f8 02 00 | 73 07 00 00 36 31 00 00 |........|s...61..|
|00000370| 00 01 f9 ff 02 00 b4 0c | 00 00 36 32 00 00 00 01 |........|..62....|
|00000380| ad 0c 03 00 ac 0a 00 00 | 36 33 00 00 00 01 59 17 |........|63....Y.|
|00000390| 03 00 4a 0c 00 00 36 34 | 00 00 00 01 a3 23 03 00 |..J...64|.....#..|
|000003a0| 2c 0e 00 00 36 35 00 00 | 00 01 cf 31 03 00 a2 09 |,...65..|...1....|
|000003b0| 00 00 36 36 00 00 00 01 | 71 3b 03 00 31 0e 00 00 |..66....|q;..1...|
|000003c0| 36 37 00 00 00 01 a2 49 | 03 00 de 08 00 00 36 38 |67.....I|......68|
|000003d0| 00 00 00 01 80 52 03 00 | 86 0b 00 00 36 39 00 00 |.....R..|....69..|
|000003e0| 00 01 06 5e 03 00 32 09 | 00 00 37 30 00 00 00 01 |...^..2.|..70....|
|000003f0| 38 67 03 00 38 09 00 00 | 37 31 00 00 00 01 70 70 |8g..8...|71....pp|
|00000400| 03 00 7d 0c 00 00 37 32 | 00 00 00 01 ed 7c 03 00 |..}...72|.....|..|
|00000410| 08 13 00 00 37 33 00 00 | 00 01 f5 8f 03 00 ef 09 |....73..|........|
|00000420| 00 00 37 34 00 00 00 01 | e4 99 03 00 c3 08 00 00 |..74....|........|
|00000430| 37 35 00 00 00 01 a7 a2 | 03 00 ec 0a 00 00 37 36 |75......|......76|
|00000440| 00 00 00 01 93 ad 03 00 | f6 0c 00 00 37 37 00 00 |........|....77..|
|00000450| 00 01 89 ba 03 00 6f 09 | 00 00 37 38 00 00 00 01 |......o.|..78....|
|00000460| f8 c3 03 00 bd 0d 00 00 | 37 39 00 00 00 01 b5 d1 |........|79......|
|00000470| 03 00 d8 0c 00 00 38 30 | 00 00 00 01 8d de 03 00 |......80|........|
|00000480| ef 0b 00 00 38 31 00 00 | 00 01 7c ea 03 00 3b 09 |....81..|..|...;.|
|00000490| 00 00 38 32 00 00 00 01 | b7 f3 03 00 c5 0b 00 00 |..82....|........|
|000004a0| 38 33 00 00 00 01 7c ff | 03 00 2d 09 00 00 38 34 |83....|.|..-...84|
|000004b0| 00 00 00 01 a9 08 04 00 | 49 0d 00 00 38 35 00 00 |........|I...85..|
|000004c0| 00 01 f2 15 04 00 a7 1a | 00 00 38 36 00 00 00 01 |........|..86....|
|000004d0| 99 30 04 00 82 08 00 00 | 38 37 00 00 00 01 1b 39 |.0......|87.....9|
|000004e0| 04 00 89 0d 00 00 38 38 | 00 00 00 01 a4 46 04 00 |......88|.....F..|
|000004f0| 7a 07 00 00 38 39 00 00 | 00 01 1e 4e 04 00 92 11 |z...89..|...N....|
|00000500| 00 00 39 30 00 00 00 01 | b0 5f 04 00 12 10 00 00 |..90....|._......|
|00000510| 39 31 00 00 00 01 c2 6f | 04 00 f7 0e 00 00 39 32 |91.....o|......92|
|00000520| 00 00 00 01 b9 7e 04 00 | ec 11 00 00 39 33 00 00 |.....~..|....93..|
|00000530| 00 01 a5 90 04 00 f4 0b | 00 00 39 34 00 00 00 01 |........|..94....|
|00000540| 99 9c 04 00 0c 0c 00 00 | 39 35 00 00 00 01 a5 a8 |........|95......|
|00000550| 04 00 42 0a 00 00 39 36 | 00 00 00 01 e7 b2 04 00 |..B...96|........|
|00000560| 72 0c 00 00 39 37 00 00 | 00 01 59 bf 04 00 2b 0d |r...97..|..Y...+.|
|00000570| 00 00 39 38 00 00 00 01 | 84 cc 04 00 b4 0c 00 00 |..98....|........|
|00000580| 39 39 00 00 00 01 38 d9 | 04 00 25 0b 00 00 00 00 |99....8.|..%.....|
|00000590| 00 00 00 00 5d e4 04 00 | 00 00 00 00 24 55 6e 69 |....]...|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 30 39 30 30 7d |que_ID{Y|RB00900}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 54 68 65 20 45 66 66 |..$Title|{The Eff|
|000005c0| 65 63 74 20 6f 66 20 50 | 6f 74 61 73 73 69 75 6d |ect of P|otassium|
|000005d0| 20 61 6e 64 20 50 6f 74 | 61 73 73 69 75 6d 20 50 | and Pot|assium P|
|000005e0| 6c 75 73 20 4d 61 67 6e | 65 73 69 75 6d 20 53 75 |lus Magn|esium Su|
|000005f0| 70 70 6c 65 6d 65 6e 74 | 61 74 69 6f 6e 20 6f 6e |pplement|ation on|
|00000600| 0d 0a 56 65 6e 74 72 69 | 63 75 6c 61 72 20 45 78 |..Ventri|cular Ex|
|00000610| 74 72 61 73 79 73 74 6f | 6c 65 73 20 69 6e 20 4d |trasysto|les in M|
|00000620| 69 6c 64 20 48 79 70 65 | 72 74 65 6e 73 69 76 65 |ild Hype|rtensive|
|00000630| 73 20 54 72 65 61 74 65 | 64 20 57 69 74 68 0d 0a |s Treate|d With..|
|00000640| 48 79 64 72 6f 63 68 6c | 6f 72 6f 74 68 69 61 7a |Hydrochl|orothiaz|
|00000650| 69 64 65 7d 0d 0a 24 41 | 75 74 68 6f 72 7b 0d 0a |ide}..$A|uthor{..|
|00000660| 4c 75 6d 6d 65 2c 20 4a | 41 4a 0d 0a 4a 6f 75 6e |Lumme, J|AJ..Joun|
|00000670| 65 6c 61 2c 20 41 4a 7d | 0d 0a 24 41 66 66 69 6c |ela, AJ}|..$Affil|
|00000680| 69 61 74 69 6f 6e 7b 4f | 75 6c 75 20 55 6e 69 76 |iation{O|ulu Univ|
|00000690| 20 43 65 6e 74 72 61 6c | 20 48 6f 73 70 2c 20 4f | Central| Hosp, O|
|000006a0| 75 6c 75 2c 20 46 69 6e | 6c 61 6e 64 7d 0d 0a 24 |ulu, Fin|land}..$|
|000006b0| 4a 6f 75 72 6e 61 6c 7b | 49 6e 74 20 4a 20 43 61 |Journal{|Int J Ca|
|000006c0| 72 64 69 6f 6c 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |rdiol}..|$Volume{|
|000006d0| 32 35 7d 0d 0a 24 50 61 | 67 65 7b 39 33 2d 39 38 |25}..$Pa|ge{93-98|
|000006e0| 7d 0d 0a 24 44 61 74 65 | 7b 31 39 38 39 7d 0d 0a |}..$Date|{1989}..|
|000006f0| 24 59 42 56 6f 6c 7b 31 | 39 39 31 20 59 65 61 72 |$YBVol{1|991 Year|
|00000700| 20 42 6f 6f 6b 20 6f 66 | 20 44 72 75 67 20 54 68 | Book of| Drug Th|
|00000710| 65 72 61 70 79 7d 0d 0a | 24 43 68 61 70 74 65 72 |erapy}..|$Chapter|
|00000720| 7b 36 2d 33 37 7d 0d 0a | 24 59 42 45 64 69 74 6f |{6-37}..|$YBEdito|
|00000730| 72 7b 44 72 73 2e 20 4c | 61 73 61 67 6e 61 20 61 |r{Drs. L|asagna a|
|00000740| 6e 64 20 57 65 69 6e 74 | 72 61 75 62 7d 0d 0a 24 |nd Weint|raub}..$|
|00000750| 54 61 62 6c 65 7b 7d 0d | 0a 24 43 6f 6d 6d 65 6e |Table{}.|.$Commen|
|00000760| 74 61 74 6f 72 7b 4c 2e | 20 4c 61 73 61 67 6e 61 |tator{L.| Lasagna|
|00000770| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|00000780| 69 67 68 74 20 28 43 29 | 20 59 65 61 72 20 42 6f |ight (C)| Year Bo|
|00000790| 6f 6b 20 4d 65 64 69 63 | 61 6c 20 50 75 62 6c 69 |ok Medic|al Publi|
|000007a0| 73 68 65 72 73 2c 20 49 | 6e 63 2e 20 31 39 39 31 |shers, I|nc. 1991|
|000007b0| 0d 0a 0d 0a 31 39 39 31 | 20 59 65 61 72 20 42 6f |....1991| Year Bo|
|000007c0| 6f 6b 20 6f 66 20 44 72 | 75 67 20 54 68 65 72 61 |ok of Dr|ug Thera|
|000007d0| 70 79 0d 0a 0d 0a 43 68 | 61 70 74 65 72 20 36 20 |py....Ch|apter 6 |
|000007e0| 2d 2d 20 43 61 72 64 69 | 6f 76 61 73 63 75 6c 61 |-- Cardi|ovascula|
|000007f0| 72 20 44 69 73 65 61 73 | 65 73 0d 0a 0d 0a 2d 2d |r Diseas|es....--|
|00000800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000820| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000830| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000840| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 54 68 |--------|----..Th|
|00000850| 65 20 45 66 66 65 63 74 | 20 6f 66 20 50 6f 74 61 |e Effect| of Pota|
|00000860| 73 73 69 75 6d 20 61 6e | 64 20 50 6f 74 61 73 73 |ssium an|d Potass|
|00000870| 69 75 6d 20 50 6c 75 73 | 20 4d 61 67 6e 65 73 69 |ium Plus| Magnesi|
|00000880| 75 6d 20 53 75 70 70 6c | 65 6d 65 6e 74 61 74 69 |um Suppl|ementati|
|00000890| 6f 6e 20 6f 6e 0d 0a 56 | 65 6e 74 72 69 63 75 6c |on on..V|entricul|
|000008a0| 61 72 20 45 78 74 72 61 | 73 79 73 74 6f 6c 65 73 |ar Extra|systoles|
|000008b0| 20 69 6e 20 4d 69 6c 64 | 20 48 79 70 65 72 74 65 | in Mild| Hyperte|
|000008c0| 6e 73 69 76 65 73 20 54 | 72 65 61 74 65 64 20 57 |nsives T|reated W|
|000008d0| 69 74 68 0d 0a 48 79 64 | 72 6f 63 68 6c 6f 72 6f |ith..Hyd|rochloro|
|000008e0| 74 68 69 61 7a 69 64 65 | 0d 0a 0d 0a 4c 75 6d 6d |thiazide|....Lumm|
|000008f0| 65 20 4a 41 4a 3b 20 4a | 6f 75 6e 65 6c 61 20 41 |e JAJ; J|ounela A|
|00000900| 4a 0d 0a 28 4f 75 6c 75 | 20 55 6e 69 76 20 43 65 |J..(Oulu| Univ Ce|
|00000910| 6e 74 72 61 6c 20 48 6f | 73 70 2c 20 4f 75 6c 75 |ntral Ho|sp, Oulu|
|00000920| 2c 20 46 69 6e 6c 61 6e | 64 29 0d 0a 49 6e 74 20 |, Finlan|d)..Int |
|00000930| 4a 20 43 61 72 64 69 6f | 6c 20 32 35 3a 39 33 2d |J Cardio|l 25:93-|
|00000940| 39 38 2c 20 31 39 38 39 | 0d 0a 2d 2d 2d 2d 2d 2d |98, 1989|..------|
|00000950| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000960| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000970| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000980| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000990| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 41 62 73 74 |--------|....Abst|
|000009a0| 72 61 63 74 0d 0a 0d 0a | 20 20 20 20 20 54 68 65 |ract....| The|
|000009b0| 20 70 6f 73 73 69 62 6c | 65 20 61 6e 74 69 61 72 | possibl|e antiar|
|000009c0| 72 68 79 74 68 6d 69 63 | 20 65 66 66 65 63 74 20 |rhythmic| effect |
|000009d0| 6f 66 20 6f 72 61 6c 20 | 70 6f 74 61 73 73 69 75 |of oral |potassiu|
|000009e0| 6d 20 61 6e 64 20 70 6f | 74 61 73 73 69 75 6d 20 |m and po|tassium |
|000009f0| 70 6c 75 73 0d 0a 6d 61 | 67 6e 65 73 69 75 6d 20 |plus..ma|gnesium |
|00000a00| 73 75 70 70 6c 65 6d 65 | 6e 74 61 74 69 6f 6e 20 |suppleme|ntation |
|00000a10| 77 61 73 20 63 6f 6d 70 | 61 72 65 64 20 69 6e 20 |was comp|ared in |
|00000a20| 31 31 20 6d 69 6c 64 6c | 79 20 68 79 70 65 72 74 |11 mildl|y hypert|
|00000a30| 65 6e 73 69 76 65 20 70 | 61 74 69 65 6e 74 73 20 |ensive p|atients |
|00000a40| 61 67 65 64 0d 0a 33 32 | 2d 36 38 20 79 65 61 72 |aged..32|-68 year|
|00000a50| 73 20 69 6e 20 77 68 6f | 6d 20 61 20 74 65 6e 64 |s in who|m a tend|
|00000a60| 65 6e 63 79 20 66 6f 72 | 20 76 65 6e 74 72 69 63 |ency for| ventric|
|00000a70| 75 6c 61 72 20 65 78 74 | 72 61 73 79 73 74 6f 6c |ular ext|rasystol|
|00000a80| 65 73 20 77 61 73 20 70 | 72 65 73 65 6e 74 0d 0a |es was p|resent..|
|00000a90| 77 69 74 68 6f 75 74 20 | 6f 76 65 72 74 20 63 61 |without |overt ca|
|00000aa0| 72 64 69 61 63 20 64 69 | 73 65 61 73 65 2e 20 20 |rdiac di|sease. |
|00000ab0| 54 68 65 20 64 75 72 61 | 74 69 6f 6e 20 6f 66 20 |The dura|tion of |
|00000ac0| 68 79 70 65 72 74 65 6e | 73 69 6f 6e 20 72 61 6e |hyperten|sion ran|
|00000ad0| 67 65 64 20 66 72 6f 6d | 20 34 0d 0a 6d 6f 6e 74 |ged from| 4..mont|
|00000ae0| 68 73 20 74 6f 20 31 32 | 20 79 65 61 72 73 2e 20 |hs to 12| years. |
|00000af0| 20 41 6c 6c 20 31 31 20 | 70 61 74 69 65 6e 74 73 | All 11 |patients|
|00000b00| 20 65 6e 74 65 72 65 64 | 20 61 20 32 34 2d 77 65 | entered| a 24-we|
|00000b10| 65 6b 20 70 65 72 69 6f | 64 20 6f 66 20 74 72 65 |ek perio|d of tre|
|00000b20| 61 74 6d 65 6e 74 0d 0a | 77 69 74 68 20 35 30 20 |atment..|with 50 |
|00000b30| 6d 67 20 6f 66 20 68 79 | 64 72 6f 63 68 6c 6f 72 |mg of hy|drochlor|
|00000b40| 6f 74 68 69 61 7a 69 64 | 65 20 64 61 69 6c 79 2e |othiazid|e daily.|
|00000b50| 20 20 45 69 67 68 74 20 | 68 61 64 20 62 65 65 6e | Eight |had been|
|00000b60| 20 74 72 65 61 74 65 64 | 20 70 72 65 76 69 6f 75 | treated| previou|
|00000b70| 73 6c 79 0d 0a 77 69 74 | 68 20 35 30 20 6d 67 20 |sly..wit|h 50 mg |
|00000b80| 6f 66 20 68 79 64 72 6f | 63 68 6c 6f 72 6f 74 68 |of hydro|chloroth|
|00000b90| 69 61 7a 69 64 65 20 70 | 6c 75 73 20 35 20 6d 67 |iazide p|lus 5 mg|
|00000ba0| 20 6f 66 20 61 6d 69 6c | 6f 72 69 64 65 2c 20 32 | of amil|oride, 2|
|00000bb0| 20 77 69 74 68 20 35 20 | 6d 67 20 6f 66 0d 0a 74 | with 5 |mg of..t|
|00000bc0| 69 6d 6f 6c 6f 6c 20 64 | 61 69 6c 79 2e 20 20 49 |imolol d|aily. I|
|00000bd0| 73 63 68 65 6d 69 63 20 | 68 65 61 72 74 20 64 69 |schemic |heart di|
|00000be0| 73 65 61 73 65 20 77 61 | 73 20 65 78 63 6c 75 64 |sease wa|s exclud|
|00000bf0| 65 64 2c 20 61 6e 64 20 | 63 68 65 73 74 20 78 2d |ed, and |chest x-|
|00000c00| 72 61 79 20 66 69 6c 6d | 73 20 61 6e 64 0d 0a 45 |ray film|s and..E|
|00000c10| 43 47 73 20 77 65 72 65 | 20 6e 6f 72 6d 61 6c 20 |CGs were| normal |
|00000c20| 69 6e 20 61 6c 6c 20 31 | 31 20 70 61 74 69 65 6e |in all 1|1 patien|
|00000c30| 74 73 2e 20 20 56 65 6e | 74 72 69 63 75 6c 61 72 |ts. Ven|tricular|
|00000c40| 20 65 78 74 72 61 73 79 | 73 74 6f 6c 65 73 20 72 | extrasy|stoles r|
|00000c50| 61 6e 67 65 64 20 66 72 | 6f 6d 20 32 35 0d 0a 74 |anged fr|om 25..t|
|00000c60| 6f 20 38 2c 35 30 30 20 | 69 6e 20 32 34 20 68 6f |o 8,500 |in 24 ho|
|00000c70| 75 72 73 2e 20 20 50 72 | 65 76 69 6f 75 73 20 61 |urs. Pr|evious a|
|00000c80| 6e 74 69 68 79 70 65 72 | 74 65 6e 73 69 76 65 20 |ntihyper|tensive |
|00000c90| 74 68 65 72 61 70 79 20 | 77 61 73 20 64 69 73 63 |therapy |was disc|
|00000ca0| 6f 6e 74 69 6e 75 65 64 | 0d 0a 62 65 66 6f 72 65 |ontinued|..before|
|00000cb0| 20 74 68 65 20 64 69 75 | 72 65 74 69 63 20 74 72 | the diu|retic tr|
|00000cc0| 65 61 74 6d 65 6e 74 20 | 77 61 73 20 73 74 61 72 |eatment |was star|
|00000cd0| 74 65 64 2e 0d 0a 20 20 | 20 20 20 54 68 65 20 70 |ted... | The p|
|00000ce0| 61 74 69 65 6e 74 73 20 | 62 65 67 61 6e 20 74 72 |atients |began tr|
|00000cf0| 65 61 74 6d 65 6e 74 20 | 77 69 74 68 20 68 79 64 |eatment |with hyd|
|00000d00| 72 6f 63 68 6c 6f 72 6f | 74 68 69 61 7a 69 64 65 |rochloro|thiazide|
|00000d10| 2c 20 35 30 20 6d 67 2f | 64 61 79 2c 20 77 68 69 |, 50 mg/|day, whi|
|00000d20| 63 68 0d 0a 77 61 73 20 | 63 6f 6e 74 69 6e 75 65 |ch..was |continue|
|00000d30| 64 20 74 68 72 6f 75 67 | 68 6f 75 74 20 74 68 65 |d throug|hout the|
|00000d40| 20 73 74 75 64 79 2e 20 | 20 41 66 74 65 72 20 38 | study. | After 8|
|00000d50| 20 77 65 65 6b 73 20 6f | 66 20 74 72 65 61 74 6d | weeks o|f treatm|
|00000d60| 65 6e 74 20 65 69 74 68 | 65 72 20 31 20 67 20 6f |ent eith|er 1 g o|
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|00000d80| 68 79 64 72 6f 63 68 6c | 6f 72 69 64 65 2c 20 74 |hydrochl|oride, t|
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|00002a10| 61 77 61 6c 20 6f 66 20 | 62 65 74 61 2d 62 6c 6f |awal of |beta-blo|
|00002a20| 63 6b 65 72 73 20 6d 61 | 79 20 62 65 20 61 6e 20 |ckers ma|y be an |
|00002a30| 61 63 75 74 65 20 70 72 | 65 63 69 70 69 74 61 6e |acute pr|ecipitan|
|00002a40| 74 20 6f 66 20 61 6e 67 | 69 6e 61 20 61 6e 64 0d |t of ang|ina and.|
|00002a50| 0a 6d 79 6f 63 61 72 64 | 69 61 6c 20 69 6e 66 61 |.myocard|ial infa|
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|00002a80| 77 69 74 68 20 6e 6f 20 | 68 69 73 74 6f 72 79 20 |with no |history |
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|00002ab0| 6f 73 74 2d 43 6f 6d 6d | 65 6e 74 0d 0a 0d 0a 20 |ost-Comm|ent.... |
|00002ac0| 20 20 20 20 48 65 72 65 | 27 73 20 61 6e 6f 74 68 | Here|'s anoth|
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|00002ae0| 65 20 72 69 73 6b 73 20 | 6f 66 20 73 74 6f 70 70 |e risks |of stopp|
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|00002b00| 20 74 72 65 61 74 6d 65 | 6e 74 2e 0d 0a 49 66 20 | treatme|nt...If |
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|00002b50| 62 6c 6f 63 6b 65 72 73 | 0d 0a 77 68 6f 20 61 72 |blockers|..who ar|
|00002b60| 65 20 70 6f 6f 72 6c 79 | 20 63 6f 6d 70 6c 69 61 |e poorly| complia|
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|00002b80| 20 70 69 6c 6c 73 20 6f | 6e 20 73 6f 6d 65 20 64 | pills o|n some d|
|00002b90| 61 79 73 20 62 75 74 20 | 6e 6f 74 20 6f 6e 20 6f |ays but |not on o|
|00002ba0| 74 68 65 72 73 3f 0d 0a | 4d 69 67 68 74 20 73 75 |thers?..|Might su|
|00002bb0| 63 68 20 61 20 70 68 65 | 6e 6f 6d 65 6e 6f 6e 20 |ch a phe|nomenon |
|00002bc0| 6e 6f 74 20 63 6f 6e 66 | 6f 75 6e 64 20 74 68 65 |not conf|ound the|
|00002bd0| 20 72 65 73 75 6c 74 73 | 20 6f 66 20 63 6c 69 6e | results| of clin|
|00002be0| 69 63 61 6c 20 74 72 69 | 61 6c 73 3f 2d 2d 4c 2e |ical tri|als?--L.|
|00002bf0| 0d 0a 4c 61 73 61 67 6e | 61 2c 20 4d 2e 44 2e 0d |..Lasagn|a, M.D..|
|00002c00| 0a 24 55 6e 69 71 75 65 | 5f 49 44 7b 59 52 42 30 |.$Unique|_ID{YRB0|
|00002c10| 30 39 30 33 7d 0d 0a 24 | 54 69 74 6c 65 7b 54 72 |0903}..$|Title{Tr|
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|00002cb0| 61 62 6c 65 7d 0d 0a 24 | 41 75 74 68 6f 72 7b 0d |able}..$|Author{.|
|00002cc0| 0a 4d 6f 72 67 61 6e 72 | 6f 74 68 2c 20 4a 0d 0a |.Morganr|oth, J..|
|00002cd0| 42 69 67 67 65 72 2c 20 | 4a 54 2c 20 4a 72 0d 0a |Bigger, |JT, Jr..|
|00002ce0| 41 6e 64 65 72 73 6f 6e | 2c 20 4a 4c 7d 0d 0a 24 |Anderson|, JL}..$|
|00002cf0| 41 66 66 69 6c 69 61 74 | 69 6f 6e 7b 55 6e 69 76 |Affiliat|ion{Univ|
|00002d00| 20 6f 66 20 50 65 6e 6e | 73 79 6c 76 61 6e 69 61 | of Penn|sylvania|
|00002d10| 3b 20 43 6f 6c 75 6d 62 | 69 61 20 55 6e 69 76 3b |; Columb|ia Univ;|
|00002d20| 20 55 6e 69 76 20 6f 66 | 20 55 74 61 68 7d 0d 0a | Univ of| Utah}..|
|00002d30| 24 4a 6f 75 72 6e 61 6c | 7b 41 6d 20 4a 20 43 61 |$Journal|{Am J Ca|
|00002d40| 72 64 69 6f 6c 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |rdiol}..|$Volume{|
|00002d50| 36 35 7d 0d 0a 24 50 61 | 67 65 7b 34 30 2d 34 38 |65}..$Pa|ge{40-48|
|00002d60| 7d 0d 0a 24 44 61 74 65 | 7b 31 39 39 30 7d 0d 0a |}..$Date|{1990}..|
|00002d70| 24 59 42 56 6f 6c 7b 31 | 39 39 31 20 59 65 61 72 |$YBVol{1|991 Year|
|00002d80| 20 42 6f 6f 6b 20 6f 66 | 20 44 72 75 67 20 54 68 | Book of| Drug Th|
|00002d90| 65 72 61 70 79 7d 0d 0a | 24 43 68 61 70 74 65 72 |erapy}..|$Chapter|
|00002da0| 7b 36 2d 34 30 7d 0d 0a | 24 59 42 45 64 69 74 6f |{6-40}..|$YBEdito|
|00002db0| 72 7b 44 72 73 2e 20 4c | 61 73 61 67 6e 61 20 61 |r{Drs. L|asagna a|
|00002dc0| 6e 64 20 57 65 69 6e 74 | 72 61 75 62 7d 0d 0a 24 |nd Weint|raub}..$|
|00002dd0| 54 61 62 6c 65 7b 54 61 | 62 6c 65 20 4f 6d 69 74 |Table{Ta|ble Omit|
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|00002df0| 6f 72 7b 4c 2e 20 4c 61 | 73 61 67 6e 61 2c 20 4d |or{L. La|sagna, M|
|00002e00| 2e 44 2e 7d 0d 0a 0d 0a | 43 6f 70 79 72 69 67 68 |.D.}....|Copyrigh|
|00002e10| 74 20 28 43 29 20 59 65 | 61 72 20 42 6f 6f 6b 20 |t (C) Ye|ar Book |
|00002e20| 4d 65 64 69 63 61 6c 20 | 50 75 62 6c 69 73 68 65 |Medical |Publishe|
|00002e30| 72 73 2c 20 49 6e 63 2e | 20 31 39 39 31 0d 0a 0d |rs, Inc.| 1991...|
|00002e40| 0a 31 39 39 31 20 59 65 | 61 72 20 42 6f 6f 6b 20 |.1991 Ye|ar Book |
|00002e50| 6f 66 20 44 72 75 67 20 | 54 68 65 72 61 70 79 0d |of Drug |Therapy.|
|00002e60| 0a 0d 0a 43 68 61 70 74 | 65 72 20 36 20 2d 2d 20 |...Chapt|er 6 -- |
|00002e70| 43 61 72 64 69 6f 76 61 | 73 63 75 6c 61 72 20 44 |Cardiova|scular D|
|00002e80| 69 73 65 61 73 65 73 0d | 0a 0d 0a 2d 2d 2d 2d 2d |iseases.|...-----|
|00002e90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ea0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002eb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ec0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002ed0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 0d 0a 54 72 65 61 74 |--------|-..Treat|
|00002ee0| 6d 65 6e 74 20 6f 66 20 | 56 65 6e 74 72 69 63 75 |ment of |Ventricu|
|00002ef0| 6c 61 72 20 41 72 72 68 | 79 74 68 6d 69 61 73 20 |lar Arrh|ythmias |
|00002f00| 62 79 20 55 6e 69 74 65 | 64 20 53 74 61 74 65 73 |by Unite|d States|
|00002f10| 20 43 61 72 64 69 6f 6c | 6f 67 69 73 74 73 3a 20 | Cardiol|ogists: |
|00002f20| 20 41 20 53 75 72 76 65 | 79 0d 0a 42 65 66 6f 72 | A Surve|y..Befor|
|00002f30| 65 20 74 68 65 20 43 61 | 72 64 69 61 63 20 41 72 |e the Ca|rdiac Ar|
|00002f40| 72 68 79 74 68 6d 69 61 | 20 53 75 70 70 72 65 73 |rhythmia| Suppres|
|00002f50| 73 69 6f 6e 20 54 72 69 | 61 6c 20 52 65 73 75 6c |sion Tri|al Resul|
|00002f60| 74 73 20 57 65 72 65 20 | 41 76 61 69 6c 61 62 6c |ts Were |Availabl|
|00002f70| 65 0d 0a 0d 0a 4d 6f 72 | 67 61 6e 72 6f 74 68 20 |e....Mor|ganroth |
|00002f80| 4a 3b 20 42 69 67 67 65 | 72 20 4a 54 20 4a 72 3b |J; Bigge|r JT Jr;|
|00002f90| 20 41 6e 64 65 72 73 6f | 6e 20 4a 4c 0d 0a 28 55 | Anderso|n JL..(U|
|00002fa0| 6e 69 76 20 6f 66 20 50 | 65 6e 6e 73 79 6c 76 61 |niv of P|ennsylva|
|00002fb0| 6e 69 61 3b 20 43 6f 6c | 75 6d 62 69 61 20 55 6e |nia; Col|umbia Un|
|00002fc0| 69 76 3b 20 55 6e 69 76 | 20 6f 66 20 55 74 61 68 |iv; Univ| of Utah|
|00002fd0| 29 0d 0a 41 6d 20 4a 20 | 43 61 72 64 69 6f 6c 20 |)..Am J |Cardiol |
|00002fe0| 36 35 3a 34 30 2d 34 38 | 2c 20 31 39 39 30 0d 0a |65:40-48|, 1990..|
|00002ff0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003000| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003010| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003020| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003030| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 0d 0a |--------|------..|
|00003040| 0d 0a 41 62 73 74 72 61 | 63 74 0d 0a 0d 0a 20 20 |..Abstra|ct.... |
|00003050| 20 20 20 54 68 65 20 6d | 61 6e 61 67 65 6d 65 6e | The m|anagemen|
|00003060| 74 20 6f 66 20 70 6f 74 | 65 6e 74 69 61 6c 6c 79 |t of pot|entially|
|00003070| 20 6d 61 6c 69 67 6e 61 | 6e 74 20 76 65 6e 74 72 | maligna|nt ventr|
|00003080| 69 63 75 6c 61 72 20 61 | 72 72 68 79 74 68 6d 69 |icular a|rrhythmi|
|00003090| 61 73 20 72 65 6d 61 69 | 6e 73 0d 0a 63 6f 6e 74 |as remai|ns..cont|
|000030a0| 72 6f 76 65 72 73 69 61 | 6c 2e 20 20 54 68 65 20 |roversia|l. The |
|000030b0| 70 72 61 63 74 69 63 65 | 20 6f 66 20 31 2c 30 30 |practice| of 1,00|
|000030c0| 30 20 72 61 6e 64 6f 6d | 6c 79 20 73 65 6c 65 63 |0 random|ly selec|
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|000030e0| 73 0d 0a 63 61 72 64 69 | 6f 6c 6f 67 69 73 74 73 |s..cardi|ologists|
|000030f0| 20 77 61 73 20 6d 65 61 | 73 75 72 65 64 20 62 79 | was mea|sured by|
|00003100| 20 73 75 72 76 65 79 20 | 62 65 66 6f 72 65 20 74 | survey |before t|
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|00003160| 54 29 2e 0d 0a 20 20 20 | 20 20 4f 66 20 74 68 65 |T)... | Of the|
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|000031a0| 68 65 20 75 73 65 20 6f | 66 0d 0a 61 6e 74 69 61 |he use o|f..antia|
|000031b0| 72 72 68 79 74 68 6d 69 | 63 20 64 72 75 67 20 74 |rrhythmi|c drug t|
|000031c0| 68 65 72 61 70 79 20 66 | 6f 72 20 70 61 74 69 65 |herapy f|or patie|
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|00003200| 20 62 79 20 73 65 76 65 | 72 69 74 79 20 6f 66 20 | by seve|rity of |
|00003210| 63 61 72 64 69 61 63 20 | 64 69 73 65 61 73 65 2c |cardiac |disease,|
|00003220| 20 70 72 65 73 65 6e 63 | 65 20 6f 66 20 73 79 6d | presenc|e of sym|
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|00003240| 6f 66 0d 0a 76 65 6e 74 | 72 69 63 75 6c 61 72 20 |of..vent|ricular |
|00003250| 61 72 72 68 79 74 68 6d | 69 61 73 2e 20 20 4f 6e |arrhythm|ias. On|
|00003260| 6c 79 20 31 25 20 6f 66 | 20 63 61 72 64 69 6f 6c |ly 1% of| cardiol|
|00003270| 6f 67 69 73 74 73 20 74 | 72 65 61 74 65 64 20 61 |ogists t|reated a|
|00003280| 73 79 6d 70 74 6f 6d 61 | 74 69 63 0d 0a 76 65 6e |symptoma|tic..ven|
|00003290| 74 72 69 63 75 6c 61 72 | 20 70 72 65 6d 61 74 75 |tricular| prematu|
|000032a0| 72 65 20 63 6f 6d 70 6c | 65 78 65 73 20 77 69 74 |re compl|exes wit|
|000032b0| 68 6f 75 74 20 68 65 61 | 72 74 20 64 69 73 65 61 |hout hea|rt disea|
|000032c0| 73 65 2c 20 62 75 74 20 | 31 37 25 20 74 72 65 61 |se, but |17% trea|
|000032d0| 74 65 64 20 74 68 65 6d | 20 69 66 0d 0a 75 6e 73 |ted them| if..uns|
|000032e0| 75 73 74 61 69 6e 65 64 | 20 76 65 6e 74 72 69 63 |ustained| ventric|
|000032f0| 75 6c 61 72 20 74 61 63 | 68 79 63 61 72 64 69 61 |ular tac|hycardia|
|00003300| 20 77 61 73 20 70 72 65 | 73 65 6e 74 2e 20 20 57 | was pre|sent. W|
|00003310| 68 65 6e 20 63 6f 72 6f | 6e 61 72 79 20 61 72 74 |hen coro|nary art|
|00003320| 65 72 79 20 64 69 73 65 | 61 73 65 0d 0a 77 61 73 |ery dise|ase..was|
|00003330| 20 70 72 65 73 65 6e 74 | 2c 20 74 68 65 20 74 72 | present|, the tr|
|00003340| 65 61 74 6d 65 6e 74 20 | 72 61 74 65 20 69 6e 63 |eatment |rate inc|
|00003350| 72 65 61 73 65 64 20 74 | 6f 20 33 38 25 2e 20 20 |reased t|o 38%. |
|00003360| 54 68 65 20 70 72 65 73 | 65 6e 63 65 20 6f 66 20 |The pres|ence of |
|00003370| 63 61 72 64 69 61 63 0d | 0a 64 69 73 65 61 73 65 |cardiac.|.disease|
|00003380| 20 61 6e 64 20 73 79 6d | 70 74 6f 6d 61 74 69 63 | and sym|ptomatic|
|00003390| 20 61 72 72 68 79 74 68 | 6d 69 61 73 20 69 6e 63 | arrhyth|mias inc|
|000033a0| 72 65 61 73 65 64 20 74 | 68 65 20 74 72 65 61 74 |reased t|he treat|
|000033b0| 6d 65 6e 74 20 72 61 74 | 65 20 74 6f 20 31 30 30 |ment rat|e to 100|
|000033c0| 25 2e 0d 0a 62 65 74 61 | 2d 42 6c 6f 63 6b 65 72 |%...beta|-Blocker|
|000033d0| 73 20 77 65 72 65 20 74 | 68 65 20 6d 6f 73 74 20 |s were t|he most |
|000033e0| 63 6f 6d 6d 6f 6e 20 69 | 6e 69 74 69 61 6c 20 74 |common i|nitial t|
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|00003400| 2e 20 20 4e 6f 6e 65 20 | 6f 66 20 74 68 65 0d 0a |. None |of the..|
|00003410| 63 61 72 64 69 6f 6c 6f | 67 69 73 74 73 20 77 6f |cardiolo|gists wo|
|00003420| 75 6c 64 20 75 73 65 20 | 61 6d 69 6f 64 61 72 6f |uld use |amiodaro|
|00003430| 6e 65 20 69 6e 20 6e 65 | 77 20 70 61 74 69 65 6e |ne in ne|w patien|
|00003440| 74 73 2c 20 62 75 74 20 | 33 33 25 20 77 6f 75 6c |ts, but |33% woul|
|00003450| 64 20 75 73 65 0d 0a 61 | 6d 69 6f 64 61 72 6f 6e |d use..a|miodaron|
|00003460| 65 20 66 6f 72 20 72 65 | 66 72 61 63 74 6f 72 79 |e for re|fractory|
|00003470| 20 70 61 74 69 65 6e 74 | 73 20 77 69 74 68 20 70 | patient|s with p|
|00003480| 6f 74 65 6e 74 69 61 6c | 6c 79 20 6d 61 6c 69 67 |otential|ly malig|
|00003490| 6e 61 6e 74 20 76 65 6e | 74 72 69 63 75 6c 61 72 |nant ven|tricular|
|000034a0| 0d 0a 61 72 72 68 79 74 | 68 6d 69 61 73 20 28 54 |..arrhyt|hmias (T|
|000034b0| 61 62 6c 65 20 32 29 2e | 20 20 54 68 65 20 6c 61 |able 2).| The la|
|000034c0| 74 74 65 72 20 75 73 65 | 20 69 73 20 63 6f 6e 74 |tter use| is cont|
|000034d0| 72 61 69 6e 64 69 63 61 | 74 65 64 20 69 6e 20 74 |raindica|ted in t|
|000034e0| 68 65 20 6c 61 62 65 6c | 69 6e 67 20 6f 66 0d 0a |he label|ing of..|
|000034f0| 74 68 69 73 20 64 72 75 | 67 2e 0d 0a 20 20 20 20 |this dru|g... |
|00003500| 20 54 68 65 20 68 69 67 | 68 20 70 6f 74 65 6e 74 | The hig|h potent|
|00003510| 69 61 6c 20 66 6f 72 20 | 6f 72 67 61 6e 20 74 6f |ial for |organ to|
|00003520| 78 69 63 69 74 79 20 6f | 66 20 71 75 69 6e 69 64 |xicity o|f quinid|
|00003530| 69 6e 65 2c 20 70 72 6f | 63 61 69 6e 61 6d 69 64 |ine, pro|cainamid|
|00003540| 65 2c 20 61 6e 64 0d 0a | 74 6f 63 61 69 6e 69 64 |e, and..|tocainid|
|00003550| 65 20 77 61 73 20 6e 6f | 74 20 72 65 63 6f 67 6e |e was no|t recogn|
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|00003570| 72 69 74 79 20 6f 66 20 | 63 61 72 64 69 6f 6c 6f |rity of |cardiolo|
|00003580| 67 69 73 74 73 20 28 54 | 61 62 6c 65 20 33 29 2e |gists (T|able 3).|
|00003590| 0d 0a 43 61 72 64 69 6f | 6c 6f 67 69 73 74 73 20 |..Cardio|logists |
|000035a0| 62 65 6c 69 65 76 65 64 | 20 74 68 61 74 20 61 6e |believed| that an|
|000035b0| 74 69 61 72 72 68 79 74 | 68 6d 69 63 20 64 72 75 |tiarrhyt|hmic dru|
|000035c0| 67 73 20 77 69 74 68 20 | 63 6c 61 73 73 20 49 41 |gs with |class IA|
|000035d0| 20 61 6e 64 20 49 43 20 | 61 63 74 69 6f 6e 0d 0a | and IC |action..|
|000035e0| 77 65 72 65 20 65 71 75 | 61 6c 6c 79 20 70 6f 74 |were equ|ally pot|
|000035f0| 65 6e 74 20 69 6e 20 74 | 68 69 73 20 70 61 74 69 |ent in t|his pati|
|00003600| 65 6e 74 20 67 72 6f 75 | 70 2e 20 20 41 6e 74 69 |ent grou|p. Anti|
|00003610| 61 72 72 68 79 74 68 6d | 69 63 20 64 72 75 67 73 |arrhythm|ic drugs|
|00003620| 20 77 65 72 65 0d 0a 69 | 6e 69 74 69 61 74 65 64 | were..i|nitiated|
|00003630| 20 65 78 63 6c 75 73 69 | 76 65 6c 79 20 69 6e 20 | exclusi|vely in |
|00003640| 74 68 65 20 68 6f 73 70 | 69 74 61 6c 20 62 79 20 |the hosp|ital by |
|00003650| 32 35 25 20 6f 66 20 63 | 61 72 64 69 6f 6c 6f 67 |25% of c|ardiolog|
|00003660| 69 73 74 73 2e 0d 0a 45 | 6c 65 63 74 72 6f 70 68 |ists...E|lectroph|
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|00005080| 73 2c 20 49 6e 63 2e 20 | 31 39 39 31 0d 0a 0d 0a |s, Inc. |1991....|
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|000050b0| 0d 0a 43 68 61 70 74 65 | 72 20 36 20 2d 2d 20 43 |..Chapte|r 6 -- C|
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|00005140| 6d 69 61 3a 20 20 41 20 | 43 6f 6d 70 6c 69 63 61 |mia: A |Complica|
|00005150| 74 69 6f 6e 20 6f 66 20 | 41 6e 74 69 61 72 72 68 |tion of |Antiarrh|
|00005160| 79 74 68 6d 69 63 20 44 | 72 75 67 20 54 68 65 72 |ythmic D|rug Ther|
|00005170| 61 70 79 0d 0a 0d 0a 50 | 6f 64 72 69 64 20 50 4a |apy....P|odrid PJ|
|00005180| 0d 0a 28 42 6f 73 74 6f | 6e 20 55 6e 69 76 29 0d |..(Bosto|n Univ).|
|00005190| 0a 45 75 72 20 48 65 61 | 72 74 20 4a 20 31 30 28 |.Eur Hea|rt J 10(|
|000051a0| 73 75 70 70 6c 20 45 29 | 3a 36 36 2d 37 32 2c 20 |suppl E)|:66-72, |
|000051b0| 31 39 38 39 0d 0a 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |1989..--|--------|
|000051c0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000051d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000051e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000051f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005200| 2d 2d 2d 2d 0d 0a 0d 0a | 41 62 73 74 72 61 63 74 |----....|Abstract|
|00005210| 0d 0a 0d 0a 20 20 20 20 | 20 4f 6e 65 20 73 65 72 |.... | One ser|
|00005220| 69 6f 75 73 20 73 69 64 | 65 20 65 66 66 65 63 74 |ious sid|e effect|
|00005230| 20 6f 66 20 61 6e 74 69 | 61 72 72 68 79 74 68 6d | of anti|arrhythm|
|00005240| 69 63 20 64 72 75 67 73 | 20 69 73 20 61 67 67 72 |ic drugs| is aggr|
|00005250| 61 76 61 74 69 6f 6e 20 | 6f 66 0d 0a 61 72 72 68 |avation |of..arrh|
|00005260| 79 74 68 6d 69 61 2e 20 | 20 54 68 69 73 20 69 73 |ythmia. | This is|
|00005270| 20 64 65 66 69 6e 65 64 | 20 6e 6f 6e 69 6e 76 61 | defined| noninva|
|00005280| 73 69 76 65 6c 79 20 61 | 73 20 61 20 66 6f 75 72 |sively a|s a four|
|00005290| 66 6f 6c 64 20 69 6e 63 | 72 65 61 73 65 20 69 6e |fold inc|rease in|
|000052a0| 20 74 68 65 0d 0a 66 72 | 65 71 75 65 6e 63 79 20 | the..fr|equency |
|000052b0| 6f 66 20 76 65 6e 74 72 | 69 63 75 6c 61 72 20 70 |of ventr|icular p|
|000052c0| 72 65 6d 61 74 75 72 65 | 20 62 65 61 74 73 20 28 |remature| beats (|
|000052d0| 56 50 42 73 29 2c 20 61 | 20 74 65 6e 66 6f 6c 64 |VPBs), a| tenfold|
|000052e0| 20 69 6e 63 72 65 61 73 | 65 20 69 6e 20 74 68 65 | increas|e in the|
|000052f0| 0d 0a 6e 75 6d 62 65 72 | 20 6f 66 20 72 65 70 65 |..number| of repe|
|00005300| 74 69 74 69 76 65 20 66 | 6f 72 6d 73 2c 20 6f 72 |titive f|orms, or|
|00005310| 20 74 68 65 20 66 69 72 | 73 74 20 6f 63 63 75 72 | the fir|st occur|
|00005320| 72 65 6e 63 65 20 6f 66 | 20 73 75 73 74 61 69 6e |rence of| sustain|
|00005330| 65 64 20 76 65 6e 74 72 | 69 63 75 6c 61 72 0d 0a |ed ventr|icular..|
|00005340| 74 61 63 68 79 61 72 72 | 68 79 74 68 6d 69 61 20 |tachyarr|hythmia |
|00005350| 73 68 6f 72 74 6c 79 20 | 61 66 74 65 72 20 61 64 |shortly |after ad|
|00005360| 6d 69 6e 69 73 74 72 61 | 74 69 6f 6e 20 6f 66 20 |ministra|tion of |
|00005370| 74 68 65 20 61 6e 74 69 | 61 72 72 68 79 74 68 6d |the anti|arrhythm|
|00005380| 69 63 20 64 72 75 67 2e | 0d 0a 41 64 64 69 74 69 |ic drug.|..Additi|
|00005390| 6f 6e 61 6c 20 63 72 69 | 74 65 72 69 61 20 69 6e |onal cri|teria in|
|000053a0| 63 6c 75 64 65 20 61 20 | 6e 65 77 20 74 61 63 68 |clude a |new tach|
|000053b0| 79 61 72 72 68 79 74 68 | 6d 69 61 2c 20 61 20 64 |yarrhyth|mia, a d|
|000053c0| 69 66 66 69 63 75 6c 74 | 20 61 72 72 68 79 74 68 |ifficult| arrhyth|
|000053d0| 6d 69 61 2c 20 61 6e 0d | 0a 75 6e 73 74 61 62 6c |mia, an.|.unstabl|
|000053e0| 65 20 61 72 72 68 79 74 | 68 6d 69 61 2c 20 6d 6f |e arrhyt|hmia, mo|
|000053f0| 72 65 20 66 72 65 71 75 | 65 6e 74 20 65 70 69 73 |re frequ|ent epis|
|00005400| 6f 64 65 73 2c 20 61 6e | 64 20 65 70 69 73 6f 64 |odes, an|d episod|
|00005410| 65 73 20 6f 66 20 6c 6f | 6e 67 65 72 20 64 75 72 |es of lo|nger dur|
|00005420| 61 74 69 6f 6e 2e 0d 0a | 44 75 72 69 6e 67 20 65 |ation...|During e|
|00005430| 6c 65 63 74 72 6f 70 68 | 79 73 69 6f 6c 6f 67 69 |lectroph|ysiologi|
|00005440| 63 20 74 65 73 74 69 6e | 67 2c 20 63 72 69 74 65 |c testin|g, crite|
|00005450| 72 69 61 20 69 6e 63 6c | 75 64 65 20 6d 6f 72 65 |ria incl|ude more|
|00005460| 20 70 72 6f 76 6f 63 61 | 62 6c 65 0d 0a 61 72 72 | provoca|ble..arr|
|00005470| 68 79 74 68 6d 69 61 2c | 20 63 6f 6e 76 65 72 73 |hythmia,| convers|
|00005480| 69 6f 6e 20 66 72 6f 6d | 20 6e 6f 6e 2d 20 74 6f |ion from| non- to|
|00005490| 20 73 75 73 74 61 69 6e | 65 64 20 76 65 6e 74 72 | sustain|ed ventr|
|000054a0| 69 63 75 6c 61 72 20 74 | 61 63 68 79 61 72 72 68 |icular t|achyarrh|
|000054b0| 79 74 68 6d 69 61 2c 0d | 0a 61 72 72 68 79 74 68 |ythmia,.|.arrhyth|
|000054c0| 6d 69 61 20 77 69 74 68 | 20 61 20 66 61 73 74 65 |mia with| a faste|
|000054d0| 72 20 72 61 74 65 2c 20 | 6f 72 20 61 72 72 68 79 |r rate, |or arrhy|
|000054e0| 74 68 6d 69 61 20 74 68 | 61 74 20 69 73 20 64 69 |thmia th|at is di|
|000054f0| 66 66 69 63 75 6c 74 20 | 74 6f 20 74 65 72 6d 69 |fficult |to termi|
|00005500| 6e 61 74 65 2e 0d 0a 20 | 20 20 20 20 56 61 72 69 |nate... | Vari|
|00005510| 6f 75 73 20 73 74 75 64 | 69 65 73 20 68 61 76 65 |ous stud|ies have|
|00005520| 20 6e 6f 6e 69 6e 76 61 | 73 69 76 65 6c 79 20 65 | noninva|sively e|
|00005530| 73 74 69 6d 61 74 65 64 | 20 74 68 65 20 66 72 65 |stimated| the fre|
|00005540| 71 75 65 6e 63 79 20 6f | 66 20 74 68 69 73 0d 0a |quency o|f this..|
|00005550| 63 6f 6d 70 6c 69 63 61 | 74 69 6f 6e 20 61 74 20 |complica|tion at |
|00005560| 61 70 70 72 6f 78 69 6d | 61 74 65 6c 79 20 31 30 |approxim|ately 10|
|00005570| 25 20 6f 66 20 70 61 74 | 69 65 6e 74 73 2e 20 20 |% of pat|ients. |
|00005580| 54 68 65 20 61 67 67 72 | 61 76 61 74 69 6f 6e 20 |The aggr|avation |
|00005590| 6f 62 73 65 72 76 65 64 | 0d 0a 63 6f 6e 73 69 73 |observed|..consis|
|000055a0| 74 65 64 20 6f 66 20 69 | 6e 63 72 65 61 73 65 64 |ted of i|ncreased|
|000055b0| 20 56 50 42 73 20 69 6e | 20 35 25 2c 20 69 6e 63 | VPBs in| 5%, inc|
|000055c0| 72 65 61 73 65 20 69 6e | 20 72 65 70 65 74 69 74 |rease in| repetit|
|000055d0| 69 76 65 20 66 6f 72 6d | 73 20 69 6e 20 33 30 25 |ive form|s in 30%|
|000055e0| 2c 20 61 6e 64 0d 0a 6e | 65 77 20 74 61 63 68 79 |, and..n|ew tachy|
|000055f0| 61 72 72 68 79 74 68 6d | 69 61 20 69 6e 20 36 35 |arrhythm|ia in 65|
|00005600| 25 20 28 46 69 67 20 36 | 2d 36 29 2e 20 20 57 68 |% (Fig 6|-6). Wh|
|00005610| 65 6e 20 69 6e 76 61 73 | 69 76 65 20 6d 65 74 68 |en invas|ive meth|
|00005620| 6f 64 73 20 77 65 72 65 | 20 75 73 65 64 20 74 6f |ods were| used to|
|00005630| 0d 0a 69 6e 76 65 73 74 | 69 67 61 74 65 20 69 6e |..invest|igate in|
|00005640| 63 69 64 65 6e 63 65 2c | 20 74 68 65 20 6f 76 65 |cidence,| the ove|
|00005650| 72 61 6c 6c 20 66 72 65 | 71 75 65 6e 63 79 20 77 |rall fre|quency w|
|00005660| 61 73 20 65 73 74 69 6d | 61 74 65 64 20 61 74 20 |as estim|ated at |
|00005670| 31 38 25 2e 20 20 53 65 | 76 65 72 61 6c 0d 0a 73 |18%. Se|veral..s|
|00005680| 74 75 64 69 65 73 20 68 | 61 76 65 20 69 6e 64 69 |tudies h|ave indi|
|00005690| 63 61 74 65 64 20 74 68 | 61 74 20 74 68 65 20 70 |cated th|at the p|
|000056a0| 61 74 69 65 6e 74 73 20 | 61 74 20 72 69 73 6b 20 |atients |at risk |
|000056b0| 66 6f 72 20 61 67 67 72 | 61 76 61 74 65 64 20 61 |for aggr|avated a|
|000056c0| 72 72 68 79 74 68 6d 69 | 61 0d 0a 68 61 76 65 20 |rrhythmi|a..have |
|000056d0| 61 20 68 69 73 74 6f 72 | 79 20 6f 66 20 73 75 73 |a histor|y of sus|
|000056e0| 74 61 69 6e 65 64 20 74 | 61 63 68 79 61 72 72 68 |tained t|achyarrh|
|000056f0| 79 74 68 6d 69 61 20 61 | 6e 64 20 68 61 76 65 20 |ythmia a|nd have |
|00005700| 72 65 64 75 63 65 64 20 | 6c 65 66 74 20 76 65 6e |reduced |left ven|
|00005710| 74 72 69 63 75 6c 61 72 | 0d 0a 66 75 6e 63 74 69 |tricular|..functi|
|00005720| 6f 6e 3b 20 74 68 65 73 | 65 20 70 61 74 69 65 6e |on; thes|e patien|
|00005730| 74 73 20 6e 65 65 64 20 | 74 68 65 72 61 70 79 20 |ts need |therapy |
|00005740| 74 68 65 20 6d 6f 73 74 | 2e 20 20 41 67 67 72 61 |the most|. Aggra|
|00005750| 76 61 74 69 6f 6e 20 77 | 69 74 68 20 31 20 64 72 |vation w|ith 1 dr|
|00005760| 75 67 20 64 6f 65 73 0d | 0a 6e 6f 74 20 61 70 70 |ug does.|.not app|
|00005770| 65 61 72 20 74 6f 20 70 | 72 65 64 69 63 74 20 61 |ear to p|redict a|
|00005780| 67 67 72 61 76 61 74 69 | 6f 6e 20 77 69 74 68 20 |ggravati|on with |
|00005790| 6f 74 68 65 72 20 64 72 | 75 67 73 2c 20 65 76 65 |other dr|ugs, eve|
|000057a0| 6e 20 74 68 6f 73 65 20 | 69 6e 20 74 68 65 20 73 |n those |in the s|
|000057b0| 61 6d 65 0d 0a 63 6c 61 | 73 73 2e 0d 0a 20 20 20 |ame..cla|ss... |
|000057c0| 20 20 4d 6f 73 74 20 6f | 66 20 74 68 65 20 61 67 | Most o|f the ag|
|000057d0| 67 72 61 76 61 74 69 6f | 6e 73 20 77 65 72 65 20 |gravatio|ns were |
|000057e0| 64 65 74 65 63 74 65 64 | 20 64 75 72 69 6e 67 20 |detected| during |
|000057f0| 65 78 65 72 63 69 73 65 | 20 74 65 73 74 69 6e 67 |exercise| testing|
|00005800| 3b 0d 0a 74 68 65 72 65 | 66 6f 72 65 2c 20 65 78 |;..there|fore, ex|
|00005810| 65 72 63 69 73 65 20 74 | 65 73 74 69 6e 67 20 69 |ercise t|esting i|
|00005820| 73 20 69 6d 70 6f 72 74 | 61 6e 74 20 66 6f 72 20 |s import|ant for |
|00005830| 65 78 70 6f 73 75 72 65 | 20 6f 66 20 70 6f 74 65 |exposure| of pote|
|00005840| 6e 74 69 61 6c 0d 0a 63 | 6f 6d 70 6c 69 63 61 74 |ntial..c|omplicat|
|00005850| 69 6f 6e 73 20 6f 66 20 | 64 72 75 67 20 74 68 65 |ions of |drug the|
|00005860| 72 61 70 79 20 64 75 72 | 69 6e 67 20 70 68 79 73 |rapy dur|ing phys|
|00005870| 69 63 61 6c 20 61 63 74 | 69 76 69 74 79 2e 20 20 |ical act|ivity. |
|00005880| 41 6e 74 69 61 72 72 68 | 79 74 68 6d 69 61 20 64 |Antiarrh|ythmia d|
|00005890| 72 75 67 73 0d 0a 6d 75 | 73 74 20 62 65 20 75 73 |rugs..mu|st be us|
|000058a0| 65 64 20 63 61 75 74 69 | 6f 75 73 6c 79 2c 20 62 |ed cauti|ously, b|
|000058b0| 65 63 61 75 73 65 20 6f | 66 20 74 68 65 20 66 72 |ecause o|f the fr|
|000058c0| 65 71 75 65 6e 63 79 2c | 20 75 6e 70 72 65 64 69 |equency,| unpredi|
|000058d0| 63 74 61 62 69 6c 69 74 | 79 2c 20 61 6e 64 0d 0a |ctabilit|y, and..|
|000058e0| 73 65 72 69 6f 75 73 6e | 65 73 73 20 6f 66 20 74 |seriousn|ess of t|
|000058f0| 68 65 20 73 69 64 65 20 | 65 66 66 65 63 74 20 6f |he side |effect o|
|00005900| 66 20 61 67 67 72 61 76 | 61 74 69 6f 6e 20 6f 66 |f aggrav|ation of|
|00005910| 20 61 72 72 68 79 74 68 | 6d 69 61 2e 20 20 41 20 | arrhyth|mia. A |
|00005920| 63 6f 6d 70 6c 65 74 65 | 0d 0a 65 76 61 6c 75 61 |complete|..evalua|
|00005930| 74 69 6f 6e 20 6f 66 20 | 65 61 63 68 20 70 61 74 |tion of |each pat|
|00005940| 69 65 6e 74 2c 20 69 6e | 63 6c 75 64 69 6e 67 20 |ient, in|cluding |
|00005950| 65 78 65 72 63 69 73 65 | 20 74 65 73 74 69 6e 67 |exercise| testing|
|00005960| 2c 20 69 73 20 6e 65 63 | 65 73 73 61 72 79 2e 0d |, is nec|essary..|
|00005970| 0a 0d 0a 50 6f 73 74 2d | 43 6f 6d 6d 65 6e 74 0d |...Post-|Comment.|
|00005980| 0a 0d 0a 20 20 20 20 20 | 54 68 65 20 77 6f 72 6c |... |The worl|
|00005990| 64 20 6e 65 65 64 73 20 | 61 6e 74 69 61 72 72 68 |d needs |antiarrh|
|000059a0| 79 74 68 6d 69 63 20 64 | 72 75 67 73 20 74 68 61 |ythmic d|rugs tha|
|000059b0| 74 20 61 72 65 20 6e 6f | 74 20 70 72 6f 61 72 72 |t are no|t proarr|
|000059c0| 68 79 74 68 6d 6f 67 65 | 6e 69 63 2e 2d 2d 4c 2e |hythmoge|nic.--L.|
|000059d0| 0d 0a 4c 61 73 61 67 6e | 61 2c 20 4d 2e 44 2e 0d |..Lasagn|a, M.D..|
|000059e0| 0a 24 55 6e 69 71 75 65 | 5f 49 44 7b 59 52 42 30 |.$Unique|_ID{YRB0|
|000059f0| 30 39 30 37 7d 0d 0a 24 | 54 69 74 6c 65 7b 52 65 |0907}..$|Title{Re|
|00005a00| 76 65 72 73 61 6c 20 6f | 66 20 50 72 6f 61 72 72 |versal o|f Proarr|
|00005a10| 68 79 74 68 6d 69 63 20 | 45 66 66 65 63 74 73 20 |hythmic |Effects |
|00005a20| 6f 66 20 46 6c 65 63 61 | 69 6e 69 64 65 20 41 63 |of Fleca|inide Ac|
|00005a30| 65 74 61 74 65 20 61 6e | 64 20 45 6e 63 61 69 6e |etate an|d Encain|
|00005a40| 69 64 65 0d 0a 48 79 64 | 72 6f 63 68 6c 6f 72 69 |ide..Hyd|rochlori|
|00005a50| 64 65 20 62 79 20 50 72 | 6f 70 72 61 6e 6f 6c 6f |de by Pr|opranolo|
|00005a60| 6c 7d 0d 0a 24 41 75 74 | 68 6f 72 7b 0d 0a 4d 79 |l}..$Aut|hor{..My|
|00005a70| 65 72 62 75 72 67 2c 20 | 52 4a 0d 0a 4b 65 73 73 |erburg, |RJ..Kess|
|00005a80| 6c 65 72 2c 20 4b 4d 0d | 0a 43 6f 78 2c 20 4d 4d |ler, KM.|.Cox, MM|
|00005a90| 0d 0a 48 75 69 6b 75 72 | 69 2c 20 48 0d 0a 54 65 |..Huikur|i, H..Te|
|00005aa0| 72 72 61 63 61 6c 6c 2c | 20 45 0d 0a 49 6e 74 65 |rracall,| E..Inte|
|00005ab0| 72 69 61 6e 2c 20 41 20 | 4a 72 2e 0d 0a 46 65 72 |rian, A |Jr...Fer|
|00005ac0| 6e 61 6e 64 65 7a 2c 20 | 50 0d 0a 43 61 73 74 65 |nandez, |P..Caste|
|00005ad0| 6c 6c 61 6e 6f 73 2c 20 | 41 7d 0d 0a 24 41 66 66 |llanos, |A}..$Aff|
|00005ae0| 69 6c 69 61 74 69 6f 6e | 7b 55 6e 69 76 20 6f 66 |iliation|{Univ of|
|00005af0| 20 4d 69 61 6d 69 7d 0d | 0a 24 4a 6f 75 72 6e 61 | Miami}.|.$Journa|
|00005b00| 6c 7b 43 69 72 63 75 6c | 61 74 69 6f 6e 7d 0d 0a |l{Circul|ation}..|
|00005b10| 24 56 6f 6c 75 6d 65 7b | 38 30 7d 0d 0a 24 50 61 |$Volume{|80}..$Pa|
|00005b20| 67 65 7b 31 35 37 31 2d | 31 35 37 39 7d 0d 0a 24 |ge{1571-|1579}..$|
|00005b30| 44 61 74 65 7b 31 39 38 | 39 7d 0d 0a 24 59 42 56 |Date{198|9}..$YBV|
|00005b40| 6f 6c 7b 31 39 39 31 20 | 59 65 61 72 20 42 6f 6f |ol{1991 |Year Boo|
|00005b50| 6b 20 6f 66 20 44 72 75 | 67 20 54 68 65 72 61 70 |k of Dru|g Therap|
|00005b60| 79 7d 0d 0a 24 43 68 61 | 70 74 65 72 7b 36 2d 34 |y}..$Cha|pter{6-4|
|00005b70| 34 7d 0d 0a 24 59 42 45 | 64 69 74 6f 72 7b 44 72 |4}..$YBE|ditor{Dr|
|00005b80| 73 2e 20 4c 61 73 61 67 | 6e 61 20 61 6e 64 20 57 |s. Lasag|na and W|
|00005b90| 65 69 6e 74 72 61 75 62 | 7d 0d 0a 24 54 61 62 6c |eintraub|}..$Tabl|
|00005ba0| 65 7b 7d 0d 0a 24 43 6f | 6d 6d 65 6e 74 61 74 6f |e{}..$Co|mmentato|
|00005bb0| 72 7b 4d 2e 20 57 65 69 | 6e 74 72 61 75 62 2c 20 |r{M. Wei|ntraub, |
|00005bc0| 4d 2e 44 2e 7d 0d 0a 0d | 0a 43 6f 70 79 72 69 67 |M.D.}...|.Copyrig|
|00005bd0| 68 74 20 28 43 29 20 59 | 65 61 72 20 42 6f 6f 6b |ht (C) Y|ear Book|
|00005be0| 20 4d 65 64 69 63 61 6c | 20 50 75 62 6c 69 73 68 | Medical| Publish|
|00005bf0| 65 72 73 2c 20 49 6e 63 | 2e 20 31 39 39 31 0d 0a |ers, Inc|. 1991..|
|00005c00| 0d 0a 31 39 39 31 20 59 | 65 61 72 20 42 6f 6f 6b |..1991 Y|ear Book|
|00005c10| 20 6f 66 20 44 72 75 67 | 20 54 68 65 72 61 70 79 | of Drug| Therapy|
|00005c20| 0d 0a 0d 0a 43 68 61 70 | 74 65 72 20 36 20 2d 2d |....Chap|ter 6 --|
|00005c30| 20 43 61 72 64 69 6f 76 | 61 73 63 75 6c 61 72 20 | Cardiov|ascular |
|00005c40| 44 69 73 65 61 73 65 73 | 0d 0a 0d 0a 2d 2d 2d 2d |Diseases|....----|
|00005c50| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005c60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005c70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005c80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005c90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 52 65 76 65 |--------|--..Reve|
|00005ca0| 72 73 61 6c 20 6f 66 20 | 50 72 6f 61 72 72 68 79 |rsal of |Proarrhy|
|00005cb0| 74 68 6d 69 63 20 45 66 | 66 65 63 74 73 20 6f 66 |thmic Ef|fects of|
|00005cc0| 20 46 6c 65 63 61 69 6e | 69 64 65 20 41 63 65 74 | Flecain|ide Acet|
|00005cd0| 61 74 65 20 61 6e 64 20 | 45 6e 63 61 69 6e 69 64 |ate and |Encainid|
|00005ce0| 65 0d 0a 48 79 64 72 6f | 63 68 6c 6f 72 69 64 65 |e..Hydro|chloride|
|00005cf0| 20 62 79 20 50 72 6f 70 | 72 61 6e 6f 6c 6f 6c 0d | by Prop|ranolol.|
|00005d00| 0a 0d 0a 4d 79 65 72 62 | 75 72 67 20 52 4a 2c 20 |...Myerb|urg RJ, |
|00005d10| 4b 65 73 73 6c 65 72 20 | 4b 4d 2c 20 43 6f 78 20 |Kessler |KM, Cox |
|00005d20| 4d 4d 2c 20 48 75 69 6b | 75 72 69 20 48 2c 20 54 |MM, Huik|uri H, T|
|00005d30| 65 72 72 61 63 61 6c 6c | 20 45 2c 20 49 6e 74 65 |erracall| E, Inte|
|00005d40| 72 69 61 6e 20 41 20 4a | 72 2e 2c 0d 0a 46 65 72 |rian A J|r.,..Fer|
|00005d50| 6e 61 6e 64 65 7a 20 50 | 2c 20 43 61 73 74 65 6c |nandez P|, Castel|
|00005d60| 6c 61 6e 6f 73 20 41 0d | 0a 28 55 6e 69 76 20 6f |lanos A.|.(Univ o|
|00005d70| 66 20 4d 69 61 6d 69 29 | 0d 0a 43 69 72 63 75 6c |f Miami)|..Circul|
|00005d80| 61 74 69 6f 6e 20 38 30 | 3a 31 35 37 31 2d 31 35 |ation 80|:1571-15|
|00005d90| 37 39 2c 20 31 39 38 39 | 0d 0a 2d 2d 2d 2d 2d 2d |79, 1989|..------|
|00005da0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005db0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005dc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005dd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00005de0| 2d 2d 2d 2d 2d 2d 2d 2d | 0d 0a 0d 0a 41 62 73 74 |--------|....Abst|
|00005df0| 72 61 63 74 0d 0a 0d 0a | 20 20 20 20 20 54 68 65 |ract....| The|
|00005e00| 20 75 73 65 66 75 6c 6e | 65 73 73 20 6f 66 20 61 | usefuln|ess of a|
|00005e10| 6e 74 69 61 72 72 68 79 | 74 68 6d 69 63 20 64 72 |ntiarrhy|thmic dr|
|00005e20| 75 67 73 20 69 73 20 6c | 69 6d 69 74 65 64 20 62 |ugs is l|imited b|
|00005e30| 79 20 74 68 65 20 72 69 | 73 6b 20 6f 66 20 69 6e |y the ri|sk of in|
|00005e40| 64 75 63 69 6e 67 0d 0a | 6f 72 20 61 67 67 72 61 |ducing..|or aggra|
|00005e50| 76 61 74 69 6e 67 20 61 | 72 72 68 79 74 68 6d 69 |vating a|rrhythmi|
|00005e60| 61 73 2e 20 20 49 6e 20 | 33 20 70 61 74 69 65 6e |as. In |3 patien|
|00005e70| 74 73 20 72 65 63 65 69 | 76 69 6e 67 20 66 6c 65 |ts recei|ving fle|
|00005e80| 63 61 69 6e 69 64 65 20 | 61 6e 64 20 31 0d 0a 72 |cainide |and 1..r|
|00005e90| 65 63 65 69 76 69 6e 67 | 20 65 6e 63 61 69 6e 69 |eceiving| encaini|
|00005ea0| 64 65 20 61 66 74 65 72 | 20 72 65 63 65 69 76 69 |de after| receivi|
|00005eb0| 6e 67 20 66 6c 65 63 61 | 69 6e 69 64 65 2c 20 70 |ng fleca|inide, p|
|00005ec0| 72 6f 70 72 61 6e 6f 6c | 6f 6c 20 77 61 73 20 61 |ropranol|ol was a|
|00005ed0| 64 6d 69 6e 69 73 74 65 | 72 65 64 0d 0a 74 6f 20 |dministe|red..to |
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