PROFILE OF THE 1996 KYOTO PRIZE LAUREATE
IN
BASIC SCIENCES
Fields Selected: Life Sciences (Molecular Biology,
Cell Biology, Neurobiology)
NAME : Dr. Mario Renato Capecchi
DATE OF BIRTH : October 6, 1937 age 59 (as of June 28, 1996)
NATIONALITY : U.S.A.
BRIEF BIOGRAPHY:
1937 Born in Verona, Italy
1961 B.S. Antioch College, U.S.A.
1967 Ph.D. Harvard University
1968 Assistant Professor, Harvard Medical School
1973 Professor of Biology, University of Utah
1988-present Investigator of the Howard Hughes Medical
Institute
1989-present Professor of Human Genetics, School of
Medicine, University of Utah
AWARDS AND HONORS:
1969 American Chemical Society Awards in
Biochemistry
1974 American Cancer Society Faculty Research Award
1986 Chairman of the Gordon Conference on Molecular
Genetics
1991 Member of the National Academy of Sciences,
U.S.A.
1993 Gairdner Foundation International Award for
Achievements in Medical Sciences, Canada
1994 Sloan Prize, General Motors Cancer Research
Foundation, U.S.A.
MAJOR WORKS :
1980 High efficiency transformation by direct
microinjection of DNA into cultured mammalian
cells. Cell, 22
1987 Site-directed mutagenesis by gene targeting in
mouse embryo-derived stem cells.
(with K. R. Thomas) Cell, 51
1988 Disruption of the proto-oncogene int-2 in mouse
embryo-derived stem cells: a general strategy
for targeting mutations to non-selectable
genes. (with S. L. Mansour and K. R. Thomas)
Nature, 336
1991 Regionally restricted developmental defects
resulting from targeted disruption of the mouse
homeobox gene hox-1.5
(with O. Chisaka) Nature, 350
1995 Absence of radius and ulna mice lacking hoxa-11
and hoxd-11. (with A. P. Davis, others) Nature,
375