Yes. To get Linux to detect and set up the serial devices automatically on startup, add the line:
/etc/setserial /dev/cua* auto_irq skip_test autoconfig
to your /etc/rc.local
or /etc/rc.serial
file. Do
this for every serial port you want to auto configure. Be sure to
give the correct location of where your setserial
program lives,
and give a device name that really does exist on your machine.