Day 038 - 19 Oct 94 - Page 48


     
     1   Q.   Just very briefly if we can look at paper No. 9 which is
     2        your paper No. 9.  I do not know if you have your papers?
     3        A.  I brought none of the references; my understanding was
     4        that they are supposed to be here.
     5
     6   MS. STEEL:   If you look for a bundle with a pale green label,
     7        it should have your name on it; it may be down the bottom.
     8        A.  Which number?
     9
    10   MS. STEEL:   No. 9.
    11        A.  Yes, this indeed is the paper in question, Annals of
    12        Internal Medicine.  Yes.  Here is one example where a
    13        double-blind challenge study was conducted.  Here the
    14        adverse effects were experienced by an adult -- in this
    15        case a physician.
    16
    17   MR. MORRIS:  It says in the introduction:  "We describe the case
    18        of a physician with an allergic gastroenteritis who had
    19        severe abdominal cramps requiring several
    20        hospitalisations"?
    21        A.  Yes.
    22
    23   Q.   So it is quite a severe reaction?
    24        A.  That is certainly how it is described here, yes,
    25        indeed.
    26
    27   Q.   They say:  "The cause", in the initial paragraph, "FD&C
    28        yellow No.6 dye (Sunset Yellow, City Chemical Corporation,
    29        New York, New York)"?
    30        A.  It was a product of theirs which was used to provide
    31        the challenge.
    32
    33   Q.   "Was confirmed by double-blinded challenge"?
    34        A.  Yes, indeed.
    35
    36   Q.   I think that is enough for the moment.  Was there anything
    37        else important in that particular study because we do not
    38        want to spend a long time on studies?
    39        A.  Not that I can immediately see.
    40
    41   Q.   OK.  Maybe we will move on from Sunset Yellow.
    42
    43   MR. JUSTICE BELL:  Does that give me any information apart from
    44        in relation to that one patient?
    45        A.  Not that I can see, no.  One double-blind challenge on
    46        one patient.
    47
    48   MR. MORRIS:  But is there other evidence?
    49        A.  No, in respect of gastroenteritis, but the paper
    50        I refer to in the footnote 1 by Michaelson in The Archives 
    51        of dermatology -- I believe I did provide a copy of that 
    52        document. 
    53
    54   Q.   We might as well look at No. 1, page 3.
    55
    56   MR. JUSTICE BELL:  Does anyone have any key as to what the
    57        references are in the bundles?
    58
    59   MS. STEEL:   No.  They should be in the order they are in the
    60        footnotes.

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