Day 039 - 20 Oct 94 - Page 49


     
     1
     2   MR. JUSTICE BELL:  Which page again?
     3
     4   THE WITNESS:  The first page of that paper, page 137.
     5
     6   MR. MORRIS:  The last sentence of the summary seems to be the
     7        main conclusion.
     8
     9   MR. JUSTICE BELL:  What is the ADI?  .5 milligrams or has it
    10        gone down since then?  JECFA in 1989 set an ADI of 0.5
    11        milligrams of kilogram body weight and deleted the
    12        temporary qualification, you say.  What do we have here in
    13        this one?
    14        A.  100 milligrams per kilogram was the dose given by
    15        stomach tube in the mice, but it is relatively brief -- the
    16        duration of this test is rather brief -- in that the
    17        acceptable daily intake is usually calculated over the
    18        entire lifetime of the animal, but, if I have understood
    19        this correctly, this was a relatively short-term study.
    20
    21   MR. MORRIS:  Less than 10 days or something.
    22
    23   MR. JUSTICE BELL:  What are you looking for now?
    24        A.  I am just trying to establish the length of duration of
    25        the study in which these tumours arose.
    26
    27   Q.   If we look at the bottom of page 137 and the top of page
    28        138, we have it, have we not?  There is the initial showing
    29        and then on days two to four?
    30        A.  Proliferation of cells.  So, while the dose is
    31        relatively high by comparison with the ADI, it is a very
    32        short duration exposure.
    33
    34   Q.   You say "relatively high", they describe it as large doses,
    35        do they not?
    36        A.  Yes, over short times.
    37
    38   Q.   The one follows the other; since the lesions appear very
    39        quickly ---
    40        A.  Indeed.
    41
    42   Q.   -- it is over a short period of time?
    43        A.  Indeed, yes.
    44
    45   Q.   Then it says:  "All these lung lesions are apparently fully
    46        reversible".  Does it show how long they went on for?
    47        A.  It is quite a long time since I read this paper in
    48        great detail and I cannot instantly put my finger on the
    49        duration.
    50 
    51   Q.   There has to be a limit to how much time we can spend in 
    52        court with the witness actually reading the papers to try 
    53        and find what the answer is.
    54
    55   MR. MORRIS:  Yes.  I was referring to the summary mainly for
    56        guidance there.  The one behind that, did you want to refer
    57        to that one?  I do not think you did; Peraino?
    58        A.  Peraino, that simply provides some evidence that BHT
    59        may be a tumour promoter.
    60

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