Day 010 - 11 Jul 94 - Page 74


     
     1        deposited in the adipose tissue of human beings does them
              any harm at all?
     2        A.  I am aware there is scientific research that indicates
              there is a wide range of potential effects from small
     3        amounts of this chemical in the human body.
 
     4   Q.   A certain of amount work has been done with small animals,
              rodents mostly, has it not?
     5        A.  Yes.
 
     6   Q.   You know, do you not, how cautious one must be about the
              results obtained from animal experimentation?
     7        A.  I am aware of that.
 
     8   Q.   You know, I expect, that the key to many, if not all,
              toxicological problems is the level of dosage, amount?
     9        A.  Repeat the question?
 
    10   Q.   One of the underlying principles of toxicology, the
              science for telling us what is going to damage us in the
    11        environment, is dosage?
              A.  Dosage is one of the issues, yes.
    12
         Q.   It is one of the fundamental principles of toxicology?
    13        A.  Actually, I think these areas of studies are generally
              referred to as epidemiology.
    14
         Q.   We are not talking about epidemiology. We are talking
    15        about experimental work, clinical work.  It is from
              experimental work that we know that even water in large
    16        doses may be toxic, do we not?
              A.  I think that -----
    17
         MR. JUSTICE BELL:  Can I put it another way.  If you sit in a
    18        motor car in a traffic jam Benzyne builds up in the cabin
              of the car?
    19        A.  Yes.
 
    20   Q.   You say Benzyne is a carcinogen.  That does not mean you
              can sit in traffic jam you are going to get cancer.  You
    21        have to look at dosage as one of the important factors, do
              you not, in deciding whether any substance is toxic?
    22        A.  Well, I agree that you have to look at dosage, yes,
              but I also would add that you need to understand the
    23        impact, or you need to look at the significance of the
              presence of these substances in the body fat; that in the
    24        body tissue, in the body cells these reactions may have
              very little relationship to specifically the initial
    25        dosage or any series of dosages.
  
    26   MR. RAMPTON:  My Lord, I am going to depart now from styrene 
              migration and turn to two other topics.  I do not believe 
    27        I can finish them by quarter past 4.  I have to call
              Professor Duxbury tomorrow morning, as your Lordship
    28        knows.  Would your Lordship like me to finish now, there
              may be some re-examination, I do not know, or would your
    29        Lordship like it if Mr. Lipsett can stay overnight so that
              I finish it tomorrow sometime?
    30
         MR. JUSTICE BELL:  I think you said Mr. Lipsett could be here

Prev Next Index