Day 039 - 20 Oct 94 - Page 48


     
     1        Perhaps Helen can have a look for that.  Maybe we can move
     2        on to Nos. 91 and 92.
     3        A.  We are on BHT now.
     4
     5   Q.   Yes.  The conclusion of summary in 91 is:  "It is concluded
     6        that BHT, given by stomach tube and in doses higher than
     7        100 milligrammes per kilogramme produces extensive cell
     8        proliferation in mouse lung and acts as a promoting agent
     9        in adenoma development"?
    10        A.  Yes.
    11
    12   Q.   Is that the main -----
    13        A.  I think it is, yes, indeed.
    14
    15   MR. JUSTICE BELL:  Where are you for that?
    16
    17   MR. MORRIS:  That is the last sentence of the tab, the summary
    18        of tab 91.
    19
    20   MR. JUSTICE BELL:  Yes.  Page?
    21
    22   MR. MORRIS:  Page 137.  It is tab 91.
    23
    24   MR. JUSTICE BELL:  My pages on that are 93, 94 and 95.
    25
    26   MR. MORRIS:  There are two parts to tab 91.  It is:  "Toxicity
    27        of Buytylated Hydroxytoluene in mouse following oral
    28        examination" (sic)?
    29        A.  "... following oral administration" it is.
    30
    31   Q.   Yes.  Toxicology No. 9.
    32
    33   MR. JUSTICE BELL:  I have in 91:  Enhancing effects of
    34        Phenobarbitone and BHA.
    35
    36   MS. STEEL:  Is that the only one?
    37
    38   MR. JUSTICE BELL:  It runs from pages 93 to 95.  Then I have:
    39        On the aetiology of gastric cancer; mutagenicity of food
    40        extracts after incubation with nitrite?
    41        A.  Earlier in the set at tab 91, do you not also have
    42        Witschi and Lock?
    43
    44   MR. JUSTICE BELL:  I see, I have under (A):  Modification of
    45        Gastrointestinal -- it that one -- Tumour Development in
    46        Rats?
    47
    48   MS. STEEL:  That should be 92.
    49
    50   MR. JUSTICE BELL:  Yes, that is right.  What are you looking 
    51        at? 
    52 
    53   THE WITNESS:  I am looking at a paper at the front of 91 by
    54        Hanspeter Witschi and Simon Lock, published in the journal
    55        Toxicology in 1978 entitled:  "Toxicity of Butylated
    56        Hydroxytoluene in mouse following oral administration".
    57
    58   MR. JUSTICE BELL:  I do not have that.
    59
    60   MR. MORRIS:  Robert has a spare copy.  (Handed).

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