Day 269 - 25 Jun 96 - Page 73
1 blood, and that is going on all the time, thankfully.
2
3 Q. It is a specific creature?
4 A. Specialised is a better word for it.
5
6 Q. Specialised?
7 A. And I believe you have very similar parameters in
8 these sort of adhesive properties of cancer cells.
9
10 Q. Now, if your theories were right?
11 A. Yes.
12
13 Q. You could expect the activity of the metastasis and the
14 appearance of secondary tumours to mirror the appearance,
15 not depend upon, but to mirror the appearance of
16 atheromas. In other words, they would appear in the same
17 sites of the body?
18 A. No, not necessarily. With respect, I disagree with
19 that. The reason for this is that I think we are looking
20 at two different types of genetic susceptibility. I think
21 that the more we understand about genetics the more we have
22 a clear understanding that one person may be susceptible to
23 coronary heart disease and thrombosis and another person
24 might be more susceptible to cancer of one kind or another,
25 and I think that you would not necessarily predict that you
26 would get the same kind of pattern or distribution of
27 adhesion in the cancer cell compared to the platelet. They
28 are different phenomenon, as you have rightly said.
29
30 Q. Well, they are different phenomenon are they not?
31 A. Yes.
32
33 Q. And it is not that the platelet are assisting the
34 implantation, if I can call it that, of the drifting or
35 migrant cancers?
36 A. No, not at all. I mean, whether they do or not I have
37 no evidence one way or the other, but it is not part of the
38 thesis that I--
39
40 Q. No?
41 A. -- postulated.
42
43 Q. And it really goes this far, that there is an
44 epidemiological, if you like, association between high
45 peridural cholesterol levels and certain kinds of cancer?
46 A. Yes, there is, but there are a number of studies which
47 have actually suggested that people who have cancer that
48 lower blood cholesterols and this raised, at one stage, a
49 significant scare of those of the other side of the
50 population that were trying to get people to reduce their
51 blood cholesterol levels. There was an idea at one stage
52 that made people think that a low blood cholesterol was
53 actually a risk factor for cancer and this appeared again
54 with the Pearson Dayton study clearly early on where one of
55 the very first major studies in the United States of
56 America where they intervene with reducing a high saturated
57 fat diet and increasing the polyunsaturated content of the
58 diet where they actually found more cancer cases in the
59 group that had the reduced mortally from heart disease.
60
