Day 039 - 20 Oct 94 - Page 35


     
     1        substances?
     2        A.  I think I have commented on that, that I know of no
     3        study published in the scientific literature providing
     4        direct evidence of that.  However, the Hyperactive Children
     5        Support Group have numerous reports that BHA and BHT
     6        trigger hyperactivity.
     7
     8        As I said before, unlike the nitrates, it is relatively
     9        straightforward to obtain products; the only difference of
    10        which is the presence or absence of those antioxidants.
    11
    12   Q.   I realise I have asked that question before, but on the
    13        other symptoms of intolerance on our list from the original
    14        pleadings, which is in many ways superseded now, for BHA,
    15        which Professor Walker said was based on some evidence, we
    16        put:  "Can cause raised lipid and cholesterol levels in the
    17        blood".
    18        A.  Now, that is -- there I would draw your attention to
    19        the paper by Fisherman and others in Annals of Allergy in
    20        1977.
    21
    22   Q.   The number?
    23        A.  Well, it is 54 and then it, presumably, has got a
    24        subscript assigned to it.  54(d).
    25
    26   Q.   Is it the Serum Triglyceride?
    27        A.  And Cholesterol Levels, yes.
    28
    29   Q.   That is the third one.
    30        A.  I believe it is, yes.
    31
    32   Q.   Do you want to point to the relevant conclusion?
    33        A.  Well, the abstract which is printed above the title of
    34        the paper, albeit written in rather opaque medical prose,
    35        indicates that they are providing evidence from, I believe
    36        it is, a sample of 85 patients amongst whom they found
    37        direct evidence that BHA and BHT raised a level of
    38        triglyceride circulating in the blood, certainly suggests
    39        that these compounds are not pharmacologically inert in
    40        raising, yes, raising .....
    41
    42   Q.   This applies to BHA and BHT, does it?
    43        A.  That is my reading of this paper, yes, indeed.
    44
    45   Q.   And, having read that, what are the symptoms or effects of
    46        such a reaction, or is that just a contributing effect to
    47        other problems with high cholesterol levels?
    48        A.  I think it is.  I think that is precisely right.  Yes,
    49        in fact, I wrongly characterised it a few -----
    50 
    51   MR. JUSTICE BELL:  If we look, IAD is intrinsic allergic 
    52        hypersensitivity diseases. 
    53        A.  Yes.
    54
    55   Q.   On the last page, just above the references:  "The
    56        significance of this information suggests the importance of
    57        the deranged metabolism as a factor in the genesis of IAD
    58        associated with chemical hypersensitivity (intolerance)
    59        states and may lead to newer or different modalities of
    60        understanding and therapy in these syndromes".  Is that the

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