Anti-plasmin: Transamin
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The very first anti-plasmin drug was developed in Japan by Mitsubishi Chemical Industries in 1947. In 1954, The Daiichi Seiyaku Company - in coopera-tion with Hayashi Takashi of Keio University, Tokyo-marketed the anti-plasmin drug Ipsilon ( Ipsilon-amino caglon acid). AMCHA (4-amino methyl cyclohexane carbonic acid), another anti-plasmin drug, was developed by Okamoto Akisuke of Kobe University in 1961. Four years later, the effective ingredient of AMCHA was marketed in trans-isomer form by Daiichi Seiyaku under the name Transamin.
The molecular weight of Transamin is 157; it melts and decomposes at 386-392 Celsius. Available in crystalline and powder form, it has no smell and is somewhat bitter in taste. Transamin dissolves in water (1 gram Transamin/6ml water) but it is barely soluble in organic solvents. The medical benefits of Transamin are its powerful resistance to plasmin and its effectiveness in cases of haemorrhage, allergy and inflammation.
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